Visakhapatnam

THE ROLE OF COX-2 INHIBITORS IN HUMAN CANCER PREVENTION AND OTHER NOVEL TARGETS - A RECENT REVIEW

About Authors:
Lohithasu Duppala*1, Madhu priya Damuluri1, Anil kumar vadda2
1
GITAM Institute of Pharmacy, GITAM University, Pharmaceutics, visakhapatnam, Andhra Pradesh, India-530045.
2
AVANTHI Institute of pharmaceutical sciences, pharmacology, visakhapatnam, Andhra Pradesh, India-530045.
*
lohithasu@gmail.com, anilkumar.vadda@gmail.com

ABSTRACT:
COX-2 (Cyclooxygenase-2) is a selective inhibitor of non-steroidal anti-inflammatory drug (NSAID). Cyclooxygenase -2, an enzyme responsible for inflammation and pain. Celecoxib, Rofecoxib, valdecoxib, Parecoxib are class of COX-2 inhibiting drugs. COX-2  inhibitors have been revealed to reduce the occurrence of cancers and pre-cancerous growths. Celecoxib, cox-2 inhibitor isused to prevention of polyp formation in Familial Adenomatous Polyposis (FAP). COX-2 inhibitors like celecoxib, Rofecoxib, valdecoxib, Parecoxibare currently being studied in  cancer treatment and other targets. This review highlights the COX-2 inhibitors with special emphasis on their role in various kinds of cancer prevention and other targeted therapy. COX-2 inhibitors in cancer chemotherapy and neurological diseases like Parkinson and Alzheimer’s diseases still continues to attract researches on the development of COX-2 inhibitors.

DISCUSSION ON NOVEL RECTAL DRUG DELIVERY SYSTEMS –A RECENT REVIEW

About Authors:
Anil kumar vadda1, Lohithasu Duppala2
1AVANTHI Institute of pharmaceutical sciences, pharmacology,
2GITAM Institute of Pharmacy, GITAM University, Pharmaceutics,
visakhapatnam, Andhra Pradesh, India-530045
2lohithasu@gmail.com, 1anilkumar.vadda@gmail.com

ABSTRACT:
Rectal drug delivery is an efficient alternate to oral and parenteral route of administration in partial avoidance of first pass metabolism and protein peptide drug delivery. This route allows both local and systemic therapy of drugs. Controlled absorption enhancement of drugs can be achieved by the rectal route because of the constant conditions in the rectal environment. In the present review presents various dosage forms used in rectal route, factors related recatal route of absorption ,fate of drug  absorption. This review also presents polymers in rectal route of drug delivery.

DISCUSSION ON NOVEL VAGINAL DRUG DELIVERY SYSTEMS – A RECENT REVIEW

About Authors:
Lohithasu Duppala1*, Anil kumar vadda2
1GITAM Institute of Pharmacy, GITAM University, Pharmaceutics, visakhapatnam, Andhra Pradesh, India-530045.
2AVANTHI Institute of pharmaceutical sciences, pharmacology, visakhapatnam, Andhra Pradesh, India-530045.
1lohithasu@gmail.com, 2anilkumar.vadda@gmail.com

INTRODUCTION:
Commonly, the olden days ,vaginal drug delivery systems are used to deliver vaginal infections treatment drugs  and contraceptives.1
The advantage of intra-vaginal controlled drug administration over conventional/traditional oral administration is the drug absorbed systemically because due to the presence of dense network of blood vessels in vaginal wall The vaginal cavity is also an effective site for the uterine targeting of various therapeutic agents such as terbutaline, progesterone and danazol.2   But now-a-days ,the poorly absorbed oral drugs to be formulated as targeted vaginal drug delivery system to treat vaginal infections. In 1970, the first vaginal ring was used for delivery of medroxyprogesterone acetate for contraception.3 Vaginal drug delivery systems are traditionally used to deliver contraceptive and drugs to treat vaginal infections.

Job as Manager-API Process Engineering function in Pharmatechnology and Manufacturing Ltd- alp consulting

Company based in Tokyo, Japan is a research-based human health care (hhc) company that discovers, develops and markets products throughout the world. Company corporate human health care (hhc) mission is to give first thought to patients and their families, and to increase the benefits that health care provides. Pharmatechnology and Manufacturing Pvt. Ltd, a subsidiary of Co.

Pages