Visakhapatnam

Job as Project Assistant-II in The National Institute of Oceanography

The National Institute of Oceanography (NIO) with its headquarters at Dona Paula, Goa, and regional centers at Kochi, Mumbai and Visakhapatnam, is one of the 38 constituent laboratories of the Council of Scientific & Industrial Research (CSIR), New Delhi. NIO was established on 1 January 1966 following the International Indian Ocean Expedition (IIOE) in early 1960s.

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Dr. Reddy's Laboratories (NYSE: RDY) is an emerging global pharmaceutical company with proven research capabilities. The company is vertically integrated with a presence across the pharmaceutical value chain. It produces finished dosage forms, active pharmaceutical ingredients and biotechnology products and markets them globally, with focus on India, US, Europe and Russia.

Formulation and In-vitro characterization of Gelatin Micro spheres loaded with Lisinopril dihydrate

ABOUT AUTHORS:
Sudha Talasila*1, Yamini Pendyala2, Deepthi Madhu3, Dr.K.L.Senthil kumar.
1,2 Department of Pharmaceutics,
Padmavathi College of Pharmacy and Reserch institute,
periyanahalli, Tamilnadu, India.
3 Department of Pharmaceutics, Gitams university,
Visakhapatnam, India.

ABSTRACT
Aim of our present study was to formulate the Gelatin Microspheres Loaded with Lisinopril Dihydrate by using Co-acervation phase separation technique for control prolonged release of drug. Micro-particulate drug delivery of Lisinopril Dihydrate was prepared by using a blend of gelatin-carbopol 934P NF and Gelatin-Sodium alginate as release retardant.Lisinopril Dihydrate Microspheres were formulated by using different drug, gelatin-carbopol and gelatin-sodiumalginate in 6 batches was F1, F2, F3, F4, F5 & F6. All the formulations were investigated for various evaluation parameters like particle size, Bulk density, flow behavior, Entrapment efficiency, percentage yield and in vitro drug release etc. All the formulations showed good flow behavior. SEM study revealed that the spheres were almost spherical in shape with smooth surface. In-vitro drug release study showed that by increasing the polymer concentration the drug release of all the formulations were gradually decreased and the optimized formulation (F6) was able to sustain the drug release for 24 hours. So, it was concluded that gelatin microspheres loaded with Lisinopril Dihydrate can be prepared by Coacervation phase seperation  technique and used for sustaining the drug release for prolonged period of time.

Career as Assistant Professor, Associate Professor, Professor in GITAM | Departments of Pharmacy, Biotechnology, Bioinformatics, Chemistry

Gandhi Institute of  Technology and Management,  popularly known as GITAM was founded in 1980 by an inspired group of eminent intellectuals and industrialists of Andhra Pradesh led by Dr. M.V.V.S.Murthi, Former Member  of  Parliament  and popular philanthropist.   Their mission was to set up a  world-class technology  and  management  institution  in  the  pictu

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