Visakhapatnam

THE ROLE OF NEW GENERATION PHYTO HORMONES: AN OVERVIEW

ABOUT AUTHORS:
Lohithasu Duppala*, Santhosh naidu Matsa, Manikumar Kothakota,

GITAM Institute of Pharmacy, GITAM University, visakhapatnam, Andhra Pradesh, India-530045.

lohithasu@gmail.com, +91-9491894432

ABSTRACT:
Generally, almost all communication in higher plants was thought to be mediated by the five classes of classical plant hormones  i.e. auxins, cytokinins,  gibberellins, abscisic acid and ethylene. The plant hormone action thus appeared to be basically different from that in animals. This article discusses the general role for new generation of plant hormones includes Brassinosteriods, Salicylic acid. Peptides,Polyaminesand Jasmonates.

THE ROLE OF COX-2 INHIBITORS IN HUMAN CANCER PREVENTION AND OTHER NOVEL TARGETS - A RECENT REVIEW

About Authors:
Lohithasu Duppala*1, Madhu priya Damuluri1, Anil kumar vadda2
1
GITAM Institute of Pharmacy, GITAM University, Pharmaceutics, visakhapatnam, Andhra Pradesh, India-530045.
2
AVANTHI Institute of pharmaceutical sciences, pharmacology, visakhapatnam, Andhra Pradesh, India-530045.
*
lohithasu@gmail.com, anilkumar.vadda@gmail.com

ABSTRACT:
COX-2 (Cyclooxygenase-2) is a selective inhibitor of non-steroidal anti-inflammatory drug (NSAID). Cyclooxygenase -2, an enzyme responsible for inflammation and pain. Celecoxib, Rofecoxib, valdecoxib, Parecoxib are class of COX-2 inhibiting drugs. COX-2  inhibitors have been revealed to reduce the occurrence of cancers and pre-cancerous growths. Celecoxib, cox-2 inhibitor isused to prevention of polyp formation in Familial Adenomatous Polyposis (FAP). COX-2 inhibitors like celecoxib, Rofecoxib, valdecoxib, Parecoxibare currently being studied in  cancer treatment and other targets. This review highlights the COX-2 inhibitors with special emphasis on their role in various kinds of cancer prevention and other targeted therapy. COX-2 inhibitors in cancer chemotherapy and neurological diseases like Parkinson and Alzheimer’s diseases still continues to attract researches on the development of COX-2 inhibitors.

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