Visakhapatnam

THE ROLE OF COX-2 INHIBITORS IN HUMAN CANCER PREVENTION AND OTHER NOVEL TARGETS - A RECENT REVIEW

About Authors:
Lohithasu Duppala*1, Madhu priya Damuluri1, Anil kumar vadda2
1
GITAM Institute of Pharmacy, GITAM University, Pharmaceutics, visakhapatnam, Andhra Pradesh, India-530045.
2
AVANTHI Institute of pharmaceutical sciences, pharmacology, visakhapatnam, Andhra Pradesh, India-530045.
*
lohithasu@gmail.com, anilkumar.vadda@gmail.com

ABSTRACT:
COX-2 (Cyclooxygenase-2) is a selective inhibitor of non-steroidal anti-inflammatory drug (NSAID). Cyclooxygenase -2, an enzyme responsible for inflammation and pain. Celecoxib, Rofecoxib, valdecoxib, Parecoxib are class of COX-2 inhibiting drugs. COX-2  inhibitors have been revealed to reduce the occurrence of cancers and pre-cancerous growths. Celecoxib, cox-2 inhibitor isused to prevention of polyp formation in Familial Adenomatous Polyposis (FAP). COX-2 inhibitors like celecoxib, Rofecoxib, valdecoxib, Parecoxibare currently being studied in  cancer treatment and other targets. This review highlights the COX-2 inhibitors with special emphasis on their role in various kinds of cancer prevention and other targeted therapy. COX-2 inhibitors in cancer chemotherapy and neurological diseases like Parkinson and Alzheimer’s diseases still continues to attract researches on the development of COX-2 inhibitors.

DISCUSSION ON NOVEL RECTAL DRUG DELIVERY SYSTEMS –A RECENT REVIEW

About Authors:
Anil kumar vadda1, Lohithasu Duppala2
1AVANTHI Institute of pharmaceutical sciences, pharmacology,
2GITAM Institute of Pharmacy, GITAM University, Pharmaceutics,
visakhapatnam, Andhra Pradesh, India-530045
2lohithasu@gmail.com, 1anilkumar.vadda@gmail.com

ABSTRACT:
Rectal drug delivery is an efficient alternate to oral and parenteral route of administration in partial avoidance of first pass metabolism and protein peptide drug delivery. This route allows both local and systemic therapy of drugs. Controlled absorption enhancement of drugs can be achieved by the rectal route because of the constant conditions in the rectal environment. In the present review presents various dosage forms used in rectal route, factors related recatal route of absorption ,fate of drug  absorption. This review also presents polymers in rectal route of drug delivery.

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