Ben-Gurion University researchers have developed a dynamic "smart" drug that targets inflammation in a site-specific manner and reduce side-effects. Study is reported in reported in the current issue of Journal of Immunology.
This novel anti-inflammatory molecule when injected it acts as a non-active drug and a localized site with excessive inflammation will activate it. The researchers demonstrated their findings in a mouse model of local inflammation.
"This development is important because inhibition of inflammation in a non-specific manner reduces the natural ability to fight infections and is a common side effect of anti-inflammatory biologic therapeutics," said one of the researchers Peleg Rider from Ben-Gurion University of the Negev (BGU), Israel.
"The beauty of this invention lies in the use of a known natural biological code. We mimicked a natural process that occurs during inflammation," Rider said. "Upon resolution of inflammation, the activation of the protein is also reduced and side effects are avoided," he added.
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