Pune

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Post: Pharmacovigilance fresher

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ABOUT AUTHORS:
Shete Reshma S.¹*, Gadhave Manoj V.², Gaikwad D. D.^3
1Department of Quality Assurance Techniques,
²Department of Pharmaceutics,
³Department of Pharmaceutics,
VJSM’S Vishal institute of pharmaceutical education and research, Ale, Pune, Maharashtra, 412411
*reshma.s.shete@gmail.com

ABSTRCT
Simvastatin is a poorly soluble drug exhibiting poor dissolution pattern. Simvastatin, PEG 6000 & Poloxamer 407 solid dispersions were prepared with a view to study the influence of polymer on solubility and dissolution of this poorly soluble drug Simvastatin. Solid dispersions of Simvastatin were prepared using different ratios of PEG 6000 & Poloxamer 407 as carrier by, solvent evaporation method. They were evaluated for percentage yield, drug content, FTIR spectral studies, DSC, XRD, solubility, and in-vitro dissolution. The solubility profile indicated that there is increase in solubility of Simvastatin when polymer concentration is increased. The solid dispersion complex of drug (1:5:5 ratios) was giving better dissolution profile as compared to pure drug and other solid dispersions. This in turn can improve the bioavailability. FT-IR, DSC shows the compatibility of drug and carrier.

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ABOUT AUTHORS:
Auti Snehal D.*¹, Jadhav S. L², Gadhave Manoj V^3
1Department of Quality Assurance Techniques
^2,3Department of Pharmaceutics
VJSM’S Vishal institute of pharmaceutical education and research, Ale, Pune, Maharashtra, 412411
snehal.d.auti@gmail.com

ABSTRACT:
The present research work discusses the development of a dissolution method for Fluconazole using UV spectrophotometer. Simple, accurate and cost efficient dissolution method has been developed for the estimation of Fluconazole in bulk and tablet dosage form. The optimum conditions for the dissolution of the drug were established. The dissolution media was found to be 0.1N HCl (pH 1.2). The apparatus was found to be USP II, Paddle and the speed was found to be 50 rpm for 30 minutes time interval.

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Post: Pharmacist

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Post: Scientist

Clini India is a progressive and premier academy in clinical research that has rapidly gaining a good reputation for excellence through its innovative approach in clinical research.
Clini India is an academy with a good reputation in clinical research industry. Clini India is a premier institution of CR education in clinical research domain.Clini India delivers Full time, Part time and e- learning training in Clinical research education.

Post: Corporate Interface Executive