Skip to main content

Kolkata

  • NANO-PARTICLES CONTAINING ANTICANCER DRUG

    { DOWNLOAD AS PDF }

    ABOUT AUHTORS
    Debpratim Chakraborty*, Nisha Lama Yolmo
    Department of Pharmaceutical tech,
    Jadavpur University,
    Kolkata, West Bengal, India
    *debpratim008@gmail.com

    ABSTRACT:
    Now a day in medical science and researches, cancer is one of the most life threatening disease but unfortunately still now we have no medical treatment for procurement of this disease. The pathology is not totally clear but according to medical evidence if we consider genes then we must agree that oncogene and tumor suppressor genes are mainly responsible. There are some risk factor also consider which may leads to cancer. The conventional treatments are surgery, Radio-therapy and chemo therapy but the real fact is none of the above mentioned treatment is enough for procurement of cancer and that’s why now scientist and researchers are thinking about nan-technology. NCI has identified that nano-technology have the potential to make paradigm changing impacts on the detection, treatment and prevention of cancer.  There are different strategies for cancer therapy using nano-particles like targeted and non-targeted nano-particles. Different studies show that the side effect of doxorubicine (an anticancer drug) can be minimizing by nano-technology, which also reduce the multi drug resistance. Nano-sphere and Nano-capsule of anti-steroid 4-hydroxytamoxifen RU reduce estrogen dependent tumor. Dendritic nano-technology with 5-fluro Uracil decreases the drug clearance and increase the therapeutic time. Methotrixate incorporated dendritic polymer target the folic acid receptor. Camptothecin loaded nano-particles show longer plasma retention, high and longer tumor localization. Nano-particles prepared by poly-lactic-co-glycolide increase the half life of Cisplatin. Paclitaxel, a microtubule-stabilizing agent that promotes polymerization of tubulin causing cell death by disrupting the dynamics necessary for cell division, is effective against a wide spectrum of cancers. Miscellaneous agent like Arsenic trioxide, Butyric Acid, Diethylene-triamine-Acetic acid show more prominent activity. Recent development in nanoparticle-based combination therapy have shown several unique features that are untenable in traditional chemotherapy. Drug combinations can now be optimizedand cleverly delivered in a more effective way.

  • Job for M.Pharm, M.S.Pharm at NIPER as Doctoral Fellow

    National Institute of Pharmaceutical Education & Research, Kolkata (NIPER-Kolkata) (Established in the year 2007) is a prestigious Educational Institution of National Importance under the aegis of Dept, of Pharmaceuticals, Ministry of Chemical & Fertilizers, Govt, of India, presently housed at the campus of CSIR-IICB, Jadavpur, Kolkata- 700 032.

    Applications are invited for walk-in interview in the enclosed prescribed format for the following posts on purely contract basis initially for a period of one year which may be extended or curtailed on the basis of the performance of the candidates and on mutual consent or requirement of the Institute as the case may be.

    Post : Post-Doctoral Fellow (02 posts)

  • Recruitment for B.Pharm, M.Pharm at Central Drugs Laboratory - CDSCO | 10 posts

    Central Drugs Laboratory' is the Appellate laboratory working under administrative control of Drugs Controller General (I), CDSCO, DGHS, MOH & F.W, Govt, of India, New Delhi. Applications received from the candidates are in prescribed format in respect of above post purely on contractual basis and the contractual period may be reduced or extended at the sole direction of CDSCO, HQ, New Delhi .During the contract period services can be terminated without any notice or without any reason whatsoever.

    Post: Bench Chemist

    [adsense:336x280:8701650588]

  • Applications are invited for M.Pharm/M.Tech / M.Sc / as Senior Research Fellow at Indian Institute of Technology

    The history of the IIT system dates back to 1946 when a committee was set up by Hon'ble Sir Jogendra Singh, Member of the Viceroy's Executive Council, Department of Education, Health and Agriculture to consider the setting up of Higher Technical Institutions for post war industrial development in India. The 22 member committee headed by Sri N.R.Sarkar, in its report, recommended the establishment of four Higher Technical Institutions in the Eastern, Western, Northern and Southern regions, possibly on the lines of the Massachusetts Institute of Technology, USA, with a number of secondary institutions affiliated to it. The report also urged the speedy establishment of all the four institutions with the ones in the East and the West to be started immediately. The committee also felt that such institutes would not only produce undergraduates but they should be engaged in research, producing research workers and technical teachers as well. The standard of the graduates should be at par with those from first class institutions abroad.

    Applications are invited on plain paper for the following assignment on a purely time bound Project undertaken in the various Departments / Centres / Schools of the Institute.

    Interested eligible persons may apply (quote SRIC Reference on the top of the Application) on plain paper giving full bio-data along with attested copies of testimonials and a demand draft of the application fee drawn in favour of IIT Kharagpur payable at Kharagpur on or before last date mentioned against each.

    Post : Senior Research Fellow - 01 Post

  • Career for Research Associate in Indian Institute of Chemical Biology | walk in

    The Institute was established in 1935 as the first non official centre in India for biomedical research and was included within the aegis of CSIR in 1956.  IICB today is engaged in research on diseases of national importance and biological problems of global interest, employing sophisticated state-of-the-art technology in keeping with the rapid and unprecedented momentum that life science research has gained globally over the last 50 years.

    Post : Research Associate - 01 post

  • Vacancy for Pharmacist at National Institute of Homoeopathy

    National Institute of Homoeopathy is a model Institute conducting Under Graduate and Post-Graduate courses and Research on various aspects of Homoeopathy. The Institute is having hospital comprising Out-Patients' Department and 100 bedded In-Patients Department (being expanded to 250 beds) along with Laboratory Medicine and Diagnostic sections.

    Post : Pharmacist-cum-Dispenser:

  • Walk in interview for Residue Analyst, Biochemist in Quality Control Laboratory at TBI

    Tea is one of the industries, which by an Act of Parliament comes under the control of the Union Govt. The genesis of the Tea Board India dates back to 1903 when the Indian Tea Cess Bill was passed. The Bill provided for levying a cess on tea exports - the proceeds of which were to be used for the promotion of Indian tea both within and outside India. The present Tea Board set up under section 4 of the Tea Act 1953 was constituted on 1st April 1954.

    A walk-in-interview will be held on 9th January, 2017 as per following from 11.00 a.m. onward at Tea Board India, 14, BTM Sarani, Kolkata- 700 001 for engaging Two contractual scientists as per followings to work in Quality Control Laboratory, Tea Park, Siliguri purely on temporary basis initially for a period of one year, which may be extended based on performance.

  • PharmaTutor Magazine - January 2017 is released | Subscribe today

  • PREPARATION AND IN-VITRO EVALUATION OF DICLOFENAC SODIUM TRANSDERMAL PATCHES

    { DOWNLOAD AS PDF }

    ABOUT AUHTOR
    SUSMITA DAS*
    Department of Pharmaceutical Technology, 
    Jadavpur University,
    West Bengal, India

    *sdas53662@gmail.com

    ABSTRACT:
    Objectives: The aim of the present study was to develop transdermal matrix patches with a fixed ratios of polyvinylpyrrolidone (PVP) and ethylcellulose (EC), containing the drug diclofenac sodium and to perform the physicochemical, in vitro relese pattern evaluation of the prepared patches. The prospective objective was the demonstration that the system provides the delivery of drug at a controlled rate across intact skin to achieve a therapeutically effective drug level for a longer period of time from transdermal patches.
    Methods: In this study, matrix-type transdermal patches containing diclofenac sodium were prepared using different ratio of polyvinylpyrrolidone (PVP) and ethylcellulose (EC) by solvent evaporation technique. The drug matrix film of PVP and EC was casted on a polyvinylalcohol backing membrane. All the prepared formulations were subjected to physical studies (moisture content, moisture uptake, and flatness), and in-vitro release kinetics and permeation studies were performed across cadaver skin using a modified diffusion cell.
    Results and conclusion: Variations in drug release profiles among the formulations studied were observed. From the formulated patches FA 1, containing PVP/EC in ratio of 1:3 shows sustained release action with 38% release after 24 h and 10 µg of drug permeation accross 1 cm2 of patch area. Hence, it can be reasonably concluded that diclofenac sodium can be formulated into the transdermal matrix type patches to sustain its release characteristics for manufacturing transdermal patches of diclofenac sodium

  • Vacancy for Research Chemist at TCG Lifesciences

    TCG Lifesciences Private Limited (formerly "Chembiotek Research International") is a leading contract research services company in the area of early drug discovery and development. We started our operations in the year 2001 in India; currently we have our presence in United States, Europe, Japan and Australia. We have a strong talent pool of 800+ trained scientists, drawn from the best national and international institutes and industry. Our services span from specific solutions to integrated discovery projects across multiple therapeutic areas with focus on Central Nervous System (CNS), Inflammation & Pain, Metabolic Disorders and Infectious Diseases.

    Post : Research Chemist/Senior Research Chemist

Subscribe to Kolkata