Chennai

Anna University Chennai Regional Office  Tiruchirappalli (Formerly Anna University Tiruchirappalli) has been established as a Annal University Chennai Regional Office Tiruchirappalli by the Government of Tamilnadu. The Regional Office is functioning from 01-08-2012 at Tiruchirappalli, which is famously known as Rock Fort city. The Regional Office is situated 17Kms away in the main highway of Tiruchirappalli to Pudukkottai.

About Authors:
S.Dinesh*, M.Senthil Kumar, Ashok kumar, Hariharan, jenish, Marshal joseph
Annai veilankanni’s pharmacy college
saidapet, chennai – 600 015.
Tamil nadu, pin:600015
*dinesh.pharmacy@gmail.com

ABSTRACT
Cinitapride1-2, chemically4-amino-N[3-(Cyclohexan-1-yl-methyl)-4-piperidinyl]-2-ethoxy-5-nitrobenzamide has the molecular formula C₂₁H₃₀N₄O₄ and molecular weight 402.49 g.Cinitapride is a drug that has against action to the serotoninergic 5-HT₂ and D₂ dopaminergic receptors that has been indicated in the gastro esophageal reflux and in the functional disorders of gastrointestinal motility treatment, The present study was aimed to formulate and evaluvate the tablets containing Cinitapride based on floating  technique in order to increase gastric retention time, Total 9 formulation (F1-F9)were done using 3 different polymers like (HPMC k4m, HPMC e15m and HPMC k100m ). The formulations prepared were subjected to dissolution tests for 12 hrs, Among all the 9 formulation  formulation (F5) were able to efficiently control Cinitapride release over a time period of 12 hrs. Thus the results of the current study clearly indicate, a promising potential of the floating tablet as an alternative to conventional dosage form.

About Authors:
Jenish.R*, M.Senthil kumar, Dinesh, Ahokkumar, Marshel, Hariharan
Annai veilankanni’s college of pharmacy
Saidapet, Chennai-600015
Tamilnadu
*jenishnathan@gmail.com

ABSTRACT
Alfuzosin is a non-subtype specific alpha(1)-adrenergic blocking agent that exhibits selectivity for alpha(1)-adrenergic receptors in the lower urinary tract. Inhibition of these adrenoreceptors leads to the relaxation of smooth muscle in the bladder neck and prostate, resulting in the improvement in urine flow and a reduction in symptoms in benign prostate hyperplasia. Alfuzosin also inhibits the vasoconstrictor effect of circulating and locally released catecholamines (epinephrine and norepinephrine), resulting in peripheral vasodilation. The alfuzosin of the present investigation is designed to retain in the stomach and deliver the drug alfuzosin for longer periods of time. The developed floating provides increased absorption of the alfuzosin at a rate such that effective plasma levels can be achieved and maintained for a prolonged duration. Formulations 6 displayed drug release considered in 0.1N HCL and Formulation 6 shows better drug release in dissolution profile.

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