About Authors: Rakesh Verma
Seth G.L. Bihani S.D. college ,
sri ganganagar

1. Introduction
The discovery of a variety of pharmaceuticals in surface, ground, and drinking waters around the country is raising concerns about the potentially adverse environmental consequences of these contaminants. Minute concentrations of chemicals known as endocrine disruptors, some of which are pharmaceuticals, are having detrimental effects on aquatic species and possibly on human health and development.

About Author:
ANAND GAURAV, SMITA SINGH
M.Pharm,
Assistant Professor

Abstract:
The importance of the phthalazine as a nucleus with medicinal properties is well established, since many decades. This nucleus possess potent anticonvulsant activity with high protection index value that why this property is use for the treatment that are related to mental disorder, like seizures.  Phthalazine and its derivatives possessing triazines nucleus has attracted great attention in recent years due to wide variety of biological activity particularly anticonvulsant activity keeping in view the continuing interest in phthalazine and its derivatives. The present study is aimed at synthesizing safer and effective anticonvulsant triazolo-phthalazine derivatives to evaluate them for anticonvulsant activity.

About Author: Alka Lohani
M.Pharm (Pharmaceutics)
department of pharmaceutical sciences bhimtal campus
kumaun university nainital

Abstract:
Inconvenience of administration and patient compliance are gaining significant importance in the design of dosage forms. Difficulty in swallowing (dysphagia) is common among all age groups, especially in elderly and pediatrics. Ciprofloxacin hydrochloride is an orally administered antibacterial agent. The objective of this study was to develop ciprofloxacin hydrochloride soft gel using sodium alginate as a gelling agent and sodium citrate as a source of cation. Gels are formed by aggregation of polymers with minimum two components; the gelling agent and the fluid component.  Different batches were prepared using three different concentrations of sodium alginate (0.1, 0.4, and 0.8%). The consistency of sodium alginate gel was dependent on the concentration of, sodium alginate, sodium citrate and co-solute. The results of dissolution study of soft gel F3 containing 0.4% sodium alginate and 0.3% sodium citrate revealed that Ciprofloxacin hydrochloride was 85% released in 45 min. and possessed acceptable sensory characteristics when evaluated by human volunteers. Short term stability study carried out for four weeks at different temperatures (0°C and room temperature) showed no considerable changes in performance characteristics of developed optimized formulation.

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The Institute of Himalayan Bioresource Technology is one of the National Institute under the Council of Scientific & Industrial Research which is an autonomous body. It is located on a 250 acres of land with the backdrop of snow-covered peaks of Dhauladhar Range in salubrious climate.

The vision of NMIMS University is to define the 21st century technological and management research. Hence the goal for NMIMS University is to encourage excellence in research and publication activities. Research is a precursor to discovery and innovation.

Government of India has set up six new National Institutes of Pharmaceuticals Education and Research (NIPERs) under the aegis of Ministry of Chemicals and Fertilizers, Department of Pharmaceuticals, at Ahmedabad. Guwahati, Hyderabad, Hajipur, Kolkata and Rae Bareli. These are presently being run with the help of Mentor Institutes. The Institutes are required to be established on their own.

R. C. Patel Institute of Pharmaceutical Education & Research formerly known as  R. C. Patel College of Pharmacy was established in 1992 with the primary objective of providing value based health and technical education to aspiring candidates and mould out them citizens who will make India proud in the 21st Century. The institute also aims for all-round development of the students to help them realize their full potential and career goals.

Meyer,an associate of London based multinational Vitabiotics Ltd.,is a rapidly growing Pharma Co. in India. Leading pharmaceutical manufacturer, founded in 1982 .,in technical collaboration with OMEGA-MEYER Ltd Jersey( Br. Isles). H.O. based in THANE

Post: PMT- Trainee

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About Authors: Seema Meena, Anil Kumar and Shikha Chauhan
a) Amity Institute of Pharmacy, Amity University, Noida,-201301, India.
b) Neuropharmacology division, University Institute of Pharmaceutical Sciences, UGC Centre for Advance Studies, Panjab University, chandigarh-160014, India.

Abstract:
Neuropathic pain represents a real clinical challenge because of its severity, chronic nature, and inadequate drug therapy. Recently, nitric oxide pathway has been proposed in the pathogenesis neuropathic pain like conditions. Curcumin is a well known for its antioxidant and medicinal values. The objective of the present study was to explore possible nitric oxide mechanism in the protective effect of curcumin against sciatic nerve ligation induced behavioral and biochemical alterations in rats.Sciatic nerve ligation was performed in Wistar rats. Various behavioral parameters (thermal hyperalgesia, cold allodynia) followed by assessment of biochemical parameters (lipid peroxidation, reduced glutathione, catalase, and nitrite) both on sciatic nerves and brain. Sciatic nerve ligation significantly caused thermal hyeralgesia, cold allodynia and oxidative damage as compared to sham (Sciatic nerve without ligation) and naïve animals. Chronic administration of curcumin (20 mg/kg, po) significantly reversed behavioral alteration and attenuated oxidative damage in both sciatic nerve and brain as compared to control.  Further, L-NAME (5 mg/kg) pretreatment with curcumin (10 mg/kg, po) potentiated protective effect of curcumin as compared to their effect per se. However, L-arginine (100 mg/kg) pretreatment with curcumin (10 mg/kg, po) significantly reversed the protective effects of curcumin. Result of present study suggests that nitric oxide mechanism could be involved in the protective effect of curcumin against sciatic nerve ligation induced behavior and biochemical alterations in rats.

About Author: Sayani Chakrabarti
M.Pharm in Pharmaceutical Chemistry
SIPS, Jharpokharia
Mayurbhanj-757086
Orissa

ABSTRACT
Benfotiamine (rINN, or S-benzoylthiamine O-monophoshate) is a synthetic S-acyl derivative of thiamine (vitamin B1). It has potential anti oxidant effect. A three-armed, randomized, multicentre, placebo-controlled double-blind study was used to examine the efficacy of benfotiamine vs a combination containing benfotiamine and vitamins B6 and B12 in out-patients with severe symptoms of alcoholic polyneuropathy (Benfotiamine in treatment of Alcoholic Polyneuropathy. BAP I). The study period was 8 weeks and 84 patients fulfilled all the prerequisite criteria and completed the study as planned. Benfotiamine led to significant improvement of alcoholic polyneuropathy. Vibration perception (measured at the tip of the great toe) significantly improved in the course of the study, as did motor function, and the overall score reflecting the entire range of symptoms of alcoholic polyneuropathy. A tendency toward improvement was evident for pain and co-ordination, no therapy-specific adverse effects were seen.

Rajat Pharmachem Ltd. is a Formulation plant located at Ankleshwar, Bharuch - Dist, Gujarat. The company is engaged in the manufacturing of formulation like Tablets, Capsules, Oral Powder & Effervescent Tablet.
The the company is WHO-GMP, NAFDAC - Nigeria, FDB Ghana, ISO 9001:2008, ISO 22000:2005 approved company.
The company is having vast range of tablets, capsules, powder and lataste technology of effervescent tablet manufacturing.

Thomson Reuters is the leading source of intelligent information for the world's businesses and professionals, providing customers with competitive advantage.

The Scienomics Group (TSG) is a full-service communications company based in Greenwich, CT, with offices in New York and San Francisco that provides medical education services globally to support pharmaceutical products and devices/diagnostics throughout a product’s lifecycle. Services offered by TSG include scientific message development, gap analyses, strategic planning, publications and program planning and implementation, live events, speakers’ bureau, and much more.

Wallace Pharmaceuticals is a progressive, professionally managed and growing pharmaceutical company with a special focus on Antibiotic, Anti -infective, Analgesic, Anti-inflammatory, Antiacne, Paediatric, Orthopaedic, Dermatology and Diabetic segments.

Post: Medical Representative

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Zydus Cadila is a fully integrated, global healthcare provider, with strengths all along the pharmaceutical value chain. With a core competence in the field of healthcare, Zydus Cadila provides total healthcare solutions ranging from formulations, active pharmaceutical ingredients (API) and animal healthcare products to wellness products.

Guardian Pharmacy is a six-year-old retail chain of Pharmacy, Wellness, Health and Beauty Stores. Based on the premise of service and reliability the company currently serves 7.5 million customers annually and is India’s fastest growing pharmacy retail chain with more than 200 outlets.

Nectar Lifesciences Ltd., Chandigarh, India a US$ 200 million company engaged in the business of manufacturing & marketing products in lifesciences particularly Antibacterial I.e. Cephalosporins with 40% market share in API's I.e. 3rd & 4th generation Cephalosporins out of India.