INSIGNIFICANT EFFECT OF SUPERPOROUS HYDROGEL PARTICLES AS A SUPERDISINTEGRANTS IN FAST DISPERSIBLE TABLETS OF ACECLOFENAC
About Authors:
Dr. HV Chavda1*, Ms. SK Patel1, Dr. CN Patel1,
1Shri Sarvajanik Pharmacy College,
Nr. Arvind Baug, Mehsana, Gujarat-384001, India.
*hvchavda@sspcmsn.org
ABSTRACT
Background: In present investigation an attempt has been made to formulate a fast dispersible formulation of aceclofenac using three different superdisintegrants. The role of superporous hydrogel particle as a superdisintegrant was checked for its further future applications. Materials and Methods: The selection of superdisintegrants viz. poly (Acrylamide-co-Acrylic acid) superporous hydrogel particles, cross carmellose sodium and starch 1500 were done using the simplex lattice design. Tablet formulations were prepared using direct compression technique and evaluated for hardness, weight variation, friability, drug content, dispersion time, wetting time, water absorption ratio and in vitro drug release studies. Results and Discussion: The dispersion time of all formulation showed less than 21 second. Superporous hydrogel particles did not showed significant improvement in dispersion time compared cross carmellose sodium and starch 1500. The in vitro drug release from batch F7, tablets containing equal proportions of superdisintegrants showed fast dispersion and fast release compared to other batches. Batch F7 was stable for the period of six months at 40 oC / 75 %RH. Conclusions: Combination of three superdisintegrants was more suitable in fast dispersible tablet formulation of aceclofenac. The superporous hydrogel particles showed equivalent effect as a superdisintegrant, however process complexity of its preparation suspects its role or an option as a superdisintegrant in fast dispersible or immediate release formulations.

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