Wallace Pharmaceuticals is a progressive, professionally managed and growing pharmaceutical company with a special focus on Antibiotic, Anti -infective, Analgesic, Anti-inflammatory, Antiacne, Paediatric, Orthopaedic, Dermatology and Diabetic segments.

Post: Product Manager

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NEXTUS SOLUTIONS is a professionally managed organization engaged in offering highly acclaimed consulting, Training and Placement. With our in- depth expertise and rich experience in the field of domestic as well as international level, we have been serving aspiring candidatesand organizations in the most professional way.

About Authors:
DHAVAL PATEL ^*[1], Dr. PANKAJ SHAH ^[2]
1 School of Pharmaceutical Sciences,
Jaipur National University, Jaipur -302025, (Rajasthan.), India
² institute of kidney disease and research center,
Civil hospital, Ahmedabad (Gujarat), India

Abstract:
Inpresent study, comorbidities and laboratory abnormalities of telbivudine was analysed in hepatitis b patients. Clinical data were collected from hepatitis b patients that presented with laboratory abnormalities to telbivudine. We examined 100 patients of hepatitis b  who treated with telbivudine in i.k.d.r.c, civil hospital, Ahmedabad from January 2009 to February 2011, out of these twenty patients had used other nucleoside analogue in past. The main laboratory abnormalities were elevation of creatine kinase, elevation of ALT and elevation of AST. Hypertension was the major comorbidities with the hepatitis b.The laboratory abnormalities were related to telbivudine, but the biological mechanism of the reaction is not clear.

About Author: Rinki Verma (Research fellow)
Center of Experimental Medicine and Surgery,
Institute of Medical science
Banaras Hindu University
Varanasi - 221005

Abstract:
In 1965 ,  firstly fragility was reported in cells of  a femeal previously irradiated and described  as non-random human chromosome called “ Fragile sites”  are heritable specific chromosome loci that exhibit an increased frequency of gaps, poor staining, constrictions or breaks when chromosomes are exposed to partial DNA replication inhibition. They constitute areas of chromatin that fail to compact during mitosis. They are classified as rare or common depending on their frequency within the population and are further subdivided on the basis of their specific induction chemistry into different groups differentiated as folate sensitive or non-folate sensitive rare fragile sites, and as aphidicolin, bromodeoxyuridine (BrdU) or 5-azacytidine inducible common fragile sites. Most of the known inducers of fragility share in common their potentiality to inhibit the elongation of DNA replication, particularly at fragile site loci. There are seven non-similar folate sensitive (FRA10A, FRA11B, FRA12A, FRA16A, FRAXA, FRAXE and FRAXF) and two non-folate sensitive (FRA10B and FRA16B) and  have been molecularly characterized. Due to dynamic mutation formed DNA repeat sequences and  involving the normally occurring polymorphic CCG/CGG trinucleotide repeats at the folate sensitive and AT-rich minisatellite repeats at the non-folate sensitive fragile sites. These rare fragile site FRAXA is the most important fragile site as it is associated with the fragile X syndrome significant to the clinical side and also explained the predisposition of tumors.

Piramal Healthcare Limited A major force in the pharmaceuticals and healthcare segment, Piramal Healthcare Limited, incorporating Healthcare Solutions & Pharma Solutions, has an unequivocal vision – to become the most admired pharmaceutical company, with leadership in market share and profits.

Sigma Institute of Technology and Engineering trust is a registered charitable trust, having registration Number E/6432, and dated 8/1/2004, under public trust Act. The trust registered at Vadodara, has a mission to impart quality education that empowers generation next to build better environment for all. We at the trust follow the footsteps of Sir Sayajirao Gaikwad  in furthering this vision that education reaches all and helps build better tomorrow for all.

ANSWERS of Previous PharmaQUIZ-28:

1.A    2.C    3.A    4.C    5.B

6.B    7.D    8.D    9.A    10.A

Biocon is a research-driven, global healthcare company with a strong matrix of capabilities along the biopharmaceutical value chain. Focusing on unmet medical needs in cancer, diabetes and inflammatory diseases, it offers novel therapies on a platform of affordable innovation.
Biocon together with group companies employs more than 2500 employees with approxmimately Rs 1,000 crore turnover and is expected to grow further during the current financial year.

IIT Bombay, set up by an Act of Parliament, was established in 1958, at Powai, a northern suburb of Mumbai. Today the Institute is recognised as one of the centres of academic excellence in the country. Over the years, there has been dynamic progress at IIT Bombay in all academic and research activities, and a parallel improvement in facilities and infrastructure, to keep it on par with the best institutions in the world. Institutes in positions of excellence grow with time.

The National Centre for Cell Science (NCCS) took birth as National Tissue Culture Facility in March 11, 1986 with a mandate of basic research, teaching & training, and as a national repository for cell lines/hybridomas etc.  The centre is located in the midst of academically enriched environment of University of Pune campus, Pune.

Radico Remedies is premier Pharmaceutical manufacturing company in North India with manufacturing unit in excise free area of Barotiwala ( BADDI) near Pinjore having and GMP, ISO 9001 certifications and WHO compliance, and head office in Delhi.

Kredent Academy is the unique concept where industry professionals have taken the onus of creating a strong knowledge bank in their area of expertise by bridging the gap between theory and practice and by incorporating the practical mode of imparting training.

About Authors:
S.Pradeep kumar, D.Prathibha, Dr.N.L.Gowrishankar, R.Parthibarajan, L.Matsyagiri
Department of Pharmaceutics, 
Swami Vivekananda Institute of Pharmaceutical Sciences,
Vangapally (V), Yadagirigutta (M), Nalgonda,
Andhra Pradesh, India.

ABSTRACT
The goal of the present investigation was to formulate and evaluate fast dissolving tablets (FDT) of Rosiglitazone maleate. To improve patient compliance, mouth dissolving tablets have emerged as an alternative to conventional dosage forms. Rosiglitazone and Sulfonylurea are given in combination for treatment of type 2Diabetes Mellitus for long term therapy. During this therapy, it is observed that there is uncontrolled increase of blood glucose level, andthe drug undergoes hepatic metabolism. Therefore, mouth dissolving tablets of Rosiglitazone were prepared to overcome this unusual problem and to make use of the inherent advantages of the novel drug delivery system.The tablets were prepared by using direct compression method using Superdisintegrants. Rosiglitazone mouth dissolving tablets containing Cross povidone & Cross carmellose sodium in the ratio 1:1 showed maximum drug release. Formulations were subjected to stability studies. Formulations are stable for 28 days at 40 oC / 75 % RH with insignificant change in the hardness, disintegration time and in vitro drug release pattern.

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Established under the Act Of State Government- “The Rajasthan University Of Health Sciences Act, 2005” (Act No. 1 of 2005)”on 25 day February, 2005, the University aims to disseminate and advance knowledge in medical and health sciences. The University provides academic and research facilities in various streams to the students studying in various Government Colleges (Medical, Dental, Nursing, Pharmacy & Paramedical) and private colleges/institutions affiliated to this University.

About Author: Rinki Verma (Research fellow)
Institute of Medical science (CEMS)
Banaras Hindu University
Varanasi - 221005

Abstract:
Gallbladder cancer is a comparatively rare cancer and has poor outcome due to their anatomy and location. It has peculiar geographical distribution being common in central and South America, central and eastern Europe, Japan and northern India; it is also common in certain ethnic groups e.g. Native American Indians and Hispanics (Kapoor VK, McMichael AJ ,2003. It is fifteen uncommon cancers in the world with high mortality rate. The diagnosis is made very late due to its silent course. The majority of patients have advanced disease at the time of presentation which carries a poor prognosis. The modes of spread of gall bladder carcinoma are direct, lymphatic, vascular, neural, intraperitoneal and intraductal. Ultra Sound, CT and MRI are helpful in diagnosis and staging of the disease. Surgery remains the mainstay of treatment and chemotherapy has a very limited role.

About Author:
Amol.A.Dambal,
Department of Pharmacognosy and Phytochemistry
Govt. College of pharmacy, Kathora naka,
Amravati-444604. (M.S.), INDIA.

ABSTRACT:
The herbal remedies have been employed in various medical systems for the treatment and management of different diseases. The plant Terminalia arjuna has been used in different system of traditional medication for the treatment of diseases and ailments of human beings. The plants contain Arjunilic acid, Triterpine glycosides like Arjunetosides I, II, III, IV, Arjunine and Arjunetein. The bark is rich in Saponnins, natural anti-oxidants (flavonoids-arjunone,arjunolone,leteilin), gallic acid, ellagic acid , phytosterols, rich in minerals like ca,  mg, zn and co, reducing sugars & coloring matter. It has been reported as Cardio tonic, Hepato-protective, Immunomodulatory, Antihyperglycemic, Antihyperlipidemic, Analgesic and Anti-Inflammatory, Antibacterial and Antiulcer properties.The current study is therefore carried out to provide requisite phytochemical and Pharmacological detail about the plant. The plant is cultivated in different parts of India on a small scale at present However; systematic information on different aspects of this species is not available. In this review, an attempt has been made to present this information.

About Authors:
Ms. Shilpa G. Lodha¹,  Vanita Nimje², Ramzan Virani^3
1 Department of Biotechnology,
Agnihotri College of Science, Ram Nagar,
Wardha 442001, India.
² Department of Biotechnology,
Jankievi Bajaj college, Arvi Naka,
Wardha 442001, India.
³ Department of Biology,
Shivramji Moghe College of Science,
Panharkawada- 445 302, India.

Abstract
Many types of Cancer and Malingancy are known, in that Waldenstrom’s macroglobulinemia is rare cancer of an uncommon lymphoproliferative disorder characterized primarily by bone marrow infiltration and IgM monoclonal gammopathy. It should be considered a distinct clinicopathological entity rather than a clinical syndrome secondary to IgM secretion. The concentration of monoclonal IgM can vary widely in Waldenstrom’s macroglobulinemia and it is not possible to define a concentration that reliably distinguishes it from monoclonal gammopathy of undetermined significance (MGUS).  Besides having lots of diagnosis method, there is no single accepted treatment for Waldenstrom’s macroglobulinemia.  Commonly used treatment includes the monoclonal antibody rituximab, sometimes in combination with chemotherapeutic drugs such as chlorambucil, cyclophosphamide, or vincristine or with thalidomide. We have to find out the successful and low cost methods to cure Waldenstrom’s macroglobulinemia.

ANSWERS of Previous PharmaQUIZ-27:

1.A    2.D    3.A    4.D    5.A

6.B    7.C    8.A    9.B    10.A

ENGAGEMENT OF PARA-MEDICAL STAFF ON CONTRACT BASIS AGAINST VACANCIES EXISTING IN PARA -MEDICAL CATEGORY OF NORTHEAST FRONTIER RAILWAY, MALIGAON & ITS DIVISIONS– THROUGH WALK-IN INTERVIEW.