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ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF SIMVASTATIN BY TERNARY SOLID DISPERSION TECHNIQUE

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ABOUT AUTHORS:
Shete Reshma S.1*, Gadhave Manoj V.2, Gaikwad D. D.3
1Department of Quality Assurance Techniques,
2Department of Pharmaceutics,
3Department of Pharmaceutics,
VJSM’S Vishal institute of pharmaceutical education and research, Ale, Pune, Maharashtra, 412411
*reshma.s.shete@gmail.com

ABSTRCT
Simvastatin is a poorly soluble drug exhibiting poor dissolution pattern. Simvastatin, PEG 6000 & Poloxamer 407 solid dispersions were prepared with a view to study the influence of polymer on solubility and dissolution of this poorly soluble drug Simvastatin. Solid dispersions of Simvastatin were prepared using different ratios of PEG 6000 & Poloxamer 407 as carrier by, solvent evaporation method. They were evaluated for percentage yield, drug content, FTIR spectral studies, DSC, XRD, solubility, and in-vitro dissolution. The solubility profile indicated that there is increase in solubility of Simvastatin when polymer concentration is increased. The solid dispersion complex of drug (1:5:5 ratios) was giving better dissolution profile as compared to pure drug and other solid dispersions. This in turn can improve the bioavailability. FT-IR, DSC shows the compatibility of drug and carrier.

Walk in interview for Project assistant level II in CSIR-CSMCRI

The Discipline of Marine Biotechnology and Ecology of CSIR-CSMCRI, Bhavnagar is actively engaged in multidisciplinary research in frontier areas of modern biology and biotechnology such as stress genomics & proteomics, transgenic, plant-microbe interactions, metagenomics, marine biotechnology, adaptation biology, etc. We are looking for young, talented & motivated persons (M.Sc. in Botany / Plant Biotechnology / Biotechnology) for an ongoing project “Clonal Propagation of Elite Female Date Palm (Phoenix dactylifera L.)”. The details are as under :

Post: Project assistant level II (01)
Upper age limit 28 years as on interview date

Opening for Associate Analyst in Novartis

Novartis (NYSE: NVS) is a world leader in the research and development of products to protect and improve health and well-being. The company has core businesses in pharmaceuticals, vaccines, consumer health, generics, eye care and animal health.
Headquartered in Basel, Switzerland, Novartis employs nearly 115 000 people in over 140 countries worldwide to help save lives and improve the quality of life. The Group is present in India through Novartis India Limited, listed on the Mumbai Stock Exchange and its wholly owned subsidiaries Novartis Healthcare Private Limited, Sandoz Private Limited and Chiron Behring Vaccines Private Limited.

Post: Associate Analyst

Opportunity for Senior Clinical Data Coordinator in Quintiles

Quintiles is the only fully integrated biopharmaceutical services company offering clinical, commercial, consulting and capital solutions worldwide. Our network of 23,000 engaged professionals in 60 countries around the globe works with an unwavering commitment to patients, safety and ethics — ensuring a higher level of healthcare for people. For our biopharmaceutical customers, we help them navigate risk and seize opportunities in an environment where change is constant.

Post: Sr. Clinical Data Coordinator-1420095

AN OVERVIEW ON BENZOTHIAZINONE ANALOGS AS ANTITUBERCULAR DRUGS

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ABOUT AUTHOR:
Mohammad Asif
Department of Pharmacy, GRD(PG) Institute of Management & Technology,
Dehradun, (Uttarakhand), 248009, India
aasif321@gmail.com

ABSTRACT:
The reappearance of tuberculosis and the rush of multidrug-resistant clinical isolates of Mycobacterium tuberculosis have reaffirmed tuberculosis as a key public health concern. Describe findings on the pharmacological status of Benzothiazinones as new agents that are being developed as antitubercular drugs. Benzothiazinones act by targeting the enzymes responsible for the formation of arabinans that are essential parts of the cell wall. In view of their novel mechanism of action, these drugs appear promising as anti-TB drugs and considered to be promising candidates for future development.

GlaxoSmithKline plc (GSK) announces that its three-part transaction with Novartis has completed today. As a result of this transaction, GSK has acquired Novartis’s global Vaccines business (excluding influenza vaccines) for an initial cash consideration of $5.25 billion; has created a new world-leading Consumer Healthcare joint venture with Novartis in which GSK will have majority control and an equity interest of 63.5%; and has divested its Oncology business for an aggregate cash consideration of $16 billion.

Walk in for B.Pharm, M.Pharm as Junior Executive, Junior Scientific Assistant, Senior Lab Assistant in ODCL

Orissa Drugs & Chemicals Limited is conducting Walk in Interview for the posts of Jr. Executive (Marketing), Jr.Scientific Asstt.(QC), Sr.Lab.Asstt(QC) & Supervisor (Prodn.) purely on contact basis. Eligible candidates are invited to appear for walk-in-interview on 16th &17th March, at ODCL Bhubaneswar. For Eligibility criterion, Qualification, Experience, Age & Remuneration etc.

Post: Junior Executive, Junior Scientific Assistant, Senior Lab Assistant

National Institute of Pharmaceutical Education and Research inviting applications from M.Pharm candidates for post of Junior Research Fellow

National Institute of Pharmaceutical Education and Research (NIPER) is the first national level institute in pharmaceutical sciences with a proclaimed objective of becoming a centre of excellence for advanced studies and research in pharmaceutical sciences. The Government of India has declared NIPER as an 'Institute of National Importance'. It is an autonomous body set up under the aegis of Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Government of India. The Institute is conceived to provide leadership in pharmaceutical sciences and related areas not only within the country, but also to the countries in South East Asia, South Asia and Africa. NIPER is a member of Association of Indian Universities and Association of Commonwealth Universities.

Post: Junior Research Fellow

Require Pharmacist in TNSACS

Tamil Nadu State AIDS Control Society (TANSACS), Chennai invites applications from eligible Candidates with the qualifications / requirements mentioned against each along with two recent passp ort size photographs with Photostat copies of Certificates for t he following contractual posts on Consolidated Salary. These posts are Purely temporary, not likely to become permanent and co - terminus with the project. Age limit: upto 60 Yrs., as on 01-03-2015.

Post: Pharmacist

Opening for Pharmacists (40 Posts) in OSMCL - agency for the Department of Health and Family Welfare

OSMCL has been incorporated on 8th November 2013 under the Companies Act., 1956, in pursuance to the Government Resolution No. 8844 dated 26th June 2013, to act as an independent procurement agency for the Department of Health and Family Welfare, Government of Odisha. The OSMCL has the key functions like timely procurement of quality medicines, surgical, equipment, instruments, furniture etc.through fair, transparentand competitive bidding process.

Post: Senior Pharmacist (Warehouse)

Walk in interview on B.Pharm- Intern in HealthKart | 10 Opening

HealthKart.com is India's largest online health & fitness store for men, women, and kids. Shop online from the latest collections of health, fitness, beauty, sports, eye care, parenting and similar products featuring the best brands.

Post: Intern

Cow urine and related ayurvedic preparations are gaining popularity among the modern population. In Ayurveda, these formulations are therapeutically important in Krimi Roga, Kushtha, Kandu, Shoola, Gulma, Udara Roga, Anaha, Shotha, Pandu, Kamala, Vasti Roga, Kasa, Shavasa, Atisara, Mutraroga etc. Cow urine is ingredient of several Ayurvedic formulations and also used as adjuvant with medicinal formulations and for pharmaceutical processing called Shodhana (Purification) and Bhavana (Triturition) of medicinal materials.

Recruitment through Walk in interview for B.Pharm- QA, QC, Production as Production Executive, Chemist, Junior Chemist in IDPL

M/s. Indian Drugs & Pharmaceuticals Limited (I.D.P.L.) is a Central Public Sector Undertaking wholly owned by the Govt. of India engaged in manufacture of pharmaceuticals. A Unit of I.D.P.L. situated at Rishikesh requires to engage trained and experienced professionals in following fields on a fixed term contract basis initially for a period of one year which can be extended further on performance basis.

Post: Production Executive, Chemist, Junior Chemist

Kalyan Dombivli Municipal Corporation invites Pharmacist | 17 Posts

Welcome to Kalyan Dombivli Municipal Corporation Enterprise Information Portal (KDMC-EIP). In our endeavor to offer quality Citizen Services, we are now happy to bring the Corporation at your finger tips through this portal. We are sure that the citizen of the new age will draw immense benefits from the new Point & Click KDMC.

Post: Pharmacist

Walk in interview for Senior Research Fellow (Pharmacongnosy) in CCRAS

It is proposed to engage the services of the following personnel initially for a period of one year which may be curtailed or extended at the discretion of the competent authority on consolidated payment mentioned against each category. The written test will be held on the dates indicated against each category and only those candidates, who qualify the written test, will be interviewed on the same day. The requirement and other details are as under:-

Walk in interview for Assistant Manager, Senior Executive, Executive, Technicians, Plant Operators- QC, QA, Production in Alembic Pharmaceuticals

Alembic Pharmaceuticals Limited, with an established presence in the Indian pharma industry has a proud, historical track record going back over 100 years.
To realize our ambitious plans, we call upon dynamic, result oriented team members to join our API & Formulation manufacturing unit located at PANELAV, near Vadodara (Gujarat).

Post: Assistant Manager, Senior Executive, Executive, Technicians, Plant Operators

Applications are invited for Professor, Associate Professor, Assistant Professor in Arvind Gavali College of Pharmacy

Applications are invited from eligible candidates for the following posts to be filled in College’s M.Pharmacy section.

Post: Professor, Associate Professor, Assistant Professor

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No.of post: 03

Required for Pharmacist in ONGC

ONGC, Assam Asset, Nazira intends to engage following Paramedics on contract basis for a period upto 30.06.2016 on consolidated honorarium with the essential qualification as mentioned against each post. Job is purely on Contract basis and doesn’t carry any liability on ONGC for regular appointment at any stage. Interested and eligible candidates are requested to appear for Walk-in-interview along with prescribed application format duly filled in as given here under on the date and venue mentioned below :

Post: Pharmacist

NHSRC intends recruiting Consultant-Health Care Technologies (Medical Devices & Diagnostics)

National Health Systems Resource Centre (NHSRC) has been set up under the National Health Mission (NHM) as an autonomous registered society, to channelize technical assistance and capacity building support to the states for strengthening the public health system. The NHSRC is also mandated to contribute towards National strategic health planning and programme design. Work at NHSRC is organised around multiple divisions, namely - Community Processes, Quality Improvement, Public Health Planning, Public Health Administration, Healthcare Financing & Healthcare Technology, HMIS and Human Resources for Health.

NHSRC intends recruiting Consultant-Health Care Technologies (Medical Devices & Diagnostics) purely on contractual basis.

Post: Consultant-Health Care Technologies (Medical Devices & Diagnostics)

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