Biochemistry of Prostaglandins and Cyclooxygenase in Cancer
PharmaTutor (September- 2014)
ISSN: 2347 - 7881
(Volume 2, Issue 9)
Received On: 16/06/2014; Accepted On: 27/06/2014; Published On: 01/09/2014
AUTHORS: Rajwinder Rattan*, Tapan Behl, Puneet Sudan, Rashi Wanchoo Misri, Dharmender Jaglan
Department of Applied Sciences,
Doaba Group of Colleges, Kharar, Punjab, India.
Colorectal is the third most prevalent form of cancer in the world. Several studies report that prostaglandins are mediators of carcinogenesis cyclooxygenase known as prostaglandin endoperoxidase H synthase. Levels of COX-2 isoenzyme and prostaglandins like PGE2, PGF2 alpha and PGE1 are found to be higher in certain cancers like colorectal carcinoma, squamous cell carcinoma of head and neck, also in certain types of breast cancer. Prostaglandins may contribute to the cancer processes through one or more of several mechanism including increased proliferation, apoptosis, enhanced carcinogen metabolism of immune system. Decreasing the high level of COX-2 and prostaglandins already mentioned has shown to decrease carcinogenesis. The understanding of the regulation of substrate availability and of a regulation (Dysregulation in many neoplasis) of the synthesis enzymes has opened avenues leading to design of isoenzyme specific inhibitors and better cancer strategies.
How to cite this article: R Rattan, T Behl, P Sudan, RW Misri, D Jaglan; Biochemistry of Prostaglandins and Cyclooxygenase in Cancer; PharmaTutor; 2014; 2(9); 46-58