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RNA Interference-weapon against cancer


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PharmaTutor (November- 2015)


Print-ISSN: 2394 - 6679
e-ISSN: 2347 - 7881
(Volume 3, Issue 11)


Received On: 13/05/2015; Accepted On: 03/07/2015; Published On: 01/11/2015


AUTHORS: Shalja Verma, Anand Kumar Pandey*
Department of Biotechnology, Institute of Engineering & Technology,
Bundelkhand University, Jhansi, Uttar Pradesh, India


ABSTRACT: Cancer is the second principal death cause, in the recent scenario 1 out of every 4 people die out of cancer. Not more than 50% advanced cancer subjects live a year ahead. RNA interference (RNAi) a phenomenon which serves for shutting off the expression of a specific sequence has proved itself a finest weapon against cancer. This mechanism involves silencing of the expression of desired mRNA sequence by degrading it using a dsRNA (double stranded RNA) molecule having complementarity to the desired mRNA. However a major challenge in proficient implementation of this therapy against cancer is lack of efficient delivery methods for the dsRNA to the target tissue. Various delivery methods had already been developed for efficient and effective delivery of the dsRNA and many are under trial. This review is going to present the great efficacy of RNAi against cancer and the various delivery methods performing capable work in accurate application of this therapy.


How to cite this article: S Verma, AK Pandey; RNA Interference-weapon against cancer; PharmaTutor; 2015; 3(11); 19-24