Formulation and Design of Metformin Hydrochloride Extended Release Tablets

  • Posted on: 1 November 2014
  • By: admin

 

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PharmaTutor (November- 2014)

 

ISSN: 2347 - 7881
(Volume 2, Issue 11)

 

Received On: 20/08/2014; Accepted On: 10/09/2014; Published On: 01/11/2014

 

AUTHORS: Goundla Uday Bhasker Goud1*, Jakkampudi Sri Venu Prakash1, Avadhanam Pranav Kumar2, Gangi Reddy Sreenivas Reddy2, Manikanta Sai Krishna2.
1Department of Industrial Pharmacy
2Department of Pharmaceutics
Bharat Institute Of Technology, Mangalpally, Hyd, Telangana, India.
gouds.uday04@gmail.com

 

ABSTRACT:
Aim: The current paper was an attempt to design a extended release dosage form of Metformin hydrochloride using various grades of hydrophilic polymers, hydroxy propyl methyl cellulose (HPMC K4M, HPMC K15M, HPMC K100M and HPMC K200M) and MCC.
Materials and Methods:
Laboratory scale batches of 4 tablet formulations were prepared by wet granulation technique. Precompression parameters of the granules were evaluated prior to compression. Tablets were characterized as crushing strength, friability, weight variation, thickness, drug content or assay and evaluated for in-vitro release pattern for 12 hr using Phosphate buffer of pH 6.8 at 37 ± 0.5°C.
Results and Discussion:
The results obtained revealed that HPMC K100M in formulation (F3) was able to sustain the drug release for 12 h and followed the Higuchi pattern quasi-Fickian diffusion. and charged for stability testing, parameters were within the limit of acceptance. There was no chemical interaction found between the drug and excipients during Fourier Transform Infrared Spectroscopy (FTIR).
Conclusion:
Hence it can be concluded that formulation F3 containing HPMC K100M is suitable for development of extended release tablets of Metformin Hydrochloride.

 

How to cite this article: GUB Goud, SVP Jakkampudi, PK Avadhanam, GRS Reddy, MS Krishna; Formulation and Design of Metformin Hydrochloride Extended Release Tablets; PharmaTutor; 2014; 2(11); 112-119

 

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