Development and Validation of Spectrophotometric Method for Simultaneous Determination of Sildenafil Citrate and Dapoxetine Hydrochloride in Their Combined Dosage Formulation

  • Posted on: 1 November 2014
  • By: admin

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PharmaTutor (November- 2014)

 

ISSN: 2347 - 7881
(Volume 2, Issue 11)

 

Received On: 03/09/2014; Accepted On: 09/09/2014; Published On: 01/11/2014

 

AUTHORS: Chetan A. Prajapati, Bhavik S. Patel
Department of Quality Assurance, Shri Sarvajanik Pharmacy College
Nr. Arvind Baug, Mehsana, Gujarat, India
prajapatichetan25@gmail.com

 

ABSTRACT:
A simple, accurate and precise spectrophotometric method has been developed for simultaneous estimation of Sildenafil Citrate and Dapoxetine Hydrochloride in combined dosage form. Simultaneous equation method is employed for simultaneous determination of Sildenafil Citrate and Dapoxetine Hydrochloride from combined dosage forms. In this method, the absorbance was measured at 291 nm for Sildenafil Citrate and 230nm for Dapoxetine Hydrochloride. Linearity was observed in range of 6-42μg/ml and 2-10μg/ml for Sildenafil Citrate and Dapoxetine Hydrochloride respectively. Recovery studies confirmed the accuracy of proposed method and results were validated as per ICH guidelines. The method can be used for routine quality control of pharmaceutical formulation containing Sildenafil Citrate and Dapoxetine Hydrochloride.

 

How to cite this article: CA Prajapati, BS Patel; Development and Validation of Spectrophotometric Method for Simultaneous Determination of Sildenafil Citrate and Dapoxetine Hydrochloride in Their Combined Dosage Formulation; PharmaTutor; 2014; 2(11); 84-88

 

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