Huntington’s Disease: An Update

  • Posted on: 1 July 2014
  • By: admin

 

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PharmaTutor (July- 2014)
ISSN: 2347 - 7881

 

Received On: 09/05/2014; Accepted On: 13/05/2014; Published On: 01/07/2014

 

AUTHORS: Amandeep Kaur
Department of Pharmacology, G.H.G Khalsa College of Pharmacy
Gurusar Sadhar, Ludhiana, Punjab, INDIA
amananny2011@gmail.com

 

ABSTRACT:
Huntington's disease is a complex degenerative disorder that affects the central nervous system. Huntington's disease is an autosomal-dominant, progressive neurodegenerative disorder typically presents during mid-life with a distinct phenotype, including chorea and dystonia, incoordination, cognitive decline, and behavioral abnormalities. HD is caused by an expanded CAG repeat in the gene that encodes the protein huntingtin on chromosome 4; this results in progressive atrophy of the striatum as well as cortical and other extra striatal structures. Since 1993, genetic testing has been available to confirm diagnosis in affected adults and for pre-symptomatic testing in at-risk individuals. The review aims majorly on these areas namely: History, etiology, symptoms, pathophysiology, treatment and other aspects of Huntington’s disease.

How to cite this article: A Kaur; Huntington’s Disease: An Update; PharmaTutor; 2014; 2(7); 47-53

 

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