Antibacterial, Antioxidant and Cytotoxic activities of Trewia nudiflora

  • Posted on: 31 December 2015
  • By: admin

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JANUARY 2016 ARTICLE LIST >>

PharmaTutor (January- 2016)

 

Print-ISSN: 2394 - 6679
e-ISSN: 2347 - 7881
(Volume 4, Issue 1)

 

Received On: 27/08/2015; Accepted On: 31/08/2015; Published On: 01/01/2016

 

AUTHOR:
Yesmin Begum*
Department of Pharmacy,
Southeast University, Dhaka, Bangladesh
*yesumyta@gmail.com

 

ABSTRACT: The aim of the study is to verify the traditional uses of different parts of Trewia nudiflora. Leaves, fruits, twigs & seeds of T. nudiflora were extracted with ethanol to evaluate antibacterial, antioxidant and cytotoxic activities. Antibacterial activity of the ethanolic extracts of different parts of T. nudiflora was revealed by disc diffusion method using kanamycin as standard. The leaf extract showed very good activity against Shigella dysenteriae with 37.5 mm zone of inhibition and moderate activity against Pseudomonas aeroginosa with 16.5 mm. The fruit extract also showed very good activity against Shigella boydii with 22.5 mm zone of inhibition. The twig extract also showed very good activity with 20mm zone of inhibition against Pseudomonas aeroginosa and the seed extract showed moderate antibacterial activity. The antioxidant activity of the extracts was determined by using DPPH spectrophotometrically and ascorbic acid was used as standard. Among all the parts, the twig extract showed highest antioxidant activity having an IC50 value of 35.51 μg/ml. The leaf, twig and fruit extracts showed significant cytotoxicity with LC50 value of 9.17 μg/ml, 10 μg/ml and 10.53 μg/ml, respectively evaluated by brine shrimp lethality bioassay using vincristine sulfate as standard.

 

How to cite this article: Begum Y; Antibacterial, Antioxidant and Cytotoxic activities of Trewia nudiflora; PharmaTutor; 2016; 4(1); 37-41

 

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