Articles

ABOUT AUTHORS:
Bhatt Anjali*, Goshwami Lakshmi,  Papola Vibhooti, Pathak Namita, Rawat Shuveksha
Shri Guru Ram Rai Institute of Technology and Science,
Dehradun 248001, Uttrakhand India

ABOUT AUTHOR:
Akshay Rajgaria
Kanak Manjari Institute of Pharmaceutical Sciences
akshaykrish2007@gmail.com

ABSTRACT
Leptospirosis is a worldwide zoonotic infection with a much greater incidence in tropical regions and has now been identified as one of the emerging infectious diseases. The epidemiology of leptospirosis has been modified by changes in animal husbandry, climate, and human behavior. Resurgent interest in leptospirosis has resulted from large outbreaks that have received significant publicity.

ABOUT AUTHORS:
Shankar Soni¹*, Dr. Puspendra singh Naruka¹, Sunil kumar ola^2
1B N College Of Pharmacy, Udaipur
²Goenka College Of Pharmacy, Laxmangarh
*slsoni85@gmail.com

ABSTRACT
The present work was aimed at formulation development, evaluation and comparative study of the effects of ethyl cellulose in Itopride HCL CR pellets. The controlled release polymers used for the present study were Ethylcellulose N-14 and Ethylcellulose N-20. The formulated pellets were evaluated for various pellet properties, like hardness, bulk density, tapped density, cars index and dissolution rate. Comparative evaluation of the above-mentioned parameters established the superiority of the pellets formulated with Ethylcellulose those formulated with different grades.
The main objective of this work is to develop and explore formulation as sustained release pellets of Itopride hydrochloride.From the literature it was found that different carriers like ethyl cellulose N-20, Ethyl cellulose N-50 were used to prepare controlled release pellets of water soluble drugs. Hence, in the present investigation it is aimed to test the suitability of using ethyl cellulose in the development of gastric retentive systems and for controlling the drug release from the pellets.

About Authors:
Satya Lakshmi.B*, P.Raju vel, Dr. P. Venkateswara Rao, Sindhu.G, Nikil Kumar.K
A.M Reddy Memorial College of Pharmacy,
Narasaraopet, AN University, Guntur.
balla.satya03@gmail.com

Abstract:
The reliability of quantitative assays in determination of drugs in biological fluids using High-performance liquid chromatography with Tandem Mass spectrometric determination (LC-MS/MS) detection methods and the integrity of resulting Pharmacokinetic data may not be absolute, in contrary to common perceptions and possible conjectures. The results may be adversely affected by lack of specificity and selectivity due to ion suppression caused by the sample matrix and interferences from metabolites. The advancements in the past few years and new technologies introduced can be used in enhancing LC-MS/MS Bio-analytical method development by reducing matrix effects. This Article reviews Automated Sample preparation and various extraction techniques like liquid-liquid extraction, Solid phase extraction and protein precipitation which plays an important role in sample preparation and detection by LC-MS/MS. Potential drawbacks during method development and validation are pointed out.

ABOUT AUTHORS:
*¹Charugundla Harini,² K. Sudheer kumar
¹Kakadiya University, Warangal
²Bijupatnaik University of Technology & Sciences, Odisha
charugundlaharini@gmail.com

ABSTRACT
The aim of present research was to develop a fast releasing oral polymeric film, with good mechanical properties, instant disintegration and dissolution, producing an acceptable taste when placed on tongue. Solvent casting method was used to prepare oral films. cetirizine hydrochloride an antihistaminic was incorporated to relieve the symptoms of allergic rhinitis. The polymers selected were HPMC 3cps and PVA. Glycerin was the plasticizer used. Eight batches of films with drug were prepared using different combinations of polymer concentration. The resultant films were evaluated for weight variation, content uniformity, folding endurance, thickness, surface pH, tensile strength, % elongation, % moisture absorption, %moisture loss in vitro disintegration and in vitro dissolution. The optimized films have disintegrated within 28-60sec. The percentage release was varying with concentration of polymer. The films made with HPMC3cps 200 mg released 98.5% of drug in 2min, which was the best release amongst all.

About Authors:
Abhisek Shukla*, Dr. Valluru Ravi
Pharmaceutical Regulatory Affairs group, Dept. of Pharmaceutics,
JSS College of Pharmacy, JSS University,
Sri Shivarathreeshwara Nagar, Mysore-570015, Karnataka, India.
abhishekjsscp@gmail.com

About Author:
Buddhi Bal Chidi
Department of Pharmacy,
Maharajgunj Medical Campus, Institute of Medicine,
Tribhuvan University, Kathmandu, Nepal
buddhibal_chidi@iom.edu.np

ABOUT AUTHOR:
Mr. Ripal Mistry
M.pharm, Indubhai Patel College Of Pharmacy & Research Center,
Dharmaj
Rx.ripalmistry@gmail.com

DEFINATION: