The main animus of a drug is to enhance human happiness by elimination or suppression of of disease and symptoms and to improve the quality of life. Although death is inevitable. But the drug facilitate in reducing health related human suffering and gives a shape to our lives with new hopes, aspirations and remnant of dignity.
Review:
To give a healthy/safer life in the planet is an epimyth of the Pharmaceutical Sciences. From the Pharmacological point of view the main S.O.P of a drug Is to dispense its therapeutic effect inside the body and Should get remove from the body as soon as possible. So in this context BioTransformation hasplayed an essential role in eliminating the toxic metabolites of the drug from the body. Generally Biotransformation it is a process by which drugs which are non-polar in nature get converted into polar form literally means water soluble form. So that they can be reabsorb in the renal tubule. There are different pathways of drug excretion which includes liver, kidney, and urine.
Among this liver is the important route of xenobiotics Metabolism as liver is composed of variety of metabolizing enzymes which includes cytochrome P- 450. The ability of liver to metabolize a substance in First pass is called first pass metabolism. As we have Discuss in the above paragraph that polar drugs which are lipid profile drugs need to be converted into water soluble for the better efficacy of the physiological function of the body. This statement is the only side of coin. But in the other side of the coin is that lipid profile analogue of drug has an profound effect in the Gastrointestinal Tract as they dissolve easily. Since the Cell membrane is made up of lipoidal matrix of cells. But in the due course of time it will precipitate Carcinogenic activity. The main epitome of the Xenobiotic metabolism the other term for the Biotransformation is to protect the body from the obnoxious effect of the drug. This process is an moiety of the elimination technique which is an part of the pharmacological process. This xenobiotic metabolism has widens the horizon of the pharmafield in the different aspects. It help us toaccess the efficacy of drugs and it has been able to produce the drug moiety with enhanced therapeutic activity in the form of prodrugi.e Chloramphenicol antibiotic is converted into Chloramphenicol palmitate which is administer in paediatric oral suspension. The entire cycle of the xenobiotic metabolism depends upon four pillars of the pharmacological system which includes A D, M,E. These four factors are interrelated to each other.
Conclusion:
This type of biological process is always govern by the law of nature. So we can predict the process but cannot clearly confine it. As the nature is smart enough to beguile the men of Science.
References: BIOPHARMACEUTICS by D.M BRAHMANKAR.
About Authors:
Piyush Parasar
B.Pharm, Department, Institution and Institutional
Care hospital banjara hills Hyderabad- 500034, India
piyush.parasar@gmail.com
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