Articles

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About Authors:
Vanraj Thakor¹*, Jalpa Kher², Fenil Bhayani¹, Bhavini Atodaria¹, Malleshappa Noolvi^1
1Shree Dhanvantary college of pharmacy, Kim, Surat, Gujarat, India.
²Ashok & Rita Patel institute of Biotechnology, New Vallabh Vidyanagar, Gujarat, India
vanraj7777@gmail.com, jkher3333@gmail.com

Abstract
Aromatase and 17-ßHSD inhibitors are main target of pharmacological interest for the treatment of estrogen dependent cancers. Chalcones, Coumarins, Flavones, Isoflavones have been reported for such inhibition and are used for treatment of breast tumors. So in this topic, Flavone derivatives containing Imidathiadiazole, Thiadiazole, Triazole and benzimidazole hetrocycles synthesised by using simple laboratory reagents like 2-Hydroxy Acetophenone and 4-Hydroxy Benzaldehyde to convert chalcone leads to formation of Flavones by cyclazation using Microwave and followed by attachment of different hetrocycles to form Flavone derivatives and charactrarized by IR, ¹H NMR, ¹³C NMR spectroscopy and elemental analysis. These Flavone derivatives found to exhibit moderate to high inhibitory activity against Estrogen dependent cancers.

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About Authors:
¹Amita Pandey,²Dr. Shalini Tripathi
¹Research student of Rameshwaram Institute of Technology and Management, Sitapur Road, Lucknow (U.P.)
²Professor of Rameshwaram Institute of Technology and Management, Sitapur Road, Lucknow (U.P.)
pandey.amita2012@gmail.com

Abstract
The AIDS pandemic is one of the most disastrous health and development issue in our world today. Tissue culturing of medicinal plants is widely used to produce active compounds for herbal and pharmaceutical industries. Natural products provide a large reservoir for screening of anti-HIV agents with novel structure and anti-viral mechanism because of their structural diversity. This work reviews in vitro micro propagation techniques and gives examples of various commercially important medicinal plants. Advantages-To produce many copies in any time of the same plants then which may be used to produce plants with better flowers, odour’s, fruits or any other properties of the plants that is beneficial to the human beings. Conclusion- HIV is the most common untreated word wide disease in now a days and Plant tissue culture is most important technique for growing new plant species in proper aseptic condition which are useful for the cure of HIV. Acknowledgement- I would like to record my gratitude to my esteemed respected guide Dr. (Prof.) ShaliniTripathi, Department of Pharmacy, Rameshwaram Institute of Technology and Management

ABOUT AUTHOR
Akshay Rajgaria
Kanak Manjari Institute of pharmaceutical Sciences.
Rourkela, Orissa
akshaykrish2007@gmail.com

About Authors:
Rohit Gujarati, T.M.Pramod Kumar, Parasiya Sachin R.
Pharmaceutical Regulatory Affairs Group, Dept. of Pharmaceutics,
JSS College of Pharmacy, JSS University, S.S Nagar, Mysore-570015, Karnataka, India
rohitgujrati@gmail.com
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Abstract
India has one of the best developed pharmaceutical industries, and produces about 20 per cent of the world’s drugs. Currently many top Indian companies are exporting generic drugs worth Rs 45,000 crore every year to many countries including the US and Europe. But ironically, drugs are beyond the reach of people in India itself, especially the poor, because their prices are very high. It is not that the cost of R&D and manufacturing is high, but that the profit margins are exorbitant and in many cases exploitative, which can be explained by reasons like, lack of proper regulation on price control (except for few DPCO drugs), prescription made by the doctors, lack of awareness in public about the generic drugs.

Government of India is taking certain steps in providing cost effective drugs to the public without compromising with the quality of the medicines. Recently Union government and regulatory bodies appear to be serious in ending the pharma-doctor nexus and curb unethical marketing practices. In its latest effort, the Medical Council of India (MCI) has directed doctors, hospitals and medical colleges to prescribe generic medicines as far as possible. This has not benefited much to the public. This Paper give a brief scenario about the various measures taken by the Govt. of India to scale down the rates of high cost medicines, among which, the concept of “jan aushadhi”, which talks about various measures taken by the Govt. of India on increasing the availability of the generic drugs throughout the country, has been highlighted.

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About Authors:
Patel Rahul R.*, Dr Kanu R Patel, Dr Mukesh R Patel
Department of Pharmaceutics,
Shri B.M.Shah College of Pharmaceutical Education and Research
Dhansura Road College campus Modasa,
Dist:- Arvali. Pin code:- 383315 Gujarat, (india)
rahulrpatel21089@yahoo.com

Abstract
Micro emulsion based Gel formulation provides better application property and stability & makes it dual control release system in comparison to cream and ointment. Topical Microemulsion based gel drug administration is a localized drug delivery system anywhere in the body through ophthalmic, rectal, vaginal and skin as topical routes. Many advantages of gels a major limitation is in the delivery of hydrophobic drugs. So to overcome this limitation an Microemulsion based approach is being used so that even a hydrophobic therapeutic moiety can enjoy the unique properties of gels. Whenever, it is used for fungal disease for topical delivery system, it is good for compare to oral delivery. When gels and Micro emulsions are used in combined form the dosage form are referred as Microemulsion based gel. Skin is one of the most extensive and readily accessible organs on human body for topical administration and is main route of topical drug delivery system. It is prepared by mixing an oil-in-water type or water-in-oil type emulsion with a gelling agent.The use of Micro emulsion based gels can be extended in analgesics and antifungal drugs.

ABOUT AUTHORS:
¹Rashmi Verma, ²Rakesh Tiwle
¹Rungta College of Pharmaceutical Sciences & Research, Bhilai, 491024, C.G
²Shri Laxmanrao Maker Institute of Pharmacy, Amgaon, Gondia, Maharashtra, India- 441902.
rashmi.verma501@gmail.com
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ABSTRACT
In the ancient age COPD has a variable natural history and not all individuals follow the same course about 15-20% of smokers develop clinically significant COPD. It is characterized by the airflow obstruction that is not fully reversible. It is predominantly caused by smoking, particularly occupational exposures, may also contribute to the development of COPD. Chronic obstructive pulmonary disease is diagnosed using a medical device called a spirometer, which measures air volume and flow, the main components of common clinical breathing tests (pulmonary function tests). Long-term exposure to lung irritants that damage the lungs and the airways usually is the cause of COPD. In this article we are focus about and detail review on the COPD.

ABOUT AUTHORS:
Harsh Vyas¹*, Tulsi Upadhyay¹, Nirali Thakkar¹, Kruti Patel¹, Umesh Upadhyay²,
¹Students, ²Faculty of pharmacy
Sigma Institute of Pharmacy,
Bakrol, Vadodara, Gujarat, India
*vyas123harsh@gmail.com, tulsiupadhyay90@gmail.com

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ABSTRACT:
Nanocochleate is a novel lipid based drug delivery system offering systemic and oral delivery of various charged drug molecules. It is formed by negatively charged lipid bilayer. Nanocochleate can encapsulate drugs which are hydrophobic, positively charged, negatively charged and poor orally bioavailable. It is also very much beneficial for oral absorption for peptide drugs that possess a net positive charge. Nanocochleate is beneficial for molecules having binding sites inside the cell. The property that nanocochleates can facilitate cross membrane diffusion for charged and impermeable molecules finds wide application in drug delivery. Nanocochleate have been proven better than liposomes and more compatible with body environment. They differ from liposomes by its structure and compatibility to the body. Liposomes are lipid bilayer with aqueous inner environment and unlike liposomes nanocochleates are having charged lipid bilayer without aqueous environment and are multilayer lipid matrix i.e. Cochleate.

Various methods of its formulation, structure, merits demerits and wide range of application are described in this article.