• 24 November 2013

    DESIGN AND DEVELOPMENT OF SUSTAINED RELEASE MATRIX TABLETS OF FUROSEMIDE

    ABOUT AUTHORS:
    Dr. D. Nagendrakumar, Reddy VM, Keshavshetti G G, Shardor A G*
    Department of Pharmaceutics, SVET’s College of Pharmacy,
    Humnabad- 585 330 (Karnataka).
    ambarish.pharma@gmail.com
    { DOWNLOAD AS PDF }

    ABSTRACT
    Sustained release matrix system are favored because of their simplicity, patient compliance etc, than traditional drug delivery which have many drawbacks like repeated administration, fluctuation in blood concentration level etc. For the purpose of enhancement the bioavailability of furosemide, a dosage form with sustained release of furosemide was designed in this study.
    Sustained release tablets of furosemide were fabricated using xanthan gum(13.33 % to 66.67 %). Thepreparedtablets were evaluated for pre compression and post compression studies likeangle of repose, bulk density, tapped density, hardness, weight variation, fraibilty, drug content, in-vitro releaseof drugetc. among the five formulations A better controlled drug release (85 %) was obtained with the matrix tablet SX5 containingxanthan gum66.67%. Short-term stability studies of all formulations indicates that there were no significant changes in drug content and dissolution parameter values after 3 month storage at 40° ± 2°C/75 ± 5% RH.

  • 22 November 2013
    MORGELLONS DISEASE

    ABOUT AUTHORS:
    Jyotirmoyee Patnaik
    Kanak Manjari Institute of pharmaceutical Sciences.
    Rourkela, Orissa
    patnaik.jyotirmoyee@gmail.com

    ABSTRACT:
    Morgellons disease is a mysterious skin disorder that was first described more than 300 years ago. The disease is characterized by fiber-like strands extruding from the skin in conjunction with various dermatologic and neuropsychiatric symptoms Morgellons is a disease of skin lesions, where patients’ complain of itching with skin patches, discomfort and a feeling of something rolling under their skin, and finding fibers, whether single or in bunch on the surface of the skin, mostly on exposed areas such as the face, neck, chest, arms and other parts of the body. The signs and symptoms vary in different individuals.

  • 20 November 2013
    A REVIEW ON CHALCONES AND ITS IMPORTANCE

    About Authors:
    Vishwanadham Yerragunta*, T.Kumara swamy, D.Suman, V.Anusha, Prathima Patil, T. Samhitha
    Department of Pharmaceutical Chemistry,
    Vishnu Institute of Pharmaceutical Education and Research,
    Narsapur, Medak – 502313, A.P.
    Vishwanadham.y@gmail.com
    { DOWNLOAD AS PDF }

    Abstract:
    Chalcones are precursor compounds for flavonoids biosynthesis in plants, and they can also be synthesized in laboratory. Chalcones possess a broad spectrum of biological activities including antioxidative, antibacterial, antihelmintic, amoebicidal, antiulcer, antiviral, insecticidal, antiprotozoal, anticancer, cytotoxic and immunosuppressive. Changes in their structure have offered a high degree of diversity that has proven useful for the development of new medicinal agents having improved potency and lesser toxicity and good pharmacological actions. Chalcones became an object of continued interest in both academia and industry. Nowadays, several chalcones are used for treatment of viral disorders, cardiovascular diseases, parasitic infections, pain, gastritis, and stomach cancer, as well as like food additives and cosmetic formulation ingredients. However, much of the pharmacological potential of chalcones is still not utilized. The purpose of this review is to describe the recent efforts of scientists in pharmacological screening of synthetic chalcones, studying importance of chalcones, and synthesis of pharmacologically active chalcones and their biological activities.

  • 19 November 2013
    ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY

    About Authors:
    Jasinth. Danda*, Dr. P.Venkateswara Rao, P.Rama Bharathi, B.Madhavi, T.Swathi, Satya Lakshmi. Balla
    A.M Reddy Memorial College of Pharmacy,
    Department of Pharmaceutical Analysis
    Narasaraopet, ANU University, Guntur.
    Jasinthdanda18@gmail.com

  • 18 November 2013
    METHOD DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF PARACETAMOL AND EPERISONE HYDROCHLORIDE IN PHARMACEUTICAL DOSAGE FORMS

    About Authors:
    Venkata Anil Kumar Sistla*, Dr.P.Venkateshwara Rao, P.Rajavel
    Department of Pharmaceutical Analysis
    A.M.Reddy Memorial College of Pharmacy,
    Narasaraopeta - 522601,
    Guntur Dt, India.
    *anilkumar5831@gmail.com
    { DOWNLOAD AS PDF }

  • 17 November 2013
    SUCCESS STORIES OF ENOLATE FORM OF DRUGS

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    About Authors:
    Arvind Negi1*, Balraj Singh Gill2
    1Centre for Chemical and Pharmaceutical Sciences, Central University of Punjab, Bathinda- 151001
    2Centre for Biosciences, Central University of Punjab, Bathinda-151001
    *arvindnegi2301@gmail.com

    Abstract
    Stereochemistry of clinical agents play a key role in their success to become drugs. Tautomerism is a structural isomerism, playing a key role in the orientation of organic compounds and also found significant in distinctive base pairing in nucleic acids. Keto-enol form usually occurs and found prominently among different types of tautomers. The enol form ionizes in the physiological solution into enolate and alter the biological activity. So, how this enolate form brings modification in pharmacokinetics and pharmacodynamics of a drug is very important and quite interesting to know. As this form is ionic in nature so it increases the interaction with the concerning receptors, enzymes, ion channels or functional proteins. In this review we cover and compile success, role and the significance of the enolate form of clinical agents which succeed to become drugs!

  • 15 November 2013
    INDIAN PATENT AND INDIAN PATIENT, FRIEND OR RIVAL: A COMMUNICATION

    ABOUT AUTHORS:
    Prathima Patil*1, Tahseen Sameena1, S.P.Sethy, K.Shailaja1, P.Mishra2
    1Department Of Pharmaceutical Chemistry, Sushrut Institute of Pharmacy
    Taddanpally (V), Pulkal (M), Medak-502293.
    2Department Of Pharmacology, Malla Reddy College Of Pharmacy
    Maisimaguda, Dhulapalli, Secundrabad-14
    pratima.patil0@gmail.com

    ABSTRACT:
    Though patents are effective tools for promoting innovation and protecting intellectual property in the pharmaceutical sciences, there has been a growing concern that the current scenario of patient and patent is not vivid in developing countries like India. A lot of complications arise when a pharmaceutical firm applies for patent for their product in developing countries. Innovation in global health care needs patent protection as a safeguard, so patent is a must requires item for health care industries. We can say Patent as a fuel for innovation simultaneously it can burn the pocket of economically backward patients in developing countries. But this thing should not happen as both patent and patient needs each other. A friendly relationship should exist between them. In this context we have discussed about various aspect of patent and patient related issue and also about sensible solution for the issue.

  • 14 November 2013
    REVIEW ON ANTI AGING

    ABOUT AUTHOR:
    Sayoni Sengupta
    M.Pharm 1st Sem.
    Kanak Manjari Institute of Pharmaceutical Sciences
    Rourkela, Orissa
    bonirini@hotmail.com

    ABSTRACT
    Aging is the accumulation of changes in person overtime. Aging in humans refers to a multidimensional process of physical, physiological and social changes.
    Recent studies have revealed that certain medicinal herbs are effective in the intervention or prevention of aging and also in the eradication of age associated disorders. Herbs used in anti-aging programmes have medicinal properties which stimulate the vital organs in the body and restore their normal function. Many of them possess antioxidant properties.
    Ginseng derived from the Chinese term, belongs to the genus Panax, of the family Araliaceaeby the presence of ginsenoside.
    Recent studies explain the exotic role of Panax ginseng’s ginsenoside in promoting neurological health support and also state its beneficial effects in anti-aging and nerve related problems.

  • 14 November 2013
    ANAPHYLACTIC SHOCK: SHOCKING ERROR OF IMMUNE SYSTEM!

    About Author:
    Arvind Negi
    Centre for Chemical and Pharmaceutical Sciences
    Central University of Punjab, Bathinda-151001
    arvindnegi2301@gmail.com
    { DOWNLOAD AS PDF }

    Abstract
    Activation of immune response is developed in respect to some xenobiotic sensitization, which is supposed to prevent and protect the body from sufferings induced by these xenobiotic. But unfortunately sometime body behaves in a paradoxical manner which misguides the immune system and ultimately turned into a bizarre situation of immune function. One of such response is anaphylactic shock, which is quite fatal if untreated. This review brings insights into the molecular physiology of anaphylactic shock and how some people elicit allergic response to certain substances but not the other. This major catastrophe of the body holds an error of immune system whereas this commentary based review disclosed the synchronization of the unfortunate lessons of the immune system, which makes it a cruel to cause DEATH!

  • 13 November 2013
    ENHANCEMENT OF SOLUBILITY; AN OVERVIEW

    ABOUT AUTHORS:
    Ramesh Babu Pedada1*, Eukondalu Vanka1, Dr.A.M.S.Sudhakar Babu1, Prasanna kumar Desu1, P.Ramaa Bharathi1, P.Venkateawara.rao2
    1Department of Pharmaceutics, 2Department of Pharmaceutical  Analysis,
    A.M.Reddy Memorial College of pharmacy, Narasaraopet, Guntur (Dt), Andhra Pradesh, India.
    Rameshbabu.pedada@gmail.com
    { DOWNLOAD AS PDF }

    ABSTRACT:
    Enhancement of solubility, dissolution rate and bioavailability of drug is a very challenging task in drug development, nearly 40% of the new chemical entities currently being discovered are poorly water soluble drugs. Aqueous solubility of any therapeutically active substance is a key property as it governs dissolution, absorption and thus the in vivo efficacy. Orally administered drugs completely absorb only when they show fair solubility in gastric medium and such drugs shows good bioavailability. The solubility and dissolution properties of drugs play an important role in the process of formulation development. Problem of solubility is a major challenge for formulation scientist which can be solved by different technological approaches during the pharmaceutical product development work. The present review deals in detail about the solubilisation by surfactants, cosolvents, complexation for the improvement of solubility of poorly water soluble drugs.

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