Articles

19 May 2014

PROLOTHERAPY FOR ARTHRITIS- A REVIEW

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18 May 2014

INVESTIGATION OF HYDROGEL THICKENED MICROEMULSION FOR TOPICAL ADMINISTRATION OF MELOXICAM

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15 May 2014

FORMULATION AND EVALUATION OF SUSTAINED RELEASED PELLETS OF TRAMADOL HCl

ABOUT AUTHORS:
*S. Patel, M. Patel
Department of Pharma. Technology,
L.J.Institute of Pharmacy, Ahmedabad, Gujarat, India
shivanipatel090390@gmail.com

ABSTRACT:
The present research concerns the formulation and evaluation of sustained release pellets filled capsule of opioid analgesic, Tramadol HCl. Developmentof sustained release dosage form is to maintain therapeutic blood levels of the drug for extended period of time. Sustained release formulation provides uniform concentration at absorption site, maintains plasma concentration within a therapeutic range, reduces the dosage frequency and minimizes the side effects (nausea) associated with drug by avoiding dose dumping effect. Oral sustained release pellet formulations of Tramadol HCl were prepared using extrusion-spheronization technique. Pellets provide specific advantages of smoother plasma concentration profile and gradual absorption than tablet. Various polymers like Hydroxy propyl methyl cellulose (HPMC K100M), Carbopol, Xanthan gum, Ethyl cellulose and Eudragit RSPO were used to screen the best polymer combination through preliminary formulations. HPMC K100M and EC were screened and their concentrations were optimized using 3² full factorial design to achieve the aim of sustaining the drug release for 12 hours. Eudragit RSPO was used to coat the pellets. The prepared pellets were studied for different flow properties and drug release studies.

14 May 2014

A REVIEW ON ELAEOCARPUS SPHAERICUS (RUDRAKSHA)

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13 May 2014

HUNTINGTON’S DISEASE: AN UPDATE

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12 May 2014

CEREBRAL AGING AND NEUROLOGICAL DISORDERS

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9 May 2014

A POTENT TARGET FOR CANCER TREATMENT – TUMOR HYPOXIA NECROSIS: AN OVERVIEW

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8 May 2014

BRAIN AS A SANCTURIAN SITE IN DRUG DELIVERY APPROACHES TO IMPROVE BIOAVAILABILITY IN BRAIN

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ABOUT AUTHOR
Sagar Vishwanath Sonawane*
Dept. of Pharmaceutical Sciences and Technology,
Institute of Chemical Technology,
Matunga, Mumbai, Maharashtra, India.
*sssagarvs@gmail.com

ABSTRACT
Brain is the highly protected organ of the body by the sanctuary known as blood brain barrier (BBB). BBB comprises of tight junctions formed by the closed fenestration network of astrocytes, pericytes microglial cells and endothelial cells. Thus it is very difficult for drug molecules to cross BBB. Thus various approaches are discussed to overcome this barrier. Disruption of BBB was conventional invasive approach. The permeability of BBB increases in various diseases. This increased permeability of BBB is made use for drug trafficking. With advances in nanotechnology, various nanocarrier systems including Polymeric nanoparticles, Micelle, Dendrimer, Liposomes, Solid lipid nanoparticles, Nanostuctured lipid carriers, nanogels, etc. emerged as potential delivery systems.
Administration of inhibitors of p-glycoprotein with drug is another approach. Making lipophilic prodrugs of active drug substances can also be done.
Recently PEGylation of nanoparticles can be done to improve its half life in the body, known as the stealth technology. Further various receptor mediated processes are made use of for transport of nanocarrier across BBB. In this method the nanocarrier is attached to the targeting ligand thus making it receptor specific. The newer concept of molecular Trojan horses is also discussed. Finally the advantages of intranasal drug delivery are emphasized.

7 May 2014

DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF ILAPRAZOLE AND DOMPERIDONE IN PHARMACEUTICAL DOSAGE FORM

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5 May 2014

PHARMACOGNOSTIC AND PHYSICOCHEMICAL EVALUATION ON FRUITS OF GMELINA ARBOREA

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