ANTI-CANCER (NOVEL AGENTS): A REVIEW

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ABOUT AUTHORS:
V. Sravanthi*, Mayure vijay kumar, G.J.Finny, C.P.Meher
Department of pharmaceutical chemistry, Maheshwara College of Pharmacy
Isnapur chitkul ‘X’ road, Patancheru, Hyderabad-502307
*v.sravanthi27@gmail.com

ABSTRACT:
Cancer is a class of diseases characterized by out-of-control cell growth. Cancer cells damage the body by multiplying their cells uncontrollably to form masses of tissue named as tumor. Tumors cells can grow and interfere with the digestive, nervous, and circulatory systems, and they can release hormones that alter body function. Tumors that are severe to body are called cancerous tumors, and temporary cells that are affected to body are not harmful and called as benign tumors. Nearly 100’s of cancers are known to be effecting the humans. According to this concern the presented review outlines the novel anticancer agents how they are useful, their mechanism, and chemistry has briefly discussed in this article, the main aim of these review is to evaluate the complete novel anticancer drugs under single review paper.

REFERENCE ID: PHARMATUTOR-ART-2222

PharmaTutor (ISSN: 2347 - 7881)

Volume 2, Issue 8

Received On: 05/06/2014; Accepted On: 09/06/2014; Published On: 01/08/2014

How to cite this article: V Sravanthi, VK Mayure, GJ Finny, CP Meher; Anti-Cancer (Novel Agents): A Review; PharmaTutor; 2014; 2(8); 119-153

INTRODUCTION:
Cancer is the largest cause of death in the developed world. Cancer affects 1 in 3 people and is responsible for 25% of all deaths. Here are more than 100 different types of cancer. For example, lung cancer starts in the lung, and breast cancer starts in the breast. The spread of cancer from one part of the body to another is called metastasis. 

PERCENTAGE

CAUSE

30%

Smoking (lung, mouth, pharynx, larynx, esophagusetc;)

15%

Viruses (papillomavirusetc;)

Six characteristics of malignancies have been proposed:
· self-sufficiency in growth signalling
· insensitivity to anti-growth signals
· evasion of apoptosis
· enabling of a limitless replicative potential
· induction and sustainment of angiogenesis
· activation of metastasis and invasion of tissue.1

 

The progression from normal cells to cells that can form a discernible mass to outright cancer involves multiple steps known as malignant progression2

SCHEME OF CANCER CAUSES3:

ADVANCES IN CANCER CHEMOTHERAPY3:

SURGERY: BEFORE 1955
RADIOTHERAPY: 1955-1965
CHEMOTHERAPY: AFTER 1965
IMMUNOTHERAPY AND GENE THERAPY

CELLULAR PATHWAY TO MALIGNANCE4:

GENERAL MECHANISM OF ANTICANCER DRUGS5:



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good job , well done

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