Articles

11 September 2015

REGULATORY REQUIREMENTS AND REGISTRATION PROCESS OF GENERIC DRUGS IN CHINA

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9 September 2015

FORMULATION AND EVALUATION OF GASTRORETENTIVE HYDROCHLOROTHIAZIDE FLOATING MICROSPHERES: STATISTICAL ANALYSIS

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7 September 2015

ANTIBACTERIAL, CYTOTOXIC AND ANTIOXIDANT ACTIVITIES OF N-HEXANE, CHLOROFORM AND ETHYL ACETATE EXTRACTS OF TRICHOSANTHES CUCUMERINA LEAVES

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4 September 2015

DIAGNOSIS OF GRANULAR CELL TUMOUR OF THE UPPER LIP USING POLYMER HRP DETECTION SYSTEM

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ABOUT AUTHORS:
¹Neeraj Kumar Lohani*, ²Prakash Singh Nainwal
¹Institute of Biomedical Education & Research, Mangalayatan University, Aligarh- Uttar Pradesh, India,
²Govt. medical College Haldwani, Nainital Uttrakhand, India
*neerajlohani06@gmail.com

ABSTRACT:
Oral granular cell tumour is a rare soft tissue tumour ofcan develop on any skin or mucosal surface. Granular cell tumors can affect all parts of the body; however, the head and neck areas are affected 45% to 65% of the time. Of the head and neck cases 70% of lesions are located intraorally (tongue, oral mucosa, hard palate). The next most common location that lesions are found in the head and neck area is the larynx(10%).^[1] In patients 30% of cases have been reported to occur in the lip, but this presentation in adults is extremely rare. The present study is concerned a case of oral granular cell tumour in a 60 year-old female, located in the upper lip. Histopathological examination revealed granular cells which stained positively for S-100 protein; a finding supportive of a neural origin. A history of trauma was elicited in this case, and the lesion was treated with surgical excision.

2 September 2015

EVLUATION OF EFFECTS OF COMMIPHORA WIGHTII IN DEHYDROEPIANDROSTERONE (DHEA) INDUCED POLYCYSTIC OVARY SYNDROME (PCOS) IN RATS

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31 August 2015

ANTIBACTERIAL, ANTIOXIDANT AND CYTOTOXIC ACTIVITIES OF TREWIA NUDIFLORA

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27 August 2015

A REVIEW AND APPLICATION OF CRYOPROTECTANT: THE SCIENCE OF CRYONICS

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25 August 2015

GABAPENTIN: A NEW BROAD SPECTRUM ANTIEPILEPTIC DRUG

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ABOUT AUTHORS:
Firake Bhushan M.¹, Pandagale Sagar J.², Firke Sandip D.³, Palshikar Gautam S.⁴
¹Department of Pharmaceutical Chemistry, JSPM’s Jayawantrao Sawant College of Pharmacy and Research, Hadapsar, Pune
²Department of Pharmaceutical Analysis, JSPM’s Jayawantrao Sawant College of Pharmacy and Research, Hadapsar, Pune
³Department of Pharmaceutical Chemistry, SES’s R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur
⁴Department of Pharmacognosy, JSPM’s Jayawantrao Sawant College of Pharmacy and Research, Hadapsar, Pune
bmf.jscopr@gmail.com

ABSTRACT:
Epilepsy is one of the most serious disorders of the brain, affecting about 50 million people worldwide. Epilepsy leads to multiple interacting medical, psychological, economic and social consequences. Successful seizure control is very important in decreasing the psychosocial and economic costs of epilepsy. Yet, most therapies didn’t completely improve patients for numerous reasons. The most effective antiepileptic drugs (AEDs) include phenytoin, carbamazepine, valproic acid, phenobarbital, and primidone. Of the older AEDs, carbamazepine and valproic acid together bring a threat of hepatic toxicity and have been associated with fetal anomalies. Carbamazepine and phenytoin aggravate hypersensitivity reactions in a significant number of patients, and phenytoin is associated with chronic adverse events (AEs). Phenytoin, carbamazepine, phenobarbital, and primidone are hepatic enzyme inducers. Valproic acid, on the contrary, is a powerful hepatic inhibitor.

The newer agents have fewer drug interactions and slight, if at all, effect on the CYP₄₅₀ enzyme system and other metabolic pathways. One of these new agents was gabapentin (GBP). GBP, the new antiepileptic drug (AED) has a broad spectrum of anti-seizure effects, less adverse effects and less drug interaction. GBP has since achieved international acknowledgment, not for its antiepileptic properties, but also its effectiveness in the managing of acute and chronic pain syndromes, especially neuropathic pain. It is prescribed as an add-on medication for the treatment of patients aged >12 years with partial and secondary generalized tonic-clonic seizures and for children aged 3 to 12 years with partial seizures. It has been used for monotherapy in adults in 38 countries. Gabapentin is regarded as safe and tolerable with a promising pharmacokinetic profile and an extensive therapeutic index.

The present article reviews the available information that dealing with the long-standing efficiency and safety of gabapentin in the treatment of patients with epilepsy.

20 August 2015

DATA INTEGRITY NON-COMPLIANCES – THE GOOD, BAD AND UGLY

ABOUT AUTHORS
Krishnendu Singha
Manager – Quality Assurance
[The author is a Quality Assurance professional of a leading MNC]
Krish_singha2007@yahoo.co.in