Articles

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ABOUT AUHTOR
*R SHARMA, S SARMA
Assam Down Town University, Guwahati, Assam, India
*Rupsmita2010@gmail.com

ABSTRACT
Objectives: The aim of the present study was to estimate flavonoid and phenolic content, and to evaluate invitro antioxidant activity of an aqueous extract of Alpinia nigra and Allium tuberosum.
Methods: The air dried stem of A. nigra and leaves of A. tuberosum was ground to powder and extracted with water and 95% of ethanol. The extract was screened for phytochemicals, total phenolic content (TPC) and total flavonoid content (TFC) with its potential antioxidant activities using hydrogen peroxide-scavenging assay.
Results: Phytochemical test shows that extract contains variety of phytochemicals among which there is a high level of total phenol and flavonoids. The total phenolic content (TPC) of A. nigra and A. tuberosum was 0.450±0.0740 and 1.663±0.296; respectively. The total flavonoid content (TFC) of A. nigra and A. tuberosum was 0.322±0.077 and 0.978±0.119, respectively. The plants possessed potent antioxidant activity when compared with the reference compound ascorbic acid (vitamin C).
Conclusions: A. nigra and A. tuberosum may be useful for the preparation of neutraceuticals as potent antioxidant to treat various human diseases and their complications.

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ABOUT AUHTOR
Deepak Chowrasia* Dr. Nisha Sharma
University Institute of Pharmacy, CSJM University,
Kanpur, U.P.-208024, India
*chowrasia.deepak@gmail.com

ABSTRACT
The article describes here some of the aspects of scattering of light and its applicability in Nephelo-turbidimetric analysis.

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Nitisha Bhandari*, Akanksha Bhandari
Shri Guru Ram Rai Institute of Technology and Science, Patel Nagar,
Dehradun 2Graphic Era University, Dehradun, India
*nitishabhandari89@gmail.com

ABSTRACT
Interactions of proteins could be resulted from homodimerisation or heterodimerisation. But these are quite specific and always selective in nature and act onlyon particular set of class of proteins, which provide substantial target behaviour to a drug designer. Here in this paper, provided a commentary based review compiling the short notes information provided on protein proteins interactions, by “Catherine Royer”

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ABOUT AUHTOR
HardikRana*, BhargavVaghasiya, MansiDholakia
Department of Pharmaceutics,
Anand Pharmacy College, Anand, 388 001, Gujarat, India.
*hardikrana1439@gmail.com

ABSTRACT
The objective of present study was to enhance the solubility of poorly soluble drug Ibuprofen using spherical crystallization technique.The potential agglomerates were prepared by addition of different concentrationof polymer selected on the basis of Phase solubility study. Spherical agglomerates were prepared using diethyl ether as bridging liquid by neutralizing technique, spherical agglomeration technique, Quasi emulsion solvent diffusion technique. Spherical agglomerates were evaluated for morphology, production yield, drug content, particle size and dissolution behaviour compared with pure drug.The result of phase solubility studies revealed that there is enhancement of solubility by PEG 4000. Rod shaped crystals of pure drug converted to spherical was confirmed by optical microscopy. The dissolution of agglomerates of optimum batch exhibited 88.24% release compare to 47.18% of pure drug within 60 minute. This study demonstrated that spherical crystallization technique can be consider as a suitable alteration of granulation. Ibuprofen spherical agglomerates can be prepared with PEG 4000. It exhibited excellent physicochemical, solubility, dissolution rate in comparison with pure drug. Among other spherical crystallization technique, QESD proved to be excellent techniquefor enhancement of solubility and dissolution.

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ABOUT AUHTOR
Manish Patil*¹, Harsha D Jani¹, Suleman S Khoja², Narmin A Pirani³, Shamim S Khoja^3
1Department of Quality Assurance,
Shivam Pharmaceutical Studies and Research Centre, Anand
Gujarat, India.
²Resource person in pharmaceutical quality assurance and Audit Compliance, Vapi
³Registered Pharmacist, Gujarat, India
*manishpatil3194@gmail.com

ABSTRACT
This review article presents the pharmacology of combined Metformin hydrochloride and Teneligliptin hydrobromide hydrate is effective on type 2 Diabetes Mellitus. Metformin is an antihyperglycemic agent which improves glucose tolerance in patients with type 2 diabetes, lowering both basal and postprandial plasma glucose. Teneligliptin, a third generation Dipeptidyl Peptidase-4 (DPP-4) inhibitor exhibits unique “J shaped” structure with “anchor-lock domain” mechanism which provides potent & long duration of action. The addition of teneligliptin once daily to Metformin was effective and generally well tolerated in Korean patients with type 2 diabetes. The mechanism of Metformin hydrochloride and teneligliptin hydrobromide hydrate is quite different. The main objective of this review article is to provide pharmacological and Analytical information of combination of Metformin hydrochloride and Teneligliptin hydrobromide hydrate to researcher in development of combined dosage form.

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ABOUT AUTHOR
Komal Saini
Department of Pharmaceutics,
University Institute of Pharmaceutical Sciences,
Panjab University,
Chandigarh, India.
komalsainiks@gmail.com

Nanomaterials and nanotechnology play pivotal roles in emerging science and technology, and are poised to have a broad and fundamental impact on the global economy.

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Narendra M.Petha, J.G.Patil,Mr J.G.Chandorkar
Indofil Industries Ltd, Gujarat
jchandorkar-icc@modi.com

ABSTRCT 
Gatifloxacin is a antibacterial agent, Rapid, sensitive and selective analytical method is essential for monitoring the different reactions steps involved in process development of Gatifloxacin. A simple isocratic reverse phase High Performance Liquid Chromatographic [HPLC] method was developed for simultaneous separation of different intermediates and other impurities. The method was utilized successfully in analyzing the reaction streams, related substances in final product and for the assay in drug.

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G.Swapna
Department of pharmaceutical Analysis & Quality Assurance,
Nirmala college of pharmacy, Guntur,
AP, India
swapna.goday.gs@gmail.com

ABSTRACT
To make drugs serve their purpose various chemical and instrumental methods were developed and regular intervals which are involved in the estimation of drugs. A photoelectric flame photometer is a device used in inorganic chemical analysis to determine the concentration of certain metal ions, among them sodium, potassium, lithium, and calcium. Group 1 and Group 2 metals are quite sensitive to Flame Photometry due to their low excitation energies ^[1].These pharmaceuticals would serve their intent only if they are free from impurities and are administered at appropriate amounts ^[2] . These pharmaceuticals develop  impurities at various stages of their development, transportation and storage which makes the pharmaceuticals risky to be administered thus they may be detected and quantified. For this analytical instrumentation and methods play important role. This review highlights a variety of analytical techniques for analysis of inorganic elements. Analytical techniques for analysis of inorganic elements. The most commonly used techniques for the determination of inorganic elements is atomic spectroscopy the different branches of atomic absorption spectroscopy are(1) flame photometry or flame atomic emission spectrometry. (2) atomic absorption spectrophotometer, (aas). (3) inductively coupled plasma-atomic emission spectrometry (icp-aes).(4)  uv - visible    spectrophotometer.

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ABOUT AUHTORS
SRIJITA DUTTA
DEPARTMENT OF PHARMACEUTICAL TECHNOLOGY
BENGAL SCHOOL OF TECHNOLOGY
Hooghly,  West Bengal
srijitadutta1991@gmal.com

ABSTRACT: Biotechnology is a manipulation technology of living organisms and organic material to serve Human Needs. To make a better world some basic need (sufficient food, healthy life, eco-friendly/anti-polluted environment and employment) of the people should be fulfill. For that biotechnology can be used to struggle with these issues