Articles

FORMULATION AND EVALUATION OF FELODIPINE TABLETS USING DIFFERENT CARRIERS AND DIFFERENT METHODS OF PREPARATION FOR ENHANCEMENT OF SOLUBILITY

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ABOUT AUTHORS
P.Mounika*, Sanjit, Abhishek pandey
Gautham College of Pharmacy
Hebbal, Bengaluru, Karnataka

ABSTRACT:
All active pharmaceutical ingredients are having good therapeutic activity and show poor oral bioavailability , because of poor solubility .The present study is to investigate to improve the solubility of Felodipine using different carriers and different methods of preparation of techniques to identify that which carrier and suitable method of preparation. All formulation are evaluated for hardness, friability, drug content uniformity, and in vitro dissolution studies. Among all the formulations three formulation shows good drug release and the formulation with direct compression method shows good drug release compared to other formulation among all the formulation Polyvinylpyrrolidone (PVP) with direct compression is considered as ideal formulation from the study.

A REVIEW ON ANALGESIC HERBALS

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Nilima A. Thombre*, Swati Madhukar Gaikwad, Kanchan Subhash Chaudhari
MET’S Institute of Pharmacy, Adgaon, Nashik, Maharashtra, India

ABSTRACT:
Analgesics are the substances which are used in pain, without losing consciousness. The word analgesic derives from Greek an- ("without") and algos ("pain"). Analgesic drugs act in various form on the central nervous systems and peripheral nervous system. Various sources of analgesic drugs synthetic analgesic and natural analgesic, natural analgesics like opoid analgesics, Aloevera Barbedensis, Glycyrrhiza glabra, Zingiber Officinale, Eugenia caryophyllata, Cinnamomum camphora, Matricaria pubescens etc. This review gives information about different analgesic obtained from natural sources.

PATIENT RELATIONSHIP MANAGEMENT : PATIENT CARE WITH CRM APPROACH

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ABOUT AUTHOR
AK Mohiuddin
Department of Pharmacy, World University of Bangladesh,
Dhanmondi, Dhaka, Bangladesh

ABSTRACT
In the business world, customer relationship management is utilized to hold customer reliability so as to expand income. Healthcare associations can fabricate a similar sort of relationship with patients, and it can likewise offer progressively unmistakable advantages. The principal advantage is by utilizing a similar hospital a patient's treatment history ought to be moderately outstanding by the association. Intermittently, extraordinary hospitals utilize distinctive patient data frameworks which are not constantly perfect with one another. On the off chance that a patient continues changing the hospital, his or her medical record can be dissipated around different destinations. In a perfect world, if the patient is treated by a similar doctor in each visit, that doctor will get progressively comfortable with the patient, which could enhance treatment. The most unmistakable advantage, be that as it may, is time. In the event that the patient goes to a similar doctor inevitably, there is no requirement for long registration toward the start of each visit. In spite of the fact that a developing collection of proof backings the utilization of cell phone short message service (SMS) for increasing physical movement, sustenance, and smoking suspension, past investigations were constrained by an attention on center to upper pay populaces, and have not focused on transcendently country networks outside the healthcare conveyance framework. Hospital websites are considered as a fitting framework for trading data and building up correspondence between patients, hospitals, and medical staff. Website character, website contact intelligence, shopping accommodation, just as consideration and service are the variables to the extent the patient relationship management is concerned. In healthcare situations, patients are considered as the primary customers; in this way, the term Patient Relationship Management (PRM) is utilized in these unique situations. PRM permits healthcare focuses to have a superior understanding into the requirements of patients while giving them better consideration. Thusly, PRM gives a chance to utilize information and data to comprehend customers and to make an incentive with them. The requirement for PRM developed when associations comprehended that it was less exorbitant to keep their present customers, while pulling in another customer would be more-expensive for an association than keeping their present customers.

COMMUNITY LIAISON PHARMACISTS IN HOME CARE

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ABOUT AUTHOR
AK Mohiuddin
Department of Pharmacy,
World University of Bangladesh,
Dhanmondi, Dhaka, Bangladesh

ABSTRACT
The term “Home-based care” or simply home care may be defined as a wide array of different types of care provided in the home by a wide range of parties. The continuum of different types of home-based care delivered in the home varies in terms of different dimensions, including acuity, type of care provided, and degree of physician involvement. Home-based care includes both formal and informal personal care services, Medicare skilled home health, physician house calls, and even “hospital-at-home” services. Medication-related issues are basic among home care patients who take numerous medications and have complex medical chronicles and medical issues. The objectives of home social insurance administrations are to assist people with improving capacity and live with more prominent freedom; to advance the customer's ideal dimension of prosperity; and to help the patient to stay at home, maintaining a strategic distance from hospitalization or admission to long-term care foundations. Home care is an arrangement of care given by talented experts to patients in their homes under the bearing of a doctor. Home medicinal services administrations incorporate nursing care; physical, word related, and discourse language treatment; and medical social administrations. Doctors may allude patients for home medicinal services administrations, or the administrations might be asked for by relatives or patients. The scope of home human services benefits a patient can get at home is boundless. Contingent upon the individual patient's circumstance, care can extend from nursing care to specific medical administrations, for example, laboratory workups. Basic analyses among home medicinal services patients incorporate circulatory disease, coronary illness, damage and harming, musculoskeletal and connective tissue disease and respiratory disease.

ESTIMATION OF LACIDIPINE IN BULK AND PHARMACEUTICAL DOSAGE FORM BY ZERO ORDER, AND FIRST ORDER DERIVATIVE UV SPECTROPHOTOMETRIC METHODS

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DANDU GIRIJA, *AKKIMI PADMA, A.TIRUPATHIREDDY, BASU VENKATESWARA REDDY
Sankar Reddy Institute of Pharmaceutical sciences, Salakalveedu, Bestavaripeta, Prakasam, Andha pradesh, India.

ABSTRACT
The present research work was broadly focused on the estimation of in Lacidipine in bulk and pharmaceutical dosage form by using two UV spectrophotometric methods like Zero order spectroscopy (Method-1), and first order derivative spectroscopy (Method-2). The solvent employed for the two methods was methanol and absorption maximum was found to be 284nm, and 277nm respectively. The developed methods showed linearity sin the range between 20-100µg/ml. The correlation co-efficient was ≥ 0.999. The precision (%RSD) for all the two methods was found to be ≤2. The accuracy was performed by spiking standard drug at 50,100 and 150% of the test concentration and the values obtained were within the limits. The assay for the formulation was found to be within limits. All the results were satisfactory the developed methods were linear, accurate, reproducible and robust. 

GLANZMANN’S THROMBASTHENIA : A RARE BLEEDING DISORDER

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SRI HARSHA AYYAGARI.*HARI PRIYA MULLAMURI, SOWMYA  BYREDDY,   DURGA PRASAD T. S.
Sri Padmavathi School of pharmacy, Jawaharlal Nehru Technological University, Anantapuram, Andhra Pradesh, India.

ABSTRACT
Glanzmann's Thrombasthenia (GT) is a rare, autosomal recessive bleeding disorder characterized by prolonged bleeding time and impairment in aggregation of platelets and impairment in clot retraction. The physiological defect includes impairment of glycoprotein receptor’s (GPIIb/IIIa complex) present on platelet membrane which mediates platelet aggregation through fibrinogen binding. Purpose of this study is to get  all of us know about this rare condition. A 16-year old female patient presented with repeated episodes of menstrual bleeding since 4years. She was a k/c/o Glanzmann's thrombasthenia. She was treated with antifibrinolytics, IV fluids and then discharged. Early diagnosis and proper supportive care are the measures for prognosis of Glanzmann’s thrombasthenia.

DRUG UTILIZATION OF ANTI HYPERTENSIVES IN CKD PATIENTS: A RANDOMIZED PROSPECTIVE STUDY AT A TERTIARY CARE TEACHING HOSPITAL

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ABOUT AUTHORS
ASHIKA RANJANI. M*, SAHITHI GOUD. B, AMATUL WADOOD SUMAYYA, SYEDA NABILA FIRDOUS, AMATUL ALI SAMEERA
Dept. of Pharmacy Practice
Sree Dattha Institute of Pharmacy, Jawaharlal Nehru Technological University (Hyderabad)
Sheriguda (V), Ibrahimpatnam (M), Ranga Reddy (Dist), Telangana, India

ABSTRACT
AIMS AND OBJECTIVES: Our aim was to evaluate the clinical use of Antihypertensive drugs in patients with chronic Kidney disease at a tertiary care teaching hospital.

METHOD: An observational, prospective cohort study was conducted at a tertiary care teaching hospital in Hyderabad, T.S, India. A total of 184 patients from the inpatient department of nephrology Department at  Gleneagles Global Hospitals, Bairamalguda, LB Nagar, Hyderabad. All information significant to the study was collected from the case records and discussions conducted with the in-patients and bystanders during ward rounds, with the support of a physician, which were analyzed by SPSS software. Moreover, daily follow-ups were conducted to assemble data on amendment in therapy, add-on therapy, and clinical improvement.

RESULTS: The Mean Age was 59.29 years and the standard deviation was 1.116 of the population, 60% were smokers and 40% were alcoholics. The most commonly used Class of anti-hypertensive drugs are Calcium channel blockers with percentage of 64.13%, Diuretics with percentage of 57.60%, β blockers with percentage of 43.47%. Whereas most commonly used Calcium channel blockers are Amlodipine with percentage of 52%, and Cilindipine with percentage of 9.10%.Diuretics are are Furosemide with percentage of 36.90% and Toresemide 11.40%. Most commonly used Adenergic Antagonist are in β Blockers are Metoprolol with percentage of 31.50%, In α blockers are prazosin with percentage of 26%, In α+β blocker are Carvedilol with percentage of 8.60%. Most commonly used ARB’s are Telmisartan with percentage of 6.50%, and ACE’s are Ramipril with percentage of 1%. Most commonly used central sympatholytics are Clonidine with percentage of 18.40%, Vasodilators are Minoxidil with percentage of 1%. Medication adherence have been done, In which patients with High Adherence are with percentage of 16.21%, Medium Adherence are with percentage of 45.94%, Low Adherence are with percentage of 37%. This is done by Morisky medication adherence scale 8.

CONCLUSION: We have concluded that the CCB’s, diuretics and β-blockers are the most commonly used anti-hypertensive classes in hypertensive patients with CKD. Use of anti-hypertensives in CKD patients does not deviate from the guidelines laid down by NKF KDOQI guidelines. The patients should be educated about the rational use of drugs to decrease medication adherence.

IN SILICO PHARMACOKINETICS AND MOLECULAR DOCKING STUDIES OF LEAD COMPOUNDS DERIVED FROM DIOSPYROS MESPILIFORMIS

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Aliyu Hamidu Ahmed1, Yusuf Ibrahim Alkali2
1Department of Pharmacognosy and Ethno pharmacy, Faculty of Pharmaceutical Sciences
Usmanu Danfodiyo University, Sokoto- Nigeria
2Department of Pharmacology and Toxicology, Usmanu Danfodiyo University, Sokoto- Nigeria.

ABSTRACT
Pharmacokinetics and toxicity profile along with efficacy are the major determinants for successful drug development. This study was carried out to determine the pharmacokinetic profile, potential biological activities and toxicity of diospyrin, lupeol and plumbagin using in silico approaches. The Swiss ADME tool was used to calculate the molecular properties of the ligands based on Lipinski’s rule of five (5).All ligands in the present study satisfied the rule. Using the Swiss ADME tool, the pharmacokinetic profile of the compounds was evaluated. Protox-II server was used to predict the organ toxicities and toxicological end points of the ligands and their LD50. Plumbagin is found to have both mutagenicity and carcinogenicity. Lupeol and diospyrin are reported to be immunotoxic. Lupeol has LD50 of 2000mg/kg. Diospyrin and plumbagin have 16mg/kg. Swiss target prediction server was used to identify the various potential target. The target prediction suggests that plumbagin and lupeol have high preference for Microtubule-associated protein tau (MAPT). The best target for diospyrin was Aurora kinase A. Molecular docking study was conducted using AutoDock vina in The Python Prescription (PyRx) 0.8 virtual screening tool.  Plumbagin and lupeol were docked against Microtubule associated protein tau. The dockings scores based on binding energy were; plumbagin -33.8 (kcal/mole) and lupeol -44.7 (kcal/mole). Diospyrin showed a binding energy of -10.7 (kcal/mole) against Aurora A kinase. Results in this study suggest that diospyrin may serve as an important aurora kinase inhibitor while lupeol and plumbagin may be useful in treatment of Alzheimer’s disease.

CASE ON PITUITARY MACROADENOMA

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ABOUT AUTHORS
Asha K Rajan, Vedha pal Jeyamani.S*, Kaviya U, Merlin Joan , Lavanya. R
Department of Pharmacy Practice,
Jaya College of Paramedical Sciences,
College of Pharmacy, Thiruninravur,
Chennai, Tamil Nadu, India.

ABSTRACT: 
Pituitary adenomas are slowly progressive and usually benign type of tumors which may induce a poor quality of life of patients due to progressive loss of vision over time by compression of optic nerves, cavernous sinus, optic chiasm. Its therapy generally involves differential diagnosis with an MRI of Brain and surgical option with radiation therapy. Here with we present a case of 48 year old women who had undergone microscopic transnasal transphenorbital excision of tumor two years ago of pituitary macroadenoma. She was not on any chemotherapy which led to a recurrence of her tumor. Presently her MRI scan and histopathologic reports confirms the diagnosis of Pituitary macroadenoma which was effectively treated surgically and put up on Dihydroartemisnin, a derivative of Artemether which has similar cytotoxic properties as that of artemether.

A REVIEW “THREE DIMENSIONAL (3D) DRUG PRINTING : A REVOLUTION IN PHARMACEUTICAL SCIENCE”

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ABOUT AUTHORS
Ubaid Tariq1, MohdMazhar*2
Delhi Pharmaceutical Science and Research University,
M.B. Road, Saket , New Delhi, 110017, India

ABSTRACT:
Three-dimensional (3D) printing is a manufacturing method in which objects are made by fusing or depositing materials in successive layers laid down under computer control. These objects can be of almost any shape or geometry and are produced from a 3D model as defined in a computer-aided design (CAD). Since the inception of 3D printing in 1984 it has evolved immensely and has been used in many fields including medicine, architecture and more recently in pharmaceutical manufacturing. From lab grown organs to drug delivery devices, 3D printing is advancing rapidly and in future course of time it is going to transform and change the way we live and work.

3D printing in pharmaceuticals has been used to produce many novel dosage forms like microcapsules, Complex Drug-Release Profiles, nano-suspensions, and multilayered drug delivery devices. From industrial point of view it also offers important advantages like, cost-effectiveness, increased productivity, democratization of design and manufacturing, and enhanced collaboration.Keeping in view the recent approval given by USFDA to the first 3D printed antiepileptic drug the focus has now shifted to the personalized medicine as it offers an important benefit to patients who need medications that have narrow therapeutic indices or a higher predilection to be influenced by genetic polymorphisms. 3D printer is now seen as a valuable, efficient and economical tool to manufacture individualized medications, tailored to specific patients based on their needs and thereby change the future of pharmacy practice in general and pharmaceutical care in particular.

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