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ABOUT AUTHORS
SANDHIYA.V*¹, KAVITHA.C^2
1 Department of Pharmaceutics, C.L.Baid metha College Of Pharmacy, Thoraipakkam, Chennai, India
² Department of Pharmacognosy, C.L.Baid Metha College Of Pharmacy, Thoraipakkam, Chennai, India
*sandhiyavaithi@gmail.com

ABSTRACT
The leaves of Azima tetracantha belongs to salvadoraceae family, commonly known as “mulluchangu” in tamil, it is a best known medicinal plant from ancient period. The plant has reported for many pharmacological action such as antifungal, antibacterial, hepatoprotective, anti inflammatory, anti ulcer, anti arthritic, hypolipidemia etc. The present study was investigated about the characteristics, quantitative estimation and antifungal activity of Azima tetracantha leave in different solvents extract (hexane, chloroform, ethanol, ethyl acetate and water) successfully. In quantitative estimation the leaves of Azima tetracantha shows 48.4 % yield of carbohydrate in water extract, 21%  yield of phenol in ethanol extract and 24%  in ethyl acetate extract and 19% yield of tannin in ethanol extract. In antifungal activity of Azima tetracantha leave two standard drugs are used such as clotrimazole (10 mcg/m1 as standard-1) and ketaconazole (10 mcg/ml as standard -2). The antifungal activity was studied for all extracts in a concentration of 100 mcg/ml, 200 mcg/ml and 400mcg/ml against Candida albicans and Aspergillus niger. The Ethanol extract of a leave of Azima tetracantha in increasing concentration shows prominent activity against Candida albicans compared to other extract. The Hexane, Chloroform and Water extracts of a leave of Azima tetracantha shows moderate activity against Candida albicans compared to ethyl acetate extract. The Ethyl acetate extract shows slight activity against Candida albican scompare to other extracts. There was no activity was observed for various extracts of Azima tetacantha against Aspergillus niger.

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V.T. Iswariya*, A.Hariomprakash Rao, K. Sri Jahnavi, A.Sravanthi, P. Deepa, K. Samatha
M.R.R. College of Pharmacy,
Nadergul, Andhra Pradesh, India
*iswariyapharma@gmail.com

ABSTRACT
The technique of Solid dispersion and sublimation techniques are a promising method towards enhancing the dissolution of poorly soluble drugs. The main objective of Resperidone mouth dissolving tablets is to enhance the solubility. Several formulations of solid dispersion and sublimating tablets were prepared by using different ratio of drug sublimating agent (Camphor) and carriers (PEG 4000, Polaxomer, Mannitol). The prepared Solid dispersion and sublimating tablets were evaluated for their flow properties such as bulk density, tapped density, angle of repose, Carr’s index and Hausner’s ratio. The interaction between drug and excipients were studied by FTIR. In vitro dissolution profiles of the solid dispersion and sublimation formulations were studied and compared between sublimation and solid dispersion formulation. Among all formulations SD2 formulation was shown maximum drug release in less time.

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Sadanand Maurya*¹, Devendra Goyal², Chandan Verma^1
1 Department of Quality Assurance in Macleods Pharmaceutical Limited
² Department of Production in Macleods Pharmaceutical Limited
*sadanandmpharma@gmail.com

ABSTRACT
Manufacturing of Pharmaceutical products shall demonstrate a control to reproduce consistently the desired quality of product, wherein the control of cross-contamination plays an important role. An effective cleaning shall be in place to provide documented evidence that the cleaning methods employed within a facility consistently controls potential carryover of product (including intermediates and impurities), cleaning agents and extraneous material into subsequent product to a level which is below predetermined levels. Pharmaceutical manufacturers must validate their cleaning process to ensure compliance with cGMP regulations. So it is necessary to validate the cleaning procedures to ensure safety, efficacy, quality of the subsequent batches of drug product and regulatory requirements in Pharmaceutical product manufacture. In this article cleaning validation and cleaning validation program discussed in brief.

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G.Hema Latha¹*, MD.Sultan Ali², C.Vijaya lakshmi  R.Kiran kumar¹, C.V.H.Hemavathy^1
1 Kottam Institute of Pharmacy, Erravally X Roads, Mahaboob Nagar, Telangana
² Safa College of Pharmacy, Kurnool, A.P
*hemarayudu19@gmail.com

ABSTRACT
Protective effect of ziziphus jujuba  in cerebral ischemia reperfusion injury in albino rats. The main aim of the present work is to evaluate the Protective effect of Ziziphus jujuba  in cerebral ischemia reperfusion injury in albino rats. Objectives are to test the  Preliminary phytochemical screening of Aqueous & Petroleum ether extracts of “Ziziphus Jujuba”. Group 1: Control group; Group 2: Animals treated with lead 0.1 ml/100 g body weight i.p; Group 3: Animals treated with Petroleum ether extract of Ziziphus Jujuba 250mg/kg; Group 4: Animals treated with Petroleum ether extract of Ziziphus Jujuba 500mg/kg.All the groups were subjected to pre-treatment for a period of 7 days except Control group. To compare the changes in Quantification of infract size in normal and treated groups. To compare the changes in SGOT levels in Control and treated groups. The protective effect of the aqueous extract ,petroleum ether extract of Ziziphus Jujuba may be due to the presence of flavonoids, saponins, triterpenoids and tannins. There was a dose dependent increase in cerebral protection in terms of reduction of infarct size of brain tissue and SGOT levels in serum. Furthermore investigation is needed to find out the particular constituent which is responsible this protective activity.

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S. Ashutosh Kumar*, Manidipa Debnath,Vaddi Pavan Krishna Kumar
Department of Pharmaceutical Analysis and Quality Assurance,
A.K.R.G College of Pharmacy,
Nallajerla, West Godavari, A.P
* ashu.mpharm2007@gmail.com

ABSTRACT
Purpose: A simple, precise, accurate, rapid and economical reverse phase high-pressure liquid chromatographic method has been developed as per ICH norms for the estimation of Naproxen from pharmaceutical formulation.
Methods: The method was carried out on a Kromosil-C₁₈ ODS column (150 mm X 4.6 mm; 5 µ) with a mobile phase consists of ammonium acetate buffer (adjusted to pH 4.0 with 1 % Triethyl amine): methanol (40:60 v/v) and filtered through a 0.45 µ cellulose nitrate filters. The flow rate was maintained in isocratic mode at 1.0 mL/min. The detection was carried out at 210 nm. The run time was 7.0 min.
Results: The retention time was 3.063 min for Naproxen. The developed method was validated in terms of accuracy, precision, linearity, limit of detection, limit of quantification and solution stability.
Conclusion: The proposed method was adequate sensitive, reproducible, and specific for the determination of Naproxen in bulk as well as in tablet dosage forms.

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Abdul Waheed*, Swati Pathak, Roohi Mirza
Department of Pharmacology,
Amity Institute of Pharmacy,
Amity University, Noida, U.P., India
*abdul.waheed2050@gmail.com

ABSTRACT
Epilepsy is a chronic brain disorder characterized by tendency to recurrent seizures or fits. The seizures can leads to loss of consciousness, disturbance of movement, muscle spasms, autonomic and mental functions. Epilepsy is developed because of imbalance in nerve signalling chemical called neurotransmitters. During epilepsy, the level of excitatory neurotransmitter glutamate increases and the level of inhibitory neurotransmitter GABA decrease. These lead to abnormal signalling in brain causes epilepsy. Primary diagnosis of epilepsy includes eye–witness and family history. Electroencephalograph (EEG) is the cornerstone for diagnosis of epilepsy and measures the brain wave activity. Neuroimaging like computed tomography (CT) scan, magnetic resonance imaging (MRI) and positron emission tomography (PET) techniques are used to diagnose abnormalities in structure and function of brain. Video recording is also useful for the monitoring of epileptic events. The most common approach of treatment is to prescribe antiepileptic drugs (AEDs). Three generations of AEDs including phenytoin, valproate, carbamazapine, lamotrigine, Oxcarbazepine, Primidone,Phenobarbitone,Gabapentin, Topiramate, Levetiracetam, Felbamate, Rufinamide, Zonisamide, Tiagabinand Vigabatrin etc. are prescribed. These AEDs have some teratogenic effects on  pragnent woman and lactating mother; need precautions. Instead of  pharmacological approaches, Non-pharmacological approaches also used for the treatment of epileptic seizures like ketogenic diet, atkins diet, yoga etc. Thr purpose of this review is to update the current knowledge on epilepsy classification, diagnostics, approaches of treatment, pathophysiology, mechanism of epileptogenesis and teratogenic effects.