Articles

2 September 2012

OVERVIEW ON: ATTRITION IN PHARMACEUTICAL MARKETING, CAUSES AND ITS MEASURES

About Authors:
Jeevan Sharma¹*, Davidson Rajesh²
¹B.Pharmacy, JSS college of pharmacy Ooty
²Regional manager, Natco Pharma litmited, Chennai
*jeevan.pharma@yahoo.com

ABSTRACTS:
Attrition refers to the reduction in staff and employees in a company through normal means, such as retirement and resignation. The primary focus of this article is to present the high rate of attrition seen in the pharmaceutical marketing industry , its causes and controlling strategy for retentions of pharma sales representatives. Though attrition is a natural phenomena in all industries , Indian Pharma marketing industries is worst plagued by It. After IT and BPO , pharma marketing industries experience the greatest rate of employee leaving the company for various reasons. While global pharma marketing attrition rate is 10-12% per annum, the rate of employees who leave the organization in India is 25 -30 %. The attrition is more prevalent in the middle and junior management level.
31 August 2012

ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF LAMIVUDINE BY USING RP-HPLC

About Authors:
Y. Kranthi Kumar*, Y.Prathyuha
Department of Pharmaceutical Analysis,
Venkateshwara Institute of Pharmaceutical sciences
Cheralapally, Nalgonda- 508001
*kk16052@gmail.com

Introduction
The present work deals with the studies carried out on the development and validation of RP-HPLC for the Lamivudine. Now a days the solutions have gained a lot of importance due to greater patient acceptability, increased potency, multiple action, fewer side effects and quicker relief.
31 August 2012

PREPARATION AND EVALUATION OF BUCCOADHESIVE BILAYER TABLETS OF ROPINIROLE HYDROCHLORIDE

About Authors:
M.Sateesh Kumar, C.Aparna*, Nalini Shastri, M.Sadanandam.
Department of Pharmaceutics, Sri Venkateshwara College of pharmacy,
Madhapur, Hyderabad-500081, India.
*sateeshmkt@gmail.com

Abstract:
Ropinirole hydrochloride buccoadhesive bilayered tablets containing bioadhesive layer and drug free backing layer were formulated to release the drug for extended periods of time with reduction in dosing frequency. The tablets were prepared by direct compression method using bioadhesive polymers like Carbopol934P, Methocel K4M, Methocel K15M, Sodium carboxy methyl cellulose, PVP K-30, Sodium alginate and Hydroxy propyl cellulose alone or in combination, Ethylcellulose has incorporated as an impermeable backing layer. Tablets were evaluated for weight and content uniformity, thickness, hardness, surface pH, swelling index, exvivo mucoadhesion time, invitro drug release and invitro drug permeation. The modifiedinvitro assembly was used to determine and compare the bioadhesive strength of tablets with fresh porcine buccal mucosa as a model tissue All characteristics of formulated tablets were shown to be dependant on composition of bioadhesive materials used. Maximum bioadhesion strength was observed for tablets formulated with Carbopol 934P. Carbopol 934P and Methocel K4M in the ratio of 1:1 could be used to design effective and stable buccoadhesive tablets of ropinirole hydrochloride.

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30 August 2012

A GENERAL OVERVIEW ON: STRESS AND ADAPTOGENS

About Author:
Sachin Kaushik
P.G. Department of Pharmacology,
B.L.D.E.A.’s college of Pharmacy,
Bijapur- 586103, Karnataka,India.
sachin_2004_kaushik@yahoo.com

ABSTRACT
In this general overview, we discussed about stress, types of stress, mechanism and its management. According to the report of WHO, approximately 450 million people suffer from mental or behavioral disorders like stress. This amounts to 12.3% of the global burden of disease and predicted to rise up to 15% by 2020. Therefore there is a need of an effective management to control stress and stress induced disorders.
30 August 2012

PROSPECTIVE ANALYSIS ON USE OF COMMON ANTI-ULCER DRUGS

About Authors:
Kalyan K Sarkar*¹, Dr.Gouranga Das²
¹B.Pharm student of 2011 at Institute of Pharmacy,
Govt. Of West Bengal,Jalpaiguri
²,Lecturer,Institute of Pharmacy,Govt of West BengalJalpaiguri
*kalyankrsarkar@gmail.com

ABSTRACT:
A hospital based prospective study was carried out on the patients who were admitted in the surgical and medical in-patients department (IPD) of that therapeutic care unit atJ alpaiguri, West Bengal. Only willing patients were included in our study. Question series was prepared for patient's interview which include age, sex, disease conditions, generic name, brand name of the anti ulcer drugs used and total cost of medication on our study period. The main objective of this study was to find out the actual sketch related to use of anti ulcer drugs in recent days. And finally In our study we have found that patients with various disease such as cardio vascular disease, abdominal pain, abnormal vomiting etc. were given anti ulcer drugs with main medication.
29 August 2012

DEVELOPMENT AND VALIDATION OF STABILITY INDICATING RP-HPLC METHOD FOR ESTIMATION OF TADALAFIL AND DAPOXETINE HCL IN SOLID DOSAGE FORM

About Authors:
CHIRAG S. RAJPARA*¹, JAWED AKHTAR¹, AMIT KHANDHAR²
1. Department of Quality Assurance, School of Pharmaceutical Sciences, Jaipur National University, Jagatpura, Jaipur-302025, Rajasthan, India.
2. Zydus cadila pharma, moraiya,ahmedabad.
*chiragrajpara2601@gmail.com

ABSTRACT
* A simple, specific, accurate and stability-indicating reversed phase high performance liquid chromatographic method was developed for simultaneous estimation of Tadalafil and Dapoxetine HCL, Water Symmetry C-18 (150 x 4.6 mm),5 µ and a mobile phase composed of Buffer : Acetonitrile (65:35)

* The retention time of Tadalafil and Dapoxetine HCL were found to be10.08 and 4.45 min respectively. Linearity was established for Tadalafil and Dapoxetine HCL in the range of 8.0-60 μg/ml and 24.0-180.0 μg/ml respectively. The percentage recovery of Tadalafil and Dapoxetine HCL were found to be in the range of 99.7-100.6% and 98.07-99.09% respectively. The drug was subjected to acid and alkali hydrolysis, oxidation, dry heat and photolytic degradation. The degradation studies indicated, Tadalafil showed degradation in acid and alkali while it was found stable in H₂O_2,photolytic and in presence of dry heat and Dapoxetine showed degradation in thermal and peroxide while it was found stable in rest of parameters . The degradation products of Tadalafil and Dapoxetine HCL in acidic, alkaline conditions were well resolved from the pure drug with significant differences in their retention time values. This method can be successfully employed for the quantitative analysis of Tadalafil and Dapoxetine HCL in bulk drugs and formulations.
29 August 2012

siRNA TECHNOLOGY:AN EMERGING TREND IN THERAPEUTICS

About Authors:
Vaibhav Patel*, Punit Bhatnagar, Gopal Rai, Alok Pal Jain
Guru Ramdas Khalsa Institute of Science & Technology (Pharmacy),
Jabalpur
*vaibhavpatel281@gmail.com

Introduction
Gene therapy by small interfering RNAs (siRNAs) hasbeen emerging as innovative nucleic acid medicines with increasing knowledge on the molecular mechanisms of endogenous RNA interference. Gene silencingis a promising tool for the treatment of numerous human diseases that cannot be cured by rational therapies. The primary success of siRNA applications depends on suitable vectors to deliver therapeutic genes.
28 August 2012

SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NOVEL HETEROCYCLES DERIVED FROM 2-ARYLIDENE-1-TETRALONES

About Authors:
Roshni Patel*, Prof. Arun Parikh, Prof. Vijayalakshmi Gudaparthi
Department of Pharmaceutical Chemistry, L.J.Institute of Pharmacy,
S.G.Highway, Ahmedabad-382210
*roshanimpharm@gmail.com

ABSTRACT
Medicinal chemistry involves chemical aspects of identification, and then systematic, thorough synthetic alteration of new chemical entities to make them suitable for therapeutic use. Indazoles have an important role in medicinal chemistry. Indazole nucleus is an important class of nitrogen containing heterocyclic widely used as key building block for the synthesis of various pharmaceutically important agents. Indazole possess wide range of biological activities such as bactericidal, fungicidal, analgesic, antihypertensive, anti-inflammatory and antitumor. In the present study we have synthesized some novel 3,3a,4,5-tetrahydro-2-(substituted benzenesulphonyl)-3-(substituted phenyl)-2H-benzo[g]indazoles, by condensation of 1-tetralone with different substituted aromatic aldehydes and the resulted 2-(substituted benzylidene)-3,4,-dihydronaphtalen-1-ones on reaction with hydrazine hydrate in methanol followed by treatment with different substituted sulfonyl chlorides in pyridine gave the titled compounds.The synthesized compounds were characterized by IR, NMR and Mass spectral analysis. All newly synthesized derivatives were evaluated for antibacterial activity against gram + ve and gram-ve bacteria B.cereus, S.aureus and E.coli respectivelyand antifungal activity againstC.albicans and all the synthesized compounds showed significant antibacterial and antifungal activity.

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28 August 2012

RISK OF HYPERTENSION IN DIABETES PATIENT AS COMPARED TO NON DIABETIC

About Authors:
Gupta S^*, Singal A
Apex Institute Of Pharmaceutical Sciences,
Jaipur, Raj., India
*somesh.gupta88@gmail.com

Abstract
The aim of the present study was to correlate the occurrence of hypertension in the diabetics’ patient by the survey report on hypertension associated with diabetics’ patient. The effect of this study is symbolize that 70% patient have diabetes with hypertension and 30% patient with hypertension only so we can say that in this survey as the BGL increased leads to increased in B.P. And it was also found to be that aged patients have more risk of diabetes. Over 60- 70 year age group patient have 40% risk to get diabetes.
27 August 2012

FORMULATION AND EVALUATION OF TASTE MASKED ORODISPERSIBLE TABLETS BY ION – EXCHANGE RESINS

About author:
Ashish Vishwakarma
Department of Pharmaceutics,
Chandigarh College of Pharmacy,
Mohali-140307
ashish1931@gmail.com

ABSTRACT-
Acceptability of any drug dosage form mainly depends upon its taste i.e. mouth feel. In the formulation of oro-dispersible tablet of bitter drug, the main challenge is to mask the bitter taste of drug, because the drug is dispersed and released in mouth. This is more essential in the formulation for pediatric and geriatric, bed ribbon and non-cooperative patients. There are many methods of taste masking but the main objective of this article is to explore method, technology and evaluation to mask taste of bitter drug by ion-exchange resins. Here we will study the formulation and evaluation of various oro-dispersible tablets of bitter drug. This is more economical, easiest and efficient method for taste masking.