Articles

About Authors:
Jomy Joy, Dr. Anantha Nagappa
Manipal College of Pharmaceutical Sciences,
Manipal University,
Karnataka, India

ABSTRACT
In the age of information, the applications of business have become not only simple but also of high impact. The impact of internet on society can be felt by popularity of social media like Facebook, twitter, orkut etc. The application of internet to access drugs and diagnostics which begin early in advent of infoage has matured into portals or virtual drugs stores popularly known as internet pharmacy. The advent of internet pharmacy and access of drugs and diagnostics is gaining popularity due to cost effectiveness, high speed delivery to door step of patients. The patient can order medicines from their own home in privacy.

About Authors:
Rakesh Bhatia
School of Pharmaceutical Sciences, Department of Chemistry,
Jaipur National University, Jaipur-302025,
Rajasthan, India

ABSTRACT
QSAR has been applied extensively and successfully over several decades to find predictive models for activity of bioactive agents. QSAR have brought revolution in drug discovery process by thedevelopment of mathematicalrelationships linking chemical structures and pharmacological activity in quantitative manner of series of compound. The mathematical relationships between molecular descriptors and activity are used to find the parameters affecting the biological activity and/or estimate the property of other molecules. Description of the molecular structure, electronic orbital reactivity and the role of structural and steric components have been the subject of mathematical and statistical analysis. This review seeks to provide an evolution of QSAR and development of receptor theory.

About Authors:
Soujanya J, Silambujanaki P, Leela Krishna V
Department of Pharmacology, SRM College of Pharmacy,
SRM University, Kattankulathur-603203,
Kancheepuram Dist.,
Tamil Nadu, India

Abstract
Holoptelea integrifolia, Planch. is a widely used herb in traditional medical systems of India.It is an important pollen allergen of India andsensitizes almost 10% of the atopic population in Delhi.Various parts of Holoptelea integrifolia, a roadside plant, are indicated by Charaka Samhitha, Sushrutha Samhitha and other traditional systems for the treatment of inflammations, acid gastritis, dyspepsia, flatulence, colic, intestinal worms, vomiting, wounds, vitiligo, leprosy, filariasis, diabetes, haemorrhoids, dysmenorrhoea and rheumatism.The present review is therefore, an effort to give a detailed survey of the literature on its pharmacological, traditional and phytochemical properties

About Authors:
Das Saumya¹*, Basu saumya Priya¹, Das Manas Kumar², Das Sanjita¹
1. Institute of Pharmaceutical Technology, NIET, Greater Noida, U.P., India.
2. Department of Pharmacy,
IEC-CET,
Greater Noida, U.P.,
India.

Introduction
Cancer has been one of the greatest scourges of mankind since time immemorial. It may be regarded as a series of malignant diseases characterized by (i) abnormal growth of cells (ii) ability to invade adjacent tissues and even distant organs and (iii) the eventual death of the affected patient if the tumor has progressed beyond the stage where it can be successfully removed. The incidence of cancer is expected to rise worldwide notably because of increase in life expectancy, changes in lifestyle patterns and environmental factors. Over the years, an increased understanding of cancer at cellular, molecular and genetic levels is opening up enormous opportunities to interrupt its initiation and progression. Although rapid strides have been made in treatment of cancer, there still remain many stumbling blocks in achieving cancer prevention and cure.

About Authors:
Sachin Saxena*¹,Pankaj Sharma¹ ,Nimisha²
1-M Pharm (Pharmaceutics) , Amity Univerity,Lucknow
2-Lecturer,
Amity University,
Lucknow

Abstract:
Rapid developments in the field of molecular biology and gene technology resulted in generation of many macromolecular drugs including peptides, proteins, polysaccharides and nucleic acids in great number possessing superior  pharmacological efficacy with site specificity and devoid of unwanted and toxic effects. However, the main impediment for the oral delivery of these drugs as potential therapeutic agents is their extensive presystemic metabolism, instability  in acidic environment resulting into inadequate and erratic oral absorption. Parentral route of administration is the only  established route that overcomes all these drawbacks associated  with  these  orally  less/inefficient  drugs  but,  these   formulations  are  costly,  have  least  patient compliance, require repeated administration, in addition to the other hazardous effects associated with this route. Buccal drug delivery leads direct access to the systemic circulation through the internal jugular vein bypasses drugs from the hepatic first pass metabolism leading to high bioavailability. Buccal route is an attractive route of administration for systemic drug delivery. Buccal bioadhesive films, releasing topical drugs in the oral cavity at a slow and predetermined rate, provide distinct advantages over traditional dosage forms for treatment of many diseases.

About Authors:
Snehal V.Chopade, Dr.V.R.Patil - Principle
TVES College of pharmacy,
Faizpur accredited by North Maharashtra University,
Jalgaon

Abstract:
UPLC can be regarded as new invention for liquid chromatography. UPLC refers to Ultra Performance Liquid Chromatography. UPLC brings dramatic improvements in sensitivity, resolution and speed of analysis can be calculated. It has instrumentation that operates at high pressure than that used in HPLC & in this system uses fine particles(less than 2.5µm) & mobile phases at high linear velocities decreases the length of column, reduces solvent consumtion & saves time.
This review introduces the theory of UPLC, and it can summarizes some of the most recent work in the field.

About Authors:
Sahithya Bitragunta, Ponnuru Venkata Suresh, Nadendla RamaRao
Chalapathi institute of pharmaceutical sciences,
Lam,Guntur,
India.

Abstract:
In 1960’s, different countries used to have different set of guidelines and laws for the registration and marketing of pharmaceuticals. But tragedies like Thalidomide disaster made harmonization of all technical requirements which are required for the registration of pharmaceuticals for the human use. Thus ICH has been launched in 1990 by drug regulatory authorities and pharmaceutical industrial members of Europe, Japan and US with an objective of providing guidelines to ensure the registration and marketing of safe, effective and high quality medicines.

About Authors:
Pushpendra Kumar Patel*,  Narendra Prajapati , Jyoti Sahu
M. Pharma, T.I.T. College of Pharmacy,
Bhopal,
M.P. India

Abstract
It is a very well accepted fact that food, cloth and shelter are essential stuff for human beings, but the real fact behind these are only to achieve  good health , so that one can survive and enjoy the charm of god gifted life. As the health is prime importance than any of others, so it’s novel responsibility of that person to keep the world healthy, and that person is proudly called as health care professional, Dr. and pharmacist both comes under it, but the pharmacist is the base of health care profession. A person who is directly and actively involved in the life cycle of medicine. It concludes study from new entity to its elimination. Simply the person deals with biochemical mechanism of action of drug, drugs therapeutic role, side effect, potential interaction, and monitoring parameter.

About Authors:
Middha Akanksha*, Kataria Sahil, Sandhu Premjeet, Arora Praveen
Seth G. L. Bihani S.D. College of Technical Education,
Institute of Pharmaceutical Sciences and Drug Research,
Sri Ganganagar, Rajasthan,
INDIA
*Akankshamddh@gmail.com

Abstract
Nuclear Magnetic Resonance (NMR) Spectroscopy is not limited to the study of protons. Any element with a nuclear spin (¹³C, ¹⁷O, ¹⁹F, ³¹P and many others) will give rise to an NMR signal.Carbon-13 NMR (¹³C NMR or referred to as carbon NMR) is the application of nuclear magnetic resonance (NMR) spectroscopy applicable to carbon. It is similar to proton NMR (1 H NMR) and allows the identification of carbon atoms whereas in other identification of H. As such ¹³C NMR is an important tool in chemical structure elucidation in organic chemistry. ¹³C NMR detects only the 13C isotope of carbon, whose natural abundance is only 1.1%, because  the main carbon isotope, 12 C, is not detectable by NMR since it has zero net spin.