Articles

About Authors:
Sachin Saxena*¹,Pankaj Sharma¹ ,Nimisha²
1-M Pharm (Pharmaceutics) , Amity Univerity,Lucknow
2-Lecturer,
Amity University,
Lucknow

Abstract:
Rapid developments in the field of molecular biology and gene technology resulted in generation of many macromolecular drugs including peptides, proteins, polysaccharides and nucleic acids in great number possessing superior  pharmacological efficacy with site specificity and devoid of unwanted and toxic effects. However, the main impediment for the oral delivery of these drugs as potential therapeutic agents is their extensive presystemic metabolism, instability  in acidic environment resulting into inadequate and erratic oral absorption. Parentral route of administration is the only  established route that overcomes all these drawbacks associated  with  these  orally  less/inefficient  drugs  but,  these   formulations  are  costly,  have  least  patient compliance, require repeated administration, in addition to the other hazardous effects associated with this route. Buccal drug delivery leads direct access to the systemic circulation through the internal jugular vein bypasses drugs from the hepatic first pass metabolism leading to high bioavailability. Buccal route is an attractive route of administration for systemic drug delivery. Buccal bioadhesive films, releasing topical drugs in the oral cavity at a slow and predetermined rate, provide distinct advantages over traditional dosage forms for treatment of many diseases.

About Authors:
Snehal V.Chopade, Dr.V.R.Patil - Principle
TVES College of pharmacy,
Faizpur accredited by North Maharashtra University,
Jalgaon

Abstract:
UPLC can be regarded as new invention for liquid chromatography. UPLC refers to Ultra Performance Liquid Chromatography. UPLC brings dramatic improvements in sensitivity, resolution and speed of analysis can be calculated. It has instrumentation that operates at high pressure than that used in HPLC & in this system uses fine particles(less than 2.5µm) & mobile phases at high linear velocities decreases the length of column, reduces solvent consumtion & saves time.
This review introduces the theory of UPLC, and it can summarizes some of the most recent work in the field.

About Authors:
Sahithya Bitragunta, Ponnuru Venkata Suresh, Nadendla RamaRao
Chalapathi institute of pharmaceutical sciences,
Lam,Guntur,
India.

Abstract:
In 1960’s, different countries used to have different set of guidelines and laws for the registration and marketing of pharmaceuticals. But tragedies like Thalidomide disaster made harmonization of all technical requirements which are required for the registration of pharmaceuticals for the human use. Thus ICH has been launched in 1990 by drug regulatory authorities and pharmaceutical industrial members of Europe, Japan and US with an objective of providing guidelines to ensure the registration and marketing of safe, effective and high quality medicines.

[adsense:336x280:8701650588]

About Authors:
Pushpendra Kumar Patel*,  Narendra Prajapati , Jyoti Sahu
M. Pharma, T.I.T. College of Pharmacy,
Bhopal,
M.P. India

Abstract
It is a very well accepted fact that food, cloth and shelter are essential stuff for human beings, but the real fact behind these are only to achieve  good health , so that one can survive and enjoy the charm of god gifted life. As the health is prime importance than any of others, so it’s novel responsibility of that person to keep the world healthy, and that person is proudly called as health care professional, Dr. and pharmacist both comes under it, but the pharmacist is the base of health care profession. A person who is directly and actively involved in the life cycle of medicine. It concludes study from new entity to its elimination. Simply the person deals with biochemical mechanism of action of drug, drugs therapeutic role, side effect, potential interaction, and monitoring parameter.

About Authors:
Middha Akanksha*, Kataria Sahil, Sandhu Premjeet, Arora Praveen
Seth G. L. Bihani S.D. College of Technical Education,
Institute of Pharmaceutical Sciences and Drug Research,
Sri Ganganagar, Rajasthan,
INDIA
*Akankshamddh@gmail.com

Abstract
Nuclear Magnetic Resonance (NMR) Spectroscopy is not limited to the study of protons. Any element with a nuclear spin (¹³C, ¹⁷O, ¹⁹F, ³¹P and many others) will give rise to an NMR signal.Carbon-13 NMR (¹³C NMR or referred to as carbon NMR) is the application of nuclear magnetic resonance (NMR) spectroscopy applicable to carbon. It is similar to proton NMR (1 H NMR) and allows the identification of carbon atoms whereas in other identification of H. As such ¹³C NMR is an important tool in chemical structure elucidation in organic chemistry. ¹³C NMR detects only the 13C isotope of carbon, whose natural abundance is only 1.1%, because  the main carbon isotope, 12 C, is not detectable by NMR since it has zero net spin.

About Authors:
Amol A. Dambal
Department of Pharmacognosy and Phytochemistry
Govt. College of pharmacy, Kathora naka,
Amravati-444604. (M.S.), INDIA.

ABSTRACT:
The Bark of Terminalia arjuna is considered as a  Cardioprotective and hypolipidemic in folklore medicine. In present investigation, the detailed pharmacognostic study of Terminalia arjuna Bark is carried out to lay down the standards which could be useful in future experimental studies. The study includes macroscopy, microscopy, preliminary phytochemical screening and physicochemical evaluation.

About Authors:
Jaideep Sharma
Guru jambheshwar university of science & technology    
Hisar,
Haryana

Cancer, known medically as a malignant neoplasm is a term for a large group of different disease, all involving unregulated cell growth. In cancer, cells divide and grow uncontrollably, forming malignant tumours, and invade nearby parts of the body. The cancer may also spread to more distant parts of the body through the lymphatic system or bloodstream. Not all tumours are cancerous. Benign tumours do not grow uncontrollably, do not invade neighbouring tissues, and do not spread throughout the body.
Healthy cells control their own growth and will destroy themselves if they become unhealthy. Cell division is a complex process that is normally tightly regulated. Cancer occurs when problems in the genes of a cell prevent these controls from functioning properly. These problems may come from damage to the gene or may be inherited, and can be caused by various sources inside or outside of the cell. Faults in two types of genes are especially important: ontogenesis, which drive the growth of cancer cells, and tumour suppressor genes, which prevent cancer from developing.

About Authors:
Debayan Dey*, G.D Pattnaik, Bijay kumar Sahoo
Dept.of Pharmaceutics
College of Pharmaceutical Sciences,
Puri, Orissa

INTRODUCTION
Oral administration is the most convenient and preferred means of any drug delivery to the systematic circulation. Oral controlled release drug delivery have recently been of increasing interest in pharmaceutical field to achieve improved therapeutic advantages, such as ease of dosing administration, patient compliance and flexibility in formulation. Drugs that are easily absorbed from gastrointestinal tract (GIT) and have short half-lives are eliminated quickly from the systemic circulation. Frequent dosing of these drugs is required to achieve suitable therapeutic activity.

[adsense:336x280:8701650588]

About Authors:
Nishant Gupta
Department of pharmaceutics,
B.N. College of pharmacy,
Udaipur-313002,
Rajasthan

ABSTRACT:
Paroxetine (PRX) crystals exhibit poor compressibility, poor flowability and its tablets show a tendency to cap. To improve the mechanical strength of tablets several kinds of “Paroxetine for direct compression” are present on the market. Current research demonstrated the best tablet properties with coated paroxetine (mass of tablets, diameter, height and mechanical strength, friability RSD<2%). Furthermore, coated paroxetine in combination with both investigated superdisintegrants such as Vivasol® and Polyplasdone® XL-10 shows faster disintegration time and dissolution rate in comparison to paroxetine for direct compression. Eventually, the major advantages of the formulation with coated paroxetine for industrial production are decrease of friability and superiority in terms of flowability, compressibility, quick disintegration and dissolution. Regarding the results, coating of PRX particles is beneficial for the manufacturing of tablets with immediate release.