Articles

About Authors:
Jigar Modi^*1, Dr. Jayvadan Patel¹, Dr. Hitesh chavda^2
1Nootan Pharmacy College, S.P. Sahkar Vidhyadham,
Kamana Crossing, Visnagar-384 315,
Dist – Mehsana, Gujarat, India.
²Shri Sarvajanik Pharmacy College,
Nr. Arvind Baug, Mehsana, Gujarat, India
*jigo_farmacy@yahoo.com

ABSTRACT:
Generally, controlled release dosage forms used in many applications. Superporous hydrogel is also one of them. It has lot of advantages over conventional hydrogel. Superporous hydrogel having faster swelling due to interconnected highly porous structure. Such other properties like slippery property, their mechanical strength and better foaming process are advantageous over conventional hydrogel. Its unique mechanism for achieving gastric retention, a number of hurdles have to be overcome for any approach to be clinically useful. For example, intra-gastric floating systems require the presence of gastric juice to be effective, and this may not be the case in the fasted state. Mucoadhesive systems can easily lose their mucoadhesive properties by interaction with any materials soluble in gastric juice. In this review, types of superporous hydrogel, their preparation, their characterizations and applications are discussed.

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About Authors:
Mr.Sanjay wasudeo upare^*, Dr.A.V.Chandewar, Dr.M.D.Kshirsagar, Mr.U.S.Koli and Mr.H.K.Pokale
M-Pharm IV semester (Pharmaceutics department)
Pataldhamal Wadhwani college of Pharmacy,
Yavatmal
*uparesanju81@gmail.com

ABSTRACT:
Lornoxicam is a non steroidal anti-inflammatory drug with analgesic properties. The purpose of this study was to develop a taste masked oral disintegrating tablet of poorly soluble Lornoxicam by direct compression technique with β-cyclodextrin (BCD) complexes using various super disintegrants like sodium starch glycolate, crospovidone and L-Hpc. Prepared tablets were evaluated for different properties like drug content, hardness, friability, disintegration time and in vitro dissolution study. The different formulations showed disintegration time between 21 to 33.66 s. Drug release showed time between the ranges of 5 to 30 min. Among all the formulations, L1 showed 97.79% drug release within 30 min. Thus, L1 was considered best among the other formulations.. The tablets showed enhanced dissolution hence better patient compliance.

About authors:
1.Shashi Kant*, Satinder Kumar,
Research scholar department of pharmacy.
2. Dr. Bharat Prashar
HOD & Associate professor 
Department of Pharmaceutical Sciences,
Manav Bharti University, Solan (H.P)
shashi_ranaute@yahoo.in

ABSTRACT :
In this review article we discussed about are monospecific identical immune cells that are all clones of a unique parent cell. Monoclonal antibodies have monovalent affinity, in that they bind to the same epitope.Given almost any substance, it is possible to produce monoclonal antibodies that specifically bind to that substance; they can then serve to detect or purify that substance. This has become an important tool in biochemistry, molecular the non-proprietary drug name ends in mabs,in this we discussed type of monoclonal antibodies,preparation,targeting of monoclonal antibodies as well as advantages and disadvantages of monoclonal antibodies. antibodies that are biology and medicine.

About Authors:
Joshi B.*, Agarwal P., Sahu D., Dashora A.
Geetanjali Institute of Pharmacy,
Udaipur Rajasthan, India
*bhavesh.joshi8@gmail.com

Abstract:
Antiaging is emerging class of cosmetics which combine the benefit of anti aging ingredients with the elegance skin feel and delivery system of cosmetics antioxidants, anti cellulites and anti microbial have been use in maintaining and enhancing human beauty. Anti aging ingredients also help to reduce the fine lines, increasing the moisture level and reduces wrinkles and puffness to keep the skin in good condition. New delivery system is a more effective solution for the skin aging resulting from photoaging. New vehicle like liposome and nanoparticles is a new generation for antioxidants with enhanced bioavailability and very stable activity. Our objective is to review present state of the art knowledge pertaining to mechanisms involved in skin aging, factor responsible for aging and various new ingredients use to treat aging defect.

About Authors:
Sachin Kaushik*, Dr. shivakumar Hugar
P.G. Department of Pharmacology,
B.L.D.E.A.’s college of Pharmacy,
Bijapur- 586103,
Karnataka,India
*sachin_2004_kaushik@yahoo.com

ABSTRACT:
In the present study antistress activity was assessed against anoxia tolerance, swimming endurance and cold restraint stress models. In anoxia tolerance test, the mean time of appearing first convulsion in mice was taken as end point to determine the time of anoxia.  In swimming endurance test the mean time of swimming performance was recorded.The end point taken was when the animals remained at the bottom of swimming tank for 10 sec. Biochemical estimation like glucose, cholesterol, triglycerides and BUN and weight of organs were measured in cold restraint stress model.

About Authors:
ATUL KABRA^* , PREMAL KAPADIA
Department of Pharmacology,
G.H.B Pharmacy college,
Aniyad, Gujarat
* atul.kbr@gmail.com

ABSTRACT:
The cardiovascular risk factors were significantly abnormally altered in diabetic rats when compared to normal control. The present study FLEt with low dose of OHA’s indicates the significant improvement in endothelial dependent vasodilatation because the percentage relaxation produced by acetylcholine was more significant when these groups were compared with diabetic control.However all the treated groups restored these changes significantly to normal conditions in diabetic rats when compared to diabetic control. The combined therapy of FLEt and Fluvastatin was found to be significantly effective. Moreover, this combination was also found to demonstrate synergistic behavior than pioglitazone plus fluvastatin.
We conclude that of preventive therapy with combination of FLEt with OHA’s (low dose) may prevent the endothelial dysfunction in diabetic patients (prediabetic state) due to free radical scavenging activity, metabolic control.

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About Authors:
¹Shashi Kant^*, Satinder Kumar,
Research Scholar Department of Pharmacy.
²Dr. Bharat Prashar
HOD & Associate professor,
Department of Pharmaceutical Sciences,
Manav Bharti University, Solan (H.P)
* shashi_ranaute@yahoo.in

Abstract:
In this general overview, we discussed about dentifrices, types of dentifrices, formulation, evaluation and its recent trends. There have been many dentifrices produced over the years, many focusing on marketing strategies to sell products, such as offering whitening capabilities. The most essential dentifrice recommended by dentists is toothpaste which is used in conjunction with a toothbrush to help remove food debris and dental plaque.