Herbal medicine in Treatment of Heart disease: Cardioprotective Activity of Terminalia belerica

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About Authors: Firoj Alam*, Vipra tomar, Ameena khatoon
Faculty of Pharmacy, Integral University,
Lucknow (U.P.)

ABSTRACT
Cardioprotection and prevention of cell ischemia/necrosis have been therapeutic targets for a long time. New therapies are needed to treat myocardial ischemia because current treatmenthas only its own limitation on survival and annual costs. The fruit is reported to have hepatoprotective, purgative, choleretic, and hypotensive effects. In a clinical study, Terminalia belerica was found to possess antispasmodic, anti-asthmatic and anti-tussive effects. The fruit extracts of Terminalia belerica have been evaluated for anti-mutagenic, antimicrobial and anti-HIV-1 activity. The plant is known to lower the levels of lipid in hypercholesterolemic animals and thus  prevent the development of atherosclerosis and myocardial infarction; Triphla and Terminalia belerica reduced the serum glucose level and showed marked antioxidant properties in alloxan-induced diabetic rats.Polyphenols with proteins may be the probable cause of the inhibitory. Gallic acid: 3,4,5- trihydroxybenzoic acid is demonstrable the hepatoprotective action extract of Terminalia belerica. The presence of saponins, triterpenoids, carbohydrates, tannins and proteins show the analgesic agent used in the management of chronic pain. Phenolic contents of T. bellerica having antioxidant activity.and reduced the level of cholestrol.and also reduced the serum trasminase, and bilirubin. Due to high efficacy and low toxicity and its anti-oxidant, anti-hyperlipedemic, Antihypercholesterolemic and cardiotonic effects, it will provide an accessible and cheaptraditional medicine source for treatment of cardiac disease in developing countries.

REFERENCE ID: PHARMATUTOR-ART-1133

INTRODUCTION:
The cardiovascular system is made up of the heart and blood vessels. Cardiovascular disease (CVD) is defined as any serious, abnormal condition of the heart or blood vessels (arteries, veins). Cardiovascular disease includes coronary heart disease (CHD), stroke, peripheral vascular disease, congenital heart disease, endocarditis, and many other conditions.

Cardiovascular Diseases (CVD) are the secondary cause of deaths in many parts of the world, although modern drugs are effective in preventing the disorders,their use is often limited because of their side effects and adverse reactions. A wide array of plants and its active principles, with minimal side effects, provide an alternate therapy for heart disease. Moreover, the plant kingdom represents a largely unexplored reservoir of biologically active compounds. Terminalia belerica Roxb. of family Combretaceae is distributed throughout. It is found in abundance in Madhya Pradesh, uttar Pradesh, Punjab, Maharashtra, and also in Ceylon and Malaya. It is used for various ailments in Indian Traditional System of Medicine. The famous myrabolan fruits Terminalia belerica is the best single herb for controlling Kapha. It is a powerful rejuvenative herb that nourishes the lungs, throat, voice, eyes and hair. It expels stones or other kapha-type accumulations in the digestive, urinary, and respiratory tracts.gastric ulcers, hemorrhoids, chronic diarrhea, dysentery, parasites, cholelithiasis, ophthalmia, headache, alopecia and premature graying, edema, rheumatism (topical), wounds (topical). (Kirtikar and Basu 1993, 1018-1019; Nadkarni 1976, 1203-04;)

NEED FOR HERBAL MEDICINE IN TREATMENT OF HEART DISEASE:
Herbal treatment for heart disease is not a new concept. People have been using herbs for hundreds of years to treat many chronic diseases, including the cardiovascular ones. Herbs were used to prevent and treat almost every disease long before the advent of modern medicine. Because of the rapidly growing popularity of allopathic medicine, many people today don"t even know if herbs can be very effective in treating even the otherwise incurable diseases. The best thing about herbal medicines is that they have very little or no side effects.

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