EVALUATION OF ANTI DIARRHEAL POTENTIAL OF CINNAMON LEAVES

 

RESULTS AND DISCUSSION
The acute toxicity study showed that oral administration of aqueous extracts of Cinnamonleaves to the mice up to 2000 mg/kg dose neither showed mortality nor any visible clinical signs of general weakness in the animals. The aqueous extract of Cinnamonleaves administered at the dose of 100, and 200 mg/kg showed 61.32% and 72.42% diarrhea respectively. This reduction in diarrheal episodes is significant and maximum effect is observed at the dose of 200mg/kg. This shows significant reduction in diarrheal episodes with maximum effect at 200mg/kg dose level. Whereas the standard group, Loperamide a standard, anti-diarrheal drug treated animal at the dose of 1mg/kg and 2 mg/kg showed significant reduction in diarrhoeal episodes (80.44% and 90.91% respectively). The study reveals that the aqueous and alcohol extracts exhibited significant diarrheal activity. The remarkable anti-diarrheal effect of Cinnamonleaves extracts against castor oil-induced diarrhea model proves to its efficacy in an extensive range of diarrheal conditions.

Table 1 Anti-diarrheal activity of various extracts of Cinnamonleaves and loperamide

Treatment (oral)

Dose

% protection

Weight of stools (g)

(Mean±  SEM)

Castor oil

10ml/kg

0.0

1.2846 ± 0.029

Aqueous extract

100mg/kg

61.32%

0.463 ± 0.0314*

200mg/kg

72.42%

0.351 ± 0.0293**

Loperamide

1mg/kg

2mg/kg

80.44%

90.01%

0.204 ± 0.0232**

0.127 ± 0.0642*

  **P < 0.01 and *P < 0.05 statistically (Mean±SEM) significant from control group (n=5)

TABLE 2- PHYTOCHEMOCAL SCREENING

Chemical constituents Aqueous extract

Aqueous extract

Tannins

+

Alkaloids

+

Flavonoids

+

Sugars

+

Glycosides

+

Terpenes

+

Starch

+

REFERENCES
1. V. Rajamanickam*, A. Rajasekaran, K. Anandarajagopal,D.Sridhara, K.Selvakumar And B.Stephen Rathinaraj. “Anti-Diarrheal Activity of Dodonaea Viscosa Root Extracts”, International Journal of Pharma And Bio Sciences Vol.1/Issue-4/Oct-Dec.2010.
2. G. C. Akuodor, I. Muazzam, M. Usman-Idris, U. A. Megwas, J. L. Akpan, K. C. Chilaka, D. O. Okoroafor, U. A. “Evaluation of the Antidiarrheal Activity of Methanol Leaf Extract of bombax Buonopozense in Rats., Ibnosina Journal of Medicine & Biomedical Sciences. Jan2011, Vol. 3 Issue 1, p15-20. 6p. 3 Charts.
3. A. Sangal, “Role of cinnamon as beneficial antidiabetic food adjunct: a review”, Advances in Applied Science Research, 2011, 2 (4):440-450.
4. Rafid Mohammed  Ali Hassan Wasfi, “Comparison the effect of Various Cinnamon plant  Extracts with Metformin in Blood Glucose level of alloxan-induced diabetic laboratory rats”, Kufa Journal For Veterinary Medical Sciences Vol. (2) No. (2) 2011.
5. Ukwuani A. N, Salihu S., Anyanwu F. C., Yanah Y. M., Samuel R, “Antidiarrhoeal Activity of Aqeous Leaves Extract of Vitex doniana”, International Journal of Toxicological and Pharmacological Research 2012; 4(3): 40-44.
6. Ankita Misra, Sharad Srivastava, Manjoosha Srivastava, “Evaluation of Anti Diarrheal Potential of Moringa oleifera(Lam.) Leaves” Journal of Pharmacognosy and Phytochemistry 2014; 2 (5): 43-46.
7. Hari Jagannadha Rao, Lakshmi, “Anti-Diarrhoeal Activity of the Aqueous Extract of the Bark of Cinnamomum Zeylanicum Linn in Mice”, Journal of Clinical and Diagnostic Research. 2012 April, Vol-6(2): 215-219.
8. S Meite*, J D N’guessan, C Bahi, H F Yapi, A J Djaman,and F Guede Guina, “Antidiarrheal Activity of the Ethyl Acetate Extract of Morinda morindoidesin Rats”, Tropical Journal of Pharmaceutical Research, June 2009; 8 (3): 201-207.
9. Shemsu Umer*, Alemu Tekeweand Nigatu Kebede, “Antidiarrhoeal and antimicrobial activity of Calpurnia aurealeaf extract”, BMC Complementary and Alternative Medicine2013,13:21.
10. G Balaji, M Chalamaiah, B Ramesh* Y Amarnath Reddy, “Antidiarrhoeal activity of ethanol and aqueous extracts of Carum copticum seedsin experimental rats”, Asian Pacific Journal of Tropical Biomedicine (2012)S1151-S1155.Bombax Buonopozense in Rats”, Ibnosina J Med BS 2011, 3(1):15-20.

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