Blockbuster Heart Drug Ticagrelor Faces Scrutiny Over Trial Integrity and Data Discrepancies
24 June 2025

Blockbuster Heart Drug Ticagrelor Faces Scrutiny Over Trial Integrity and Data Discrepancies

As AstraZeneca’s multibillion-dollar heart drug ticagrelor (marketed as Brilinta in the U.S. and Brilique in Europe) prepares to go off-patent, a fresh investigation by The BMJ has raised troubling concerns about the integrity of the trials that supported its approval. The antiplatelet medication has been widely used for over a decade to treat patients with acute coronary syndrome, but the evidence base it rests on is now under question.

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