Articles

About Authors:
Pankaj S. Waghere^1*, Malpani Amol²,
1Prin. K. M. Kundnani College of Pharmacy, Mumbai. Maharashtra, India.
2Roland Institute of Pharmaceutical Sciences, Berhampur. Orissa, India.
*waghere.pankaj@gmail.com

ABSTRACT
Hydrocolloids are naturally-occurring plant polysaccharide, in that gaur gum is most useful and validated natural plant polysaccharide. Guar gum and their derivatives are widely used in pharmaceutical dosage forms. Many are used as biodegradable polymeric materials to deliver active pharmaceutical ingredients. Natural polymers can be modified to obtain tailor-made materials for drug delivery systems and to compete with the synthetic biodegradable excipients available in the market. Natural polymers as a drug carrier material are of two types: polysaccharides and proteins. They found both in plants and animals providing several advantages over synthetic polymers.Gaur gums are preferred to those of synthetic origin due to their green, cost-effectiveness, nontoxic, easy availability and for suitable binder in tablet manufacture. The aim of this review is to provide an insight into the many potential applications of gaur gum as pharmaceutical natural excipients.

About Authors:
NITIN M, MOHAN REDDY U*
Department of Pharmacology,
H.K.E.S’s, Matoshree Taradevi Rampure Institute of Pharmaceutical Sciences,
Sedam Road, Gulbarga- 585 105, Karnataka
*mohanreddy.udumula@gmail.com

ABSTRACT
Gastric ulcer is one of the most prevalent gastrointestinal disorders, which affects approximately    5-10% of people during their life. The present study was aimed to find out the pharmacodynamic influence of vitamin E and esomeprazole and their combination on gastro intestinal parameters in pylorus ligation induced ulcers in rats in single and multiple dose studies.  Various parameters were studied in  pylorus ligation induced ulcer model viz. gastric volume, pH, total acidity, free acidity, and ulcer index.The antiulcer effect of the combination of vitamin E 0.9 mg/200 g and esomeprazole 0.54 mg/200 g b.w orally was compared with the reference standard esomeprazole 0.54 mg/200 g b.w orally. The ulcer index was calculated and other biochemical parameters of gastric juice were estimated. The ulcer index of combination showed significant (P < 0.05) reduction while other biochemical parameters like volume, pH, free acidity and total acidity of gastric juice showed highly significant (P < 0.001) reduction when compared to control and standard esomeprazole.

About Authors:
Manthan Shah
D.Pharm, B.Pharm, MBA(Marketing & Finance)
Assistant PMT
Sohm India Pvt Ltd
manthanshah.leo@gmail.com

About Authors:
Vishal Sharma^1*, Alankar Shrivastava^2
1Department of Pharmaceutics,
²Senior Lecturer Department of Pharmaceutical Analysis
B.R.NAHATA COLLEGE OF PHARMACY
(A SIRO Recognized by DSIR, Ministry of science & Technology, GOI)
MANDSAUR (M.P.) 458001
*vishus2010@gmail.com

Abstract
Antibiotics are chemical substances, either produced naturally by microorganisms or manufactured synthetically, that are lethal to other microorganisms. Antibiotic resistance (AR) describes the ability of a microorganism to be unaffected by (or resistant to) the effects of a particular antibiotic. A problem arises when a animal or person becomes infected with a disease-causing bacterium that harbors antibiotic resistance to the drug that would be the most suitable treatment for that infection.

India is a vast country of immense diversity.and for that the effectiveness of the antimicrobial was not same to all ,and the administration of them will either really cure or may act in opposite manner and will leads to the development os the antimicrobial resistance which is only due to the unaware use of the antibiotics.we had conducted the survey on some prescriptions of registered medicinal practitioner and find that there was an irrational use of antibiotic in our on community and this might be very serious as our survey is on the smallest level and what it may cause globally.So the use of antibiotic should be controlled.

About Authors:
Shah Chirag K.*, Umalkar Deepak, Dr. Rajesh KS.
Parul Institute of Pharmacy, Gujarat University,
Waghodia-391760, Dist. Vadodara,
Gujarat, India.
*cks2484@gmail.com

Abstract:
The present manuscript described the simple, rapid, accurate, sensitive, precise and economical Q- absorption ratio method for simultaneous determination of Cefixime and Moxifloxacin in combined tablet dosage form. Absorption ratio method uses the ratio of absorbances at selected wavelengths, one which is isoabsorptive point and other being the λ_max of the one of the components. Cefixime and Moxifloxacin shows isoabsorptive point at 275nm in 0.1N HCl. The second wavelength used is 295nm, which is λ_max of Moxifloxacin. The concentrations of the drugs were determined by using ratio of absorances at isoabsorptive point and at λ_max of Moxifloxacin. The method successfully applied to the Pharmaceutical formulation because no interference from the tablet formulation excipients was found. The results of analysis have been validated statistically and by recovery studies.

About Authors:
T.R.PARTHASARATHI*, M.VANITHA SRI.
BIOANALYTICAL DEPARTMENT,
QUEST LIFE SCIENCES PVT. LTD, SDF III, MEPZ,
TAMBARAM, CHENNAI- 600 045, INDIA.
*parthu_14@yahoo.co.in

ABSTRACT :
A novel isocratic reverse-phase high performance liquid-chromatography method for determination of asenapine maleate was developed and validated after optimization of various chromatographic conditions. Samples were separated on a waters x-terra C₁₈ (100 mm × 4.6 mm, 3.5 μ) analytical column. The mobile phase used was acetonitrile: 0.1M phosphate buffer (p^H 3.2) 65:35%v/v operated at 30 °C column oven temperature was pumped at a flow rate of 1.0 mL min⁻¹ and the column eluents were monitored at a wavelength of 272 nm. When sample was injected into the Finnigan surveyor high performance liquid-chromatography system through Finnigan surveyor auto-sampler injector, separation was achieved within 5.0 min. The present method demonstrated was validated with the acceptable values for selectivity, linearity (within the expected concentration range (10–50 μg mL⁻¹; r² > 0.999)), recovery (>95%), precision (%RSD < 2.0), sensitivity (limit of detection: 1.85 µg mL⁻¹ and lower limit of quantification: 2.34 µg mL⁻¹), robustness, and ruggedness.

About Authors:
ATUL KABARA*, RUCHI THAKKAR, NITIN PATEL
Department of Pharmacology
G.H.B Pharmacy college,
Aniyad,Gujarat
*atul.kbr@gmail.com

ABSTRACT:
Lawsonia inermiscommonly known as Henna is a perineal herbaceous plant belonging to family Lauraceae. Traditionally it has been used to treat skin disease, dysentery, bronchitis, anemia and inflammation . The aim of present study was to investigate the anti-inflammatory activity of aqueous extract of Lawsonia leaves in rats. Aqueous extract was administered at a dose of 250mg/kg and 500mg/kg.

About Author:
Patel Chirag J*, Asija Rajesh, Asija Sangeeta, Mangukia Dhruv
Maharishi Arvind Institute of Pharmacy,
Department of pharmaceutics, Jaipur,
Rajasthan, India.
*chirag.bangalore@gmail.com

ABSTRACT
Amongst the various carriers, few drug carriers reached the stages of clinical trials where liposome shows strong potential for effective drug delivery to the site of action. Liposomes are vesicles having concentric phospholipid bilayers. Molecules from low molecular weight to high molecular weight have been incorporated in liposomes. The water soluble compounds/drugs are present in aqueous compartments while lipid soluble compounds/drugs and amphiphilic compounds/drugs insert themselves in phospholipid bilayers. Drug encapsulated in liposomes include doxorubin, cisplatin, vincristin, melphalan, sarcolycin, daunorubicin, etoposide, etc. The liposomes containing drugs can be administrated by many routes (intravenous, oral inhalation, local application, ocular) and these can be used for the treatment of various diseases. Their predominance in drug delivery and targeting has enabled them to be used as therapeutics tool in fields like tumour targeting, gene and antisense therapy etc. This review discusses the advantages, disadvantages, mechanism, classification, method of preparation, characterization and application of liposomes.

About Authors:
L.Kalaiselvi^1*, Mr.R.Ulaganathan^2
1 B.Pharm, II M.Tech Nanoscience&Technology,
² Assistant Professor, B.Sc, M.Sc., M.Tech
Department of Biotechnology, Udaya school of Engineering,
Nagercoil, Kanyakumari dt.
*klkselvi@gmail.com

ABSTRACT:
Nanoparticle based systems have significant prospective for diagnosis, treatment and prevention of tuberculosis (TB) Gelatin nanoparticle derived from marine sources (fish skin, bone and fins) has been looked upon as a possible alternative to bovine and porcine. Fish gelatin nanoparticle synthesis by two step desolvation method, it was stable nanoparticles and confirm through Scanning electron microscopy (SEM).These nanoparticle were used as carrier for rifampicin. Our aim to develop a Nano particulate carrier of rifampicin for controlled delivery as well as reduced toxicity. In this study, rifampicin loaded fish gelatin nanoparticle was fabricated by an absorption/adsorption method. The effect of several variables on the Nanoparticle’s characteristics was calculated.