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  • ESSENTIAL ELEMENTS OF PATENT

    About Authors:
    Jatin  Patel1*, Prof. Rajesh Kumar Dholpuria2, Dhiren Shah1
    2(Professor, Head of Department of pharmacognosy),
    1Seth G.L. Bihani S.D. College of Technical Education,
    Institute of Pharmaceutical Sciences and Drug Research,
    Sri Ganganagar, Rajasthan, INDIA
    *Patelj313@yahoo.in

    ABSTRACT
    Patent Right varies from country to country. In India the law which govern patent right is "Indian Patent Act 1970". Indian Patent Act, 1970 grants exclusive right to the inventor for his invention for limited period of time. Generally 20 years time has been granted to the patent holder but in case of inventions relating to manufacturing of food or drugs or medicine it is for seven years from the date of patent. There is certain legal procedure which needs to be followed in order to register. There are several attorney helping inventor in patent registration by providing them best well informed knowledge. In India patent registration can be filed individually or jointly. In case of deceased inventor this can be done his legal representative on behalf of him. All the required documents need to be filed along with the application form. Only after verification registration certificate is provided to the applicant.

  • PACKAGING AND LABELLING CONTROL ACCORDING TO GLOBAL GMP

    About Authors:
    *Tarun Patel, Prof. Dr. Vipin Kukkar, Krunal Parik
    Seth G.L. Bihani S.D. College of Technical Education,
    Institute of Pharmaceutical Sciences and Drug Research,
    Sri Ganganagar, Rajasthan, INDIA
    *tarunpatel35@gmail.com

    ABSTRACT:
    In pharma industry Packaging and Labelling plays very important role for improvements of attraction to human beings. So by improving our packaging and labeling style we can easily improve our product market value. Green packaging is also an alternative to make packaging more environmental friendly which would not affect the nature in any way. The most desirable solution is “use less, discard less, save more, reuse more”In this review article we discuss briefly about the requirement of packaging and labeling control of product according to different GMPs.

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  • REVIEW ON APPLICATIONS OF POLYMERS IN PHARMACEUTICAL FORMULATIONS

    About Authors:
    Darveshwar Jagdeep D*, Mule Madhav S1, Birajdar Shivprasad M2
    *NRI Institute of Pharmaceutical Science, Bhopal, India
    1School of Pharmacy, Swami Ramanand Teerth Marathwada University
    Vishnupuri, Nanded-431606, Maharashtra, India,
    2Department of Quality Assurance, Maharashtra College of Pharmacy,
    Nilanga-413521, Maharashtra, India
    *jagdeepdd@hotmail.com, birajdar100@gmail.com

    Abstract:
    Polymers have played indispensable roles in the preparation of pharmaceutical products. Their applications range widely from material packaging to fabrication of the most sophisticated drug delivery devices. This review includes various polymers used in pharmaceutics based on their applications. The review focuses on the use of pharmaceutical polymer for controlled drug delivery applications. Examples of pharmaceutical polymers and the principles of controlled drug delivery are outlined and applications of polymers for controlled drug delivery are described. The field of controlled drug delivery is vast therefore this review aims to provide an overview of the applications of pharmaceutical polymers. General pharmaceutical applications of polymers in Dental Medicine, Ophthalmic Drug Delivery, Gene Delivery, Preparation of micro spheres etc. are also discussed briefly.

  • STABILITY INDICATING HPTLC METHOD DEVELOPMENT AND VALIDATION FOR CINACALCET HYDROCHLORIDE API

    About Authors:
    Gautam Kumar
    SRM college of pharmacy, SRM University
    Chennai 600 033.
    gautamsinghsrmcp@gmail.com

    Abstract
    The aim of the present work to develop validated RP-HPLC method which determines stress stability and concentration of Cinacalcet hydrochloride in synthetic mixture as per ICH guidelines. Separation was performed using Camag Linomat V semi Automated sample applicator with TLC Scanner III. Stationary Phase consisting of TLC plates (Merck) pre coated with silica gel 60F254 on Aluminum Sheets was used. Mobile phase comprising of Methanol: Water: Glacial acetic acid (5:5:0.2v/v/v) was used. All the system suitability parameter was found within the range. The method was extensively validated for specificity, linearity, accuracy, precision, recovery, limit of quantitation and detection. The Cinacalcet hydrochloride was found to be highly labile to alkaline and acid hydrolysis compared to oxidation. Chromatographic peak purity results indicated the absence of co-eluting peaks with the main peak of Cinacalcet, which demonstrated the specificity of assay method for estimation of Cinacalcet in presence of degradation products. The proposed method can be used for routine analysis of Cinacalcet in quality control laboratories.

  • RECENT ADVANCE IN PULSATILE DRUG DELIVERY SYSTEM

    About Authors:
    Dhirendra C. Patel1*, Ritesh B. Patel1, Gargi B. Patel2
    1Department of Pharmaceutics and Pharmaceutical Technology;
    S.K. Patel College of Pharmaceutical Education and Research;
    Ganpat University, Kherva, Mehsana, Gujarat, India.
    2Pharma Management & Regulatory Affairs,
    K.B. Institute of Pharmaceutical Education & Research, Gandhinagar, Gujarat, India.
    *dhiren.pharmacy@gmail.com

    Abstract:
    Oral controlled drug delivery systems represent the most popular form of controlled drug delivery systems for the obvious advantages of oral route of drug administration. However, there are certain conditions for which such a release pattern is not suitable like cardiovascular diseases, Diabetes mellitus, Asthma, Arthritis, Peptic ulcer etc. In such cases pulsatile drug delivery system is used in which release drug on programmed pattern i.e. at appropriate time & at appropriate site of action. Pulsatile Drug Delivery systems are basically time controlled drug delivery systems in which the system controls the lag time independent of environmental factors like pH, enzymes, gastro-intestinal motility, etc. The principle rationale for the use of pulsatile release is for the drugs where a constant drug release, i.e., a zero-order release is not desired. In chronopharmacotherapy drug administration is synchronized with biological rhythms to produce maximal therapeutic effect & minimum harm for the patient. Technically, pulsatile drug delivery systems administered via the oral route could be divided into two distinct types, the time controlled delivery systems and the site-specific delivery systems, thus providing special and temporal delivery. In recent pharmaceutical applications involving pulsatile delivery; multiparticulate dosage forms (e.g. pellets) are gaining much favor over single-unit dosage forms. Various pulsatile technologies have been developed on the basis of methodologies, these includes ACCU-BREAK™, AQUALON,  CODAS®, PRODAS®, SODAS®, MINITABS®, DIFFUCAPS®, OROS® etc. Designing of proper pulsatile drug delivery will enhance the patient compliance, optimum drug delivery to the target side & minimizing the undesired effects.

  • EVALUATION OF CRUDE DRUGS, MONO OR POLYHERBAL FORMULATION

    About Authors:
    Dhiren Shah*1, Jatin Patel, Krunal Parikh
    m.pharmacy
    Seth G.L. Bihani S.D. College of Technical Education, R.U.H.S.
    Sri Ganganagar, Rajasthan, INDIA
    *dhiren.pharmacist@gmail.com

    Abstract :
    Involved Evaluation and Standardization techniques for crude drugs, mono or Polyherbal Frormulation. They involved the macroscopic techniques, microscopic techniques, physical evaluation and biological evaluation. They also involved the Quantitative analysis of Organophosphorus insecticides, Organochlorine and pyrethroid insecticides, microbial content determination.

  • DRUG TARGETING: BASIC CONCEPTS AND DRUG CARRIER SYSTEMS- A REVIEW

    About Authors:
    Deepjyoti Kumari
    M.Pharm (Pharmaceutics)
    Dadhichi College of Pharmacy, BPUT, Orissa
    deepjyoti987@gmail.com

    Abstract:
    The aim of this reviewis to introduce the basic principles of drug targeting as they have evolved over previous decades. The most important chemical features and biological behavioural characteristics of the carrier molecules exploited for drug targeting purposes will be addressed. Furthermore, a selection of drug targeting preparations that are either in the stage of clinical testing or have been approved for application in the clinic is discussed. As the basis of drug development lies in the understanding of the molecular basis of diseases, selective interference with regulatory processes in health and disease by drug targeting will become a powerful technology. Drug targeting can, in this respect, serve both as a therapeutic approach and as a research tool in unravelling the functions of these processes in normal physiology and under patho-physiological conditions.

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  • OXAZOLE – ISOXAZOLE: MOLECULE OF DIVERSE BIOLOGICAL ACTIVITIES

    About Authors:
    *C.P.Meher,  S.P.Sethy,  S. M Ahmed
    Department of pharmaceutical Chemistry, Maheshwara college of Pharmacy,
    chitkul (V), Isnapur “X” Road,  patancheru, Hyderabad.
    *chaitanyameher84@gmail.com

    ABSTRACT:-
    Heterocyclic chemistry is vastly expanding because of the enormous amount of research work being done in this area. Heterocyclic compound are very widely distributed in nature and are particularly important because of the wide variety of physiological activities associated with this class of substances . A great deal of research is carried out to prepare new heterocyclic molecules having therapeutic uses.[1] and also so many heterocyclic derivative are synthesized till now having desired pharmacological effect. Out of them oxazole & isoxazole derivatives are catagorised in a higher position as the other heterocyclic compound possess in the hetero-chemistry. The present review is concern with the comparative study of the derivative of oxazole & isoxazole derivatives  along with their pharmacological effects.

  • BOTULINUM TOXIN TYPE A TREATMENT FOR COSMETIC AND MEDICINAL USE

    About Authors:
    *Lavkesh A.Chandivade,  Vishal V.Bandre,  Nilesh M. Choudhary
    Viva Institute of Pharmacy
    Shirgaon ,Virar(E)
    *lavkeshc@gmail.com

    ABSTRACT:
    BOTULINUM TOXIN is a neurotoxin that is made of a complex mixture of proteins containing botulinum neurotoxin and various non-toxic proteins.
    The neurotoxin clostridium botulinum is a spore-forming gram positive anaerobic bacterium that is made up of light chain and a heavy chain linked by single disulphide bond. The non-toxic proteins include haemagglutinating proteins. The bacteria are considered harmful and life threatening and can lead to muscle paralysis or weakness. However Botulin toxin treatment is quite safe especially when used in small doses and injected directly to a specific area.

  • APPLICATION OF LC-MS

    About Authors:
    Jatin  Patel1*, Prof. Rajesh Kumar Dholpuria2, Dhiren Shah1
    2(Professor, Head of Department of pharmacognosy),
    1Seth G.L. Bihani S.D. College of Technical Education,
    Institute of Pharmaceutical Sciences and Drug Research,
    Sri Ganganagar, Rajasthan, INDIA
    *Patelj313@yahoo.com

    ABSTRACT:
    Liquid chromatography is a fundamental separation technique in the life sciences and related fields of chemistry. Unlike gas chromatography, which is unsuitable for nonvolatile and thermally fragile molecules, liquid chromatography can safely separate a very wide range of organic compounds, from small-molecule drug metabolites to peptides and proteins. Traditional detectors for liquid chromatography include refractive index, electrochemical, fluorescence, and ultraviolet-visible (UV-Vis) detectors. Some of these generate two- dimensional data; that is, data representing signal strength as a function of time. Others, including fluorescence and diode- array UV-Vis detectors, generate three-dimensional data. Three-dimensional data include not only signal strength but spectral data for each point in time. Mass spectrometers also generate three- dimensional data. In addition to signal strength, they generate mass spectral data that can provide valuable information about the molecular weight, structure, identity, quantity, and purity of a sample. Mass spectral data add specificity that increases confidence in the results of both qualitative and quantitative analyses. For most compounds, a mass spectrometer is more sensitive and far more specific than all other LC detectors. It can analyze compounds that lack a suitable chromophore. It can also identify components in unresolved chromatographic peaks, reducing the need for perfect chromatography. Mass spectral data complements data from other LC detectors. While two compounds may have similar UV spectra or similar mass spectra, it is uncommon for them to have both. The two orthogonal sets of data can be used to confidently identify, confirm, and quantify compounds.

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