Transdermal Drug Delivery System- A Total View

About Authors:
Vinay Mishra, Shilpi Bhargava
Advance Institute of Biotech and Paramedical Sciences,

Delivering medicine to the general circulation through the skin is seen as a desirable alternative to taking it by mouth. Patientsoften forget to take their medicine, and even the most faithfullycompliant get tired of swallowing pills, especially if theymust take several each day. Additionally, bypassing the gastrointestinal(GI) tract would obviate the GI irritation that frequently occursand avoid partial first-pass inactivation by the liver. Further,steady absorption of drug over hours or days is usually preferableto the blood level spikes and troughs produced by oral dosageforms.1

From 1979, when the Food and Drug Administration approved the first transdermal drug delivery system (Transderm Scop® Patch), to the current transdermal delivery systems, there evolved a successful alternative to systemic drug delivery. Despite their relatively higher costs, transdermal delivery systems have proved advantageous for delivery of selected drugs, such as estrogens, testosterone, clonidine, nitroglycerin, scopolamine, fentanyl, and nicotine.
Transdermal therapeutic systems are defined as self contained, discrete dosages forms which when applied to the intact skin, deliver the drug, through the skin, at a controlled rate to the systemic circulation.Transdermal drug delivery systems, where applicable, offer several advantages over other conventional dosage forms.2