HERBAL REMEDIES USED IN THE TREATMENT OF EPILEPSY

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ABOUT AUTHORS:
Sachchidanand Pathak*, L Singh, T Singh, S K Sharma
Sunder Deep Pharmacy College,
Ghaziabad, Uttar Pradesh, India
sachchidanand.pathak904@gmail.com

ABSTRACT
This article has been made to review of following plants used for the antiepileptic activity. The plant sources of India are likely to provide effective antiepileptic agents. Herbs have a vital role in the prevention and treatment of convulsion. The phytochemical exploration of these herbs has contributed to some extent in this race for the discovery of new antiepileptic drugs (AED). In recent years owing to the fear of side effects people prefer more and more use of natural plant products for convulsions. This review also helps to summarize the diverse methodologies and ways to evaluate the potential natural compounds having antiepileptic activity.

Convulsion is the second most common neurologic disorder after stroke. Approximately 1% of the world’s population has convulsion, it is a condition where the patient suffers from recurrent seizures. Control to seizures numerous conventional drugs came into existence. Most of the epileptic patients need polytherapy of conventional anticonvulsants and still not 100% cured.

The major drawback due to these agents is their chronic side effects and drug interactions which restrict its use. On the other hand nature has provided us plants to be used as natural remedy for diseases with least side effects and insignificant drug interactions. This has motivated the researchers towards herbal remedy for anticonvulsant activity. In this review, herbal drugs have been discussed with more emphasis on the research advancements of traditional or herbal anticonvulsants.


REFERENCE ID: PHARMATUTOR-ART-1879

INTRODUCTION- 
The herbal medicines principles are relatively simple, although they are quite distinct from conventional medicine. India is a rich source of medicinal plants and a number of plant extracts are used against diseases in various systems of medicine such as Ayurveda, Unani and Siddha. Only a few of them have been scientifically explored.[1] Searching the plant kingdom for a treatment or cure for convulsions[2] or seizures is not an unreasonable approach to the problem particularly, when one considers that no pharmacological prototype has been found outside either the plant or animal kingdom. The history of herbal treatments for convulsion is coincidental with the history of medicine as well as history of civilization itself.[3]

The term epilepsy is collectively designated for a group of chronic central nervous system (CNS) disorder (neurological disorder) characterized by spontaneous occurrence of seizures generally associated with the loss of consciousness and body movements (convulsion)[4], there annual incidence of 50/100,000 per year.[5] Epilepsy is defined as recurrent seizures that are not the immediate result of an acute cerebral insult.[6]


ANTIEPILEPTIC PLANTS-
Traditional herbs are very useful and indispensable in the struggle for seizure management and future AED development. Therefore alternative therapy including herbal drugs and complementary medicine is becoming increasing popular.[7]

There are a new plant which are Datura metel Linn(Solanaceae) which are used in traditional medicine for several years to treat epilepsy and other problems. Medicinal plants have contributed a rich health to human beings. Plant extracts and their bioactive compounds present in them which are responsible for antiepileptic activity have to be screened for their valuable information. Rather than using a whole plant, pharmacologists identify, isolate, extract, and synthesize individual components, thus capturing the active properties or constituents.Herbal medicines are very cheap in comparison to the conventional form of medication. It’s something which every pocket can afford, unlike other forms of medication which can create a big hole in your wallet. One of the greatest benefits associated with herbal medicine is the non existence of side effects. Although herbal medicines has the potential to cure many ailments, the curing period is usually longer in comparison to conventional medication.[8]

In Africa and in Cameroon particularly, phytotherapy in traditional medicine still plays an important role in the management of diseases, mainly among populations with very low income (Geoffrey & Kirby, 1996) and phytotherapy relies on the use of a wide variety of plant species. These plants shows antiepileptic activity, Ricinus communis Linn (Euphorbiaceae), Citrus sinenis (Linn), Osbeck (Rutaceae) and several other plants which are described below.[9]

S.N.

Medicinal Plant

Family

Chemical Constituents

Parts

Used

1.

Cannabis sativa

Urticaceae

Cannabinoids

Leaves

Anticonvulsant

2.

Canscora decussata

Gentianaceae

1,3,5-tri and 1,3,5,6,7-penta-oxy--xanthones

Entire plant

Anticonvulsant

3.

Cinchona officinalis

Rubiaceae

Quinine

Bark, root

Anticonvulsant

4.

Magnolia officinalis

Magnoliaceae

Magnold and honokiol

Bark

Anticonvulsant

5.

Nardostachys jatamansi

Valerianaceae

Jatamansinone

Root, rhizome

Anticonvulsant

6.

Panax ginseng

Araliaceae

Saponins

Root

Anticonvulsant

7.

Rauwolfia serpentine

Apocynaceae

Reserpine

Whole herbs

Anticonvulsant

8.

Valeriana officinalis

Valerianaceae

Valepotriates, valtrate, valeridine, valechlorine

Roots

Anticonvulsant

9.

Ergot (Cleviceps perpurea)

Clavicipitaceae

Ergot alkaloids, ergotamine, bromocriptine

Ergot Extract

Anticonvulsant

The alternative drug therapy for the management of this disease can be by the use of medicinal plants and their active principles. In the present study, plants from India with a traditional claim of anti epileptic activity and neuroprotective properties has been selected and a Datura metel extract is prepared in different medium.[10]

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