You are hereEffect of Oscimum Basilicum on Formulation and Evaluation of Rapid Disintegrating Tablet of Lamotrigine

Effect of Oscimum Basilicum on Formulation and Evaluation of Rapid Disintegrating Tablet of Lamotrigine


About Authors:
SHARMA AKANSHA*, AGRAWAL SHIKHA

SWAMI VIVEKANAND COLLEGE OF PHARMACY
KHANDWA ROAD INDORE (M.P.)
*akansha.sharma@mylan.in

ABSTRACT :
The main aim for performing this project is to increase the bioavailabilty of lamotrigine as well as its onset of action to control the seizures that occur during the epileptic attack. To serve this purpose we will use mucilage of oscimum basilicum as a natural superdisintegrant & later comparing it with different novel synthetic superdisintegrant. By preparing a rapid disintegrating tablet of lamotrigine, rapid action of same can be achieved easily.
As we know that superdisintegrant plays the major role in rapid disintegration of tablet, thus it is very important to select a right or correct superdisintegrant in all respect which fulfill its purpose without effecting other parameters of tablet formulation and gives quicker and better result, when the number of formulation with different combinations of superdisintegrants (Natural & Synthetic) will be made then it would become very easy to evaluate and get the formulation with maximum desirable results.Lamotrigine being a poorly water soluble drug, needs modification to make them water soluble.

Reference Id: PHARMATUTOR-ART-1347

INTRODUCTION :
Rapid Disintegrating Tablets are solid dosage forms containing medicinal substances which disintegrate rapidly, usually in a matter of seconds, when placed on the tongue. Many pharmaceutical dosages are administered in the form of pills, granules, powders, and liquids. Generally, a pill design is for swallowing intact or chewing to deliver a precise dosage of medication to patients. The pills, which include tablets and capsules, are able to retain their shapes under Moderate pressure. However, some patients, particularly pediatric and geriatric patients, have difficulty swallowing or chewing solid dosage forms. Many pediatric and geriatric patients are unwilling to take these solid preparations due to a fear of choking. In order to assist these patients, several fast-dissolving drug delivery systems have been developed.
Fast-dissolving drug delivery in recent years, a variety of improved methods for delivering drugs has been developed with the aim of improving performance, convenience and compliance. Rapid Disintegrating Tablets disintegrate and or dissolve rapidly in the saliva without the need for water. Some tablets are designed to dissolve in saliva remarkably fast, within a few seconds, and are true fast-dissolving tablets. Others contain agents to enhance the rate of tablet disintegration in the oral cavity, and are more appropriately termed fast-disintegrating tablets, as they may take up to a minute to completely disintegrate. When put on tongue, this tablet disintegrates instantaneously, releasing the drug, which dissolves or disperses in the saliva. Some drugs are absorbed from the mouth, pharynx and oesophagus as the saliva passes down into the stomach. In such cases, bioavailability of drug is significantly greater than those observed from conventional tablet dosage form. The advantage of orally disintegrating dosage Forms are increasingly being recognized in both industry and academia.
Rapid Disintegrating Tablets, as a novel dosage form, have several characteristics to distinguish them from the more traditional dosage forms. Taste-masking is of critical importance in the formulation of an acceptable RAPID DISINTEGRATING TABLETS. Traditional tablet formulations generally do not address the issue of taste masking, because it is assumed that the dosage form will not dissolve until passing the oral cavity.

List of RAPID DISINTEGRATING TABLETS of LAMOTRIGINE Available in the Market

S.No.

Brand Name

API (in mgs)

Manufactured by

1

Lamepil

Lamotrigine (25, 50, 100)

Innova (Ipca)

2

Lemetec

Lamotrigine (5, 25, 50, 100)

Protec (Cipla)

3

Lamidus

Lamotrigine (25, 50, 100)

Zydus Neuro

4

Lamitor-DT

Lamotrigine (25, 50, 100)

Mind(Torrent)

5

Lyzin

Lamotrigine (25, 50, 100)

Pifer

6

Lametec DT

Lamotrigine (5, 25, 50, 100)

Protec (Cipla)

7

Lamidus Dispertab

Lamotrigine (25, 50, 100)

Zydus Neuro

8

Lamictal

Lamotrigine (5, 25, 50, 100)

GSK

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