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Sweety Sharma*, Amardeep Ankalgi, Chandra Shekhar Sharma, Hemendra Pratap Singh, Priyadarshani Kamble, Mahendra Singh Ranawat.
Deptt. Of Pharmaceutical Chemistry, B.N.College of Pharmacy,
Udaipur-313002, Rajasthan, India.
Impurity is defined as any substance coexisting with the original drug, such as starting material or intermediates or that is formed, due to any side reactions. According to the International Conference on Harmonization of Technical Requirements for the Registration of Pharmaceuticals for Human Use (ICH) guideline on impurities in new drug substances, an impurity is defined as 'any component of the new drug substance that is not the chemical entity defined as the new drug substance’.Identification of impurities is done by variety of Chromatographic and Spectroscopic techniques, either alone or in combination with other techniques. There are different methods for detecting and characterizing impurities with TLC, HPLC, and HPTLC etc. The most exploited techniques, for impurity profiling of drugs are LC-MS-MS, LC-NMR, LCNMR- MS, GC-MS, and LC-MS.
Chaitanya Prasad Meher*2 , M.V.Kumar1, V.Sravanthi1 , K.Ramya1, K.Satyanarayana1
1Maheshwara College of Pharmacy, Chitkul, Isnapur,
Patancheru, Hyderabad-502307 (A.P)
2Assistant professor, Department of pharmaceutical chemistry,
Maheshwara College of Pharmacy, Hyderabad-502307 (Andhra Pradesh)
Neuroscience is a broad, multidisciplinary field concerned with the nervous system, its components, and functional activities, including behavior and consciousness. It relates to nerve cells function and development, how do they communicate, how do brains work, and how have they evolved, Nature of consciousness, and the neural basis for behaviors and for human brain dysfunction. These are among the many questions being answered by contemporary neuroscience. The present review article is concern on the aspect that usually reated to the neurochemistry.
*M.C.Sai HariKishan, C.P.Meher, S.M.Ahmed
Maheshwara Institute Of Pharmacy, Chitkul, Isnapur ,
Sunscreen agents are used to prevent sunburn. Limiting the exposure to the sun and using sunscreen agents when in the sun may help prevent early wrinkling of the skin and skin cancer. There are two kinds of sunscreen agents: chemical and physical. Chemical sunscreen agents protect from the sun by absorbing the ultraviolet (UV) and visible sun rays, while physical sunscreen agents reflect, scatter, absorb, or block these rays. Sunscreen agents often contain more than one ingredient. For example, products may contain one ingredient that provides protection against the ultraviolet A (UVA) sun rays and another ingredient that protects from the ultraviolet B (UVB) sun rays, which are more likely to cause sunburn than the UVA sun rays. Ideally, coverage should include protection against both UVA and UVB sun rays. The sun protection factor (SPF) that find on the label of these products tells the minimum amount of UVB sunlight that is needed with that product to produce redness on sunscreen-protected skin as compared with unprotected skin. Sunscreen products with high SPFs will provide more protection against the sun.The presented review article is concern with discussion on the sunscreen agents.
M.pharm Lord Shiva College of pharmacy Sirsa
Teaching Assistant Dept of Pharm. Edu. and research, Bhainswal Kalan
Asymmetric hydrogenation is by far the most attractive form of stereoselective synthesis. Using optically pure catalysts, prochiral substrates can be converted to chiral compounds with high selectivity. These catalysts can be completely organic in nature (for example proline 50) or contain a transition metal which coordinates to an organic chiral ligand. In the last decades, considerable progress has been made in the development of metal catalyzed asymmetric transformation based on enantiopure ligands complexed to a transition metal core. However, the identification of suitable asymmetric catalysts still poses one of the most challenging endeavours in contemptory chemistry.
Swathi.Pathi*, Swarna Latha.D, M.Sreenivasulu.
Department of Pharmaceutical Chemistry,
Annamcharya college of pharmacy, newboyana pally, rajampet(M),
kadapa(dt). Andhara Pradesh, India.
A heterocyclic compound is one which possesses a cyclic structure with at least two different kinds of hetero atoms in the ring. Heterocyclic compounds are very widely distributed in nature and are essential to life in various ways1.
The chemistry and biological study of heterocyclic compounds has been an interesting field for a long time in medicinal chemistry. A number of heterocyclic derivatives containing nitrogen and sulphur atom serve as a unique and versatile scaffolds for experimental drug design2.
Benzothiazole is one of the most important heterocyclic compound, weak base, having varied biological activities and still of great scientific interest now a days. They are widely found in bioorganic and medicinal chemistry with application in drug discovery.
SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF SOME CALCIUM CHANNEL BLOCKER THIOSALICYLAMIDE DERIVATIVES AS ANTIHYPERTENSIVE AGENTS
ABHISHAK SINGH PARMAR,
M.PHARMACY (MEDICINAL AND PHARMACEUTICAL CHEMISTRY),
B.R.NAHATA COLLEGE OF PHARMACY,
1.1 Medicinal and Pharmaceutical chemistry
It is a discipline at the intersection of chemistry and pharmacology involved with designing, synthesizing and developing pharmaceutical drugs. Medicinal chemistry involves the identification, synthesis and development of new chemical entities suitable for therapeutic use. It also includes the study of existing drugs, their biological properties, and their quantitative structure-activity relationships (QSAR). Pharmaceutical chemistry is focused on quality aspects of medicines and aims to assure fitness for the purpose of medicinal products. Compounds used as medicines are overwhelmingly organic compounds including small organic molecules and biopolymers. However, inorganic compounds and metal-containing compounds have been found to be useful as drugs. For example, the cis-platin series of platinum-containing complexes have found use as anti-cancer agents.1
Shaishavi Parikh*, Arun Parikh, Vijayalakshmi Gudaparthy
Department of pharmaceutical chemistry, L. J. Institute of Pharmacy,
Thiazolo[3,2-a]pyrimidine were synthesized by the reaction of the indole aldehyde with thiourea and methyl isobuterylacetate to generate thioxo pyrimidine compound which condensed to phenacyl bromide to form thiazolo[3,2-a]pyrimidine. All synthesized compounds are characterized by the IR, Mass and NMR spectroscopy and evaluated for the antibacterial and anti fungal activity by using B. cereus, S. aureus strains of Gram positiveE. coli strain of Gram negative andC.albicans strain of fungus. The compound having nitro and methoxy substituent shows significant activity in thiazolo[3,2-a]pyrimidine derivatives.
Ravindra Singh Tomar
M.Pharm (Medicinal & Pharmaceutical Chemistry),
B R Nahta College of Pharmacy, Mandsaur (M.P)
Here a scheme has been designed for synthesis of 2-chloropyridine-5-trifluoromethyl derivatives. The probability of being antiamnesic agent has been checked by pass prediction. All compound shows antiamnesic activity as result of pass prediction. By Lipinski rule of five all compounds shows drug like activity. Also a method for pharmacological evaluation & Biochemical evaluation is described under. All synthetic procedure has been designed & described under-
SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NOVEL 3-(2-(1H-INDOL-2-YL) PHENYL)-2-ARYLIMIDAZO[4,5-b]INDOLES
Aditya Dixit1, Gyanendra Kumar Sharma2, Devender Pathak*3
1M. Pharmacy (Pharmaceutical Chemistry)
2Associate Professor (Pharmaceutical chemistry)
3Director, Professor and Head of the Dept. (Pharmaceutical Chemistry)
Rajiv Academy for Pharmacy, Mathura,
Delhi-Mathura Highway, Chhattikara, 281006, India
A traditional but effective method of developing new targets is lead molecule modification, where an existing popular drug from the market is taken as a lead and similar derivatives are synthesized. With the advent of modern techniques conventional methods have lost their gleam but, reactions are still best understood when performed by the conventional techniques. One such endeavor has been made here where indole has been used as a parent moiety and by adding some functional groups some novel indole derivatives were synthesized and screened for their in vitro antitubercular, and anticancer activity. This synthesis of some fresh indole derivatives was done by using various benzaldehyde derivatives and 2-(o-Aminophenyl)indole in acidic condition then with ammonium acetate and isatin in presence of glacial acetic acid.. The structures of newly synthesized compounds were characterized by IR, 1H NMR, MASS and elemental analysis.Compounds 3h & 3i showed good antitubercular activity and 3d, 3e & 3g showed good anticancer compared to the standard drug.
Zubair Khalid Labu1; AK Mohiuddin1; M.A Bake*2
1Department of Pharmacy, World University of Bangladesh (WUB), Dhaka-1215, Bangladesh
*2Product Development officer, Gonoshasthaya Pharmaceuticals Ltd., Mirzanagar, Savar, Dhaka-1344.
Food is the major source of energy in humans as well as animals. Foods are materials taken into the body by different route which provide nourishment in the form of energy or in the building of tissues. Food contaminants are substances that make food unfit for human consumption. Examples include bacteria, toxic chemicals, carcinogens, teratogens and radioactive materials. The purpose of these studies is to find out the food contaminants which are used in different purposes available in Bangladesh and contaminants detection method. After survey we found that Dhaka is the main city where food contamination by various contaminants in higher percentage. This contamination done by manmade, industrial discharge, poisonous water etc. Government of Bangladesh taking various necessary steps to stop this contamination.
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