July 2012

About authors:
Gourab Saha^*1, Pankaja Senapati¹, Narahari Sahu², Dr. Sambit Parida³
1. Department of Pharmaceutics, College of Pharmaceutical Sciences, Mohuda, Berhampur – 2, Orissa, India.
2. Department of Pharmacology, College of Pharmaceutical Sciences, Mohuda, Berhampur – 2, Orissa, India.
3. Department of Pharma analysis, College of Pharmaceutical Sciences, Mohuda, Berhampur–2, Orissa, India.
*gourab.pharma2012@gmail.com

Abstract
This study investigated the anti-inflammatory activity of the methanolic extract of Cissampelos pareira (Abuta) in male albino rats after intramuscular administration. This was done using the carragenin-induced paw edema method. Methanolic extract of Cissampelos pareira showed significant anti-inflammatory activity similar to ibuprofen and indomethacin.

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The Virus Research Center (VRC), Pune came into existence in 1952 under the joint auspices of the ICMR and the Rockefeller Foundation, as a part of the global programme of investigations on the arthropod-borne group of viruses. In view of its expanded scope and activities, the VRC was redesignated as the National Institute of Virology (NIV) in 1978.

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About Authors:
Chauhan M.K., Kawadkar J., Kishore R.^*, Pathak A.M.
Department of Pharmaceutics
DIPSAR, New Delhi
*rajkishor.aryan@gmail.com

ABSTRACT
This paper discussed the problems associated with nasal drug delivery and how it is possible, sometimes by means of quite simple concepts, to improve transport across the nasal membrane. It also described the advantages, barriers, physicochemical factors, and formulation related parameters that affecting the nasal drug delivery and the applications of nasal route for delivery of peptides, proteins, non-peptide drugs, and vaccines.  In this way it is feasible to deliver efficiently challenging drugs such as small polar molecules, peptides and proteins and even the large proteins and polysaccharides used in vaccines or DNA plasmids exploited for DNA vaccines. The transport of drugs from the nasal cavity directly to the brain is also described. Nasal vaccines offer several benefits, such as low enzymatic degradation compared to oral vaccines, and greater acceptability to patients. Nasal vaccines, however, have to overcome several limitations, including mucociliary clearance. Therefore, nasal vaccines require potent adjuvants and delivery systems to enhance their immunogenicity and to protect their antigens.

Sinhgad Institute Of Pharmaceutical Sciences is affiliated to University of Pune and approved by All India Council for Technical Education, Pharmacy Council of India, Director of Technical Education, Mumbai, Maharashtra State. It offers undergraduate and postgraduate courses in Pharmacy.

Post: Professor, Associate Professor, Assistant Professor

The Department of Biotechnology (DBT), Govt. of India has initiated a multi-institutional partnership program on biodesign called the National Bio design Alliance Programme between Translational Health Science & Technology Institute (THSTI), Regional Centre for Biotechnology (RCB), International Centre for Genetic Engineering and Biotechnology ( ICGEB), All India Institute of Medical Sciences (AIIMS), Indian Institute of Technology (IIT) Delhi and Christian Medical College (CMC) Vellore.