A.R. College of Pharmacy and G.H. Patel Institute of Pharmacy

DRUGS AND INTELLECTUAL PROPERTY RIGHTS: POSITIVE AND NEGATIVE ASPECTS

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ABOUT AUTHORS
J A Sathwara1, A M Bhandari2
1* Department of Pharmacology, A.R.College of Pharmacy & G.H.Patel Institute of Pharmacy, Anand ,Gujarat
2 Department of Clinical Pharmacy, A.R.College of Pharmacy & G.H.Patel Institute of Pharmacy, Anand ,Gujarat

*jignasa.sathwara@gmail.com

ABSTRACT
The development of drugs is costly for the Pharmaceutical companies and without the protection of Intellectual Properties, the formula for the drug can easily be duplicated and can be synthesized at cheaper cost. The U.S. intellectual property laws protect the rights of small inventors and large corporations alike to guarantee “the first to invent” the exclusive right to the patents. To solve the drug price inflation within the U.S., an initiative has been taken that drug patents are different from other innovations. Under the new plan, new drugs would be sold at generic prices upon FDA’s approval. New drugs will no longer be rewarded by net-profit from sales, but instead by Medical Innovation Prize Fund at a level of 0.5% of the gross domestic product, that provide money to developers of new products based upon the actual impact on health outcomes over ten years. Although patents protect the rights of the investors and courage innovations, there are certain ideas that should not been patented. Potentially lifesaving technologies should be separated from other type of innovations, and money making should not be the only inceptive for drug discovery. The number of worldwide who have access to medicines is low, an allowing patents on drugs, although increase the number of advancements in lifesaving technologies; it will decrease the number of people who access to them. International efforts should focus on allocating monetary motivation to provide people to access drugs.

ANTIEPILEPTIC ACTIVITY OF MURRAYA KOENIGII LEAF EXTRACTS

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ABOUT AUTHORS
JA Sathwara1*, AM Bhandari2
1Department of Pharmacology,
A.R.College of Pharmacy & G.H.Patel Institute of Pharmacy, V.V. Nagar, Anand, Gujarat.
2Department of Clinical Pharmacy,
A.R.College of Pharmacy & G.H.Patel Institute of Pharmacy, V.V. Nagar, Anand, Gujarat.

*jignasa.sathwara@gmail.com

ABSTRACT
The aim of the present study was to investigate antiepileptic effect of the aqueous extract of the leaves of Murraya koenigii L. Spreng (AEMK) on electrically and chemically induced seizures. The aqueous extract of the leaves of M. koenigii (200 and 300 mg/kg) were studied for its antiepileptic effect on maximal electroshock induced seizures and pentylenetetrazole induced seizures in mice. AEMK (200 and 300 mg/kg) significantly reduced the duration of seizures induced by maximal electroshock (MES) as well as protected animals from pentylenetetrazole induced tonic seizures. The results suggest that the aqeous extract of the leaves of M. koenigii may produce its antiepileptic effects via non-specific mechanisms since it reduced the duration of seizures produced by maximal electroshock as well as delayed the latency of seizures produced by pentylenetetrazole.

GUJCOST & DST SPONSORED NATIONAL WORKSHOP ON “ANIMAL HANDLING AND DOSING TECHNIQUES IN PRECLINICAL STUDIES FOR DRUG RESEARCH” A. R. College of Pharmacy & G. H. Patel Institute of Pharmacy

A. R. College of Pharmacy & G. H. Patel Institute of Pharmacy (ARGH) is one of the best Pharmacy Institutes in the Gujarat region. CVM set up an institute offering D. Pharmacy in the year 1981, with generous donation from eminent philanthropist Shri Gordhanbhai Hathibhai Patel & in the very next year i.e 1982 established with donation from an industrialist Smt. Anjanaben Ashokbhai Shah.

GUJCOST & DST Sponsored National Workshop on "Animal Handling and Dosing Techniques in Preclinical Studies for Drug Research" at A.R. College of Pharmacy & G. H. Patel Institute of Pharmacy

A.R. College of Pharmacy & G. H. Patel Institute of Pharmacy (ARGH) is one of the best Pharmacy Institutes in the Gujarat region. CVM set up an institute offering D. Pharmacy in the year 1981, with generous donation from eminent philanthropist Shri Gordhanbhai Hathibhai  Patel & in the very next year i.e 1982 established with donation from an industrialist Smt. Anjanaben Ashokbhai Shah.

A COMPARATIVE STUDY FOR SAFETY AND EFFICACY OF OXACEPROL AND DIACEREIN IN OSTEOARTHRITIS OF KNEE JOINTS

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ABOUT AUTHOR:
Jay Shah1, Nazima Mirza2, Vivek Patel3
1Department of Clinical Pharmacy, A.R.College of Pharmacy and G.H.Patel Institute of Pharmacy,
Vallabh Vidyanagar, Gujarat, India.
2Department of Pharmacology, Pramukh Swami Medical College, Karamsad, Gujarat
3Department of Orthopedic, Shree Krishna Hospital, Karamsad, Gujarat
shahjayg@yahoo.com

ABSTRACT
Objectives: Osteoarthritis (OA) is the most common form of arthritis which has a growing number of patients and having major impact on the quality of life. According to modes of action the drugs for OA are divided into two groups. First group, NSAIDs which provide symptomatic relief but have no influence on progress of the disease and shows higher adverse events. The second group of drugs acts as disease modifying agents. Recent data from clinical trials have demonstrated that agents like Diacerein & Oxaceprol specifically block key disease mechanisms & effectively retard the progression of structural changes in knee OA patients. The study was undertaken to compare the efficacy & safety of Oxaceprol and Diacerein in the patients of Osteoarthritis of Knee joints.
Experimental/ Computational work done: Total 60 patients(4 withdrawn) suffering from mild to moderate OA of knee joint were included from outpatient orthopedic department of Shree Krishna hospital, Karamsad. Twenty eight patients received diecerein(50 mg b.i.d.) and 28 patients were given Oxaceprol(200 mg t.i.d.)  for 10 days and patient responses were measured using VAS and Lequesne scale, before and after drug treatment. Suspected adverse event was evaluated by filling ADR form. Ethical committee approval and patient consents were obtained prior to the beginning of the study.
Results and discussion: The VAS Scale was reduced from 7.321 ± 0.9449 to 4.75 ± 1.146 (Mean±SD) for Diacerein and 6.821 ±1.1564 to 4.321±1.1564 for Oxaceprol. The Lequesne scale was reduced from 6.0±1.054 to 4.21±1.0923 for Diacereine and 6.0±0.8819 to 3.839±1.0475 for Oxaceprol. Both the results were found to be statistically significant. Difference in VAS and Lequesne scale between the Diacerein and Oxaceprol were 0.757 and 0.099 respectively (p >0.05). There was not any Adverse Event reported.
Conclusions: Both the drugs, Diacerein and Oxaceprol, individually and equally effective in Osteoarthritis condition. Both Diacerein and Oxaceprol are found to be safer.

Applications are invited for Research Fellow/Project Assistant position in A.R.College of Pharmacy & G. H. Patel Institute of Pharmacy

Applications are invited for one Research Fellow/Project Assistant position in a SERB, DST sponsored research project entitled 'Comparative evaluation of pharmacokinetic parameters & brain targeting efficiency of antipsychotic drug loaded nano-emulsion following intranasal and intravenous administration' (SR/FT/LS-135/2012 dated 11th January, 2013.)

Post: Research Fellow/Project Assistant