Lachoo Memorial College of Science and Technology

AN INSIGHT ON NUTRACEUTICALS

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ABOUT AUTHORS:
Niyati Borkar*1, SS Saurabh2, KS Rathore3, Ashlesha Pandit1, KR Khandelwal1
1JSPM’s Rajarshi Shahu College of Pharmacy and Research, Tathwade, Pune, India
2Lachoo Memorial College of Science & Technology, Pharmacy Wing, Jodhpur (Raj.), India
3BN Institute of Pharmaceutical Sciences, Udaipur (Raj.), India
niyatiborkar@yahoo.in

ABSTRACT
The concept of nutraceutical a evidence based medicines was started from a survey held in United Kingdom, Germany and France which concluded that diet is rated more highly by consumers than exercise or hereditary factors for achieving good health. Nutraceutical, a portmanteau of the words “nutrition” and “pharmaceutical”, is a food or food product that reportedly provides health and medical benefits, including the prevention and treatment of disease. Nutraceutical is a term that does not easily fall into the legal category of food and drug and often inhabits a grey area between the two. Nutraceuticals may range from isolated nutrients herbal products, dietary supplements and diets to genetically engineered “designs” foods and processed products such as cereals, soups and beverages and hence also referred to as functional foods. A nutraceutical is demonstrated to have a physiological benefit or provide protection against chronic disease. Apart from disease prevention, they play an important role in disease management and therapy. Also, the growing consumer awareness regarding health care has led to the tantalizing opportunity for a “nutraceutical” breakthough in the pharmaceutical battleground as an alternative to modern medicine. This revolution will lead us into a new era of medicine and health, in which the food industry will become a research oriented one similar to the pharmaceutical industry. This review article focuses on the definition, history, development, classification, challenges and opportunities, regulations,global market scenario as also the motivation behind the development of nutraceuticals.

ENGINEERED NANOCARRIERS: AN EMERGING TOOL IN THERAPEUTICS AND DIAGNOSTICS

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ABOUT AUTHORS:
S. Chouhan*, P. Sharma, J. Pathak, A. Namdev, M. Sain
Lachoo Memorial College of Science and Technology,
Pharmacy wing; Jodhpur
shailendra.chouhan26@gmail.com

ABSTRACT
In present era nanoparticles have emerged as an efficient and promising tool in therapeutics and diagnostics. Nanotechnology is a multidisciplinary field it merges basic sciences and applied disciplines like biophysics, molecular biology and bioengineering. Nanotechnology has created impact in various fields of medicine comprising neurology, oncology, immunology, cardiology, endocrinology. Nanotechnology presents revolutionary opportunities for diagnosis and therapy of many diseases. The nanoparticles capable of diagnosis, drug delivery and monitoring of therapeutic response are expected to play a significant role in emergence of era of personalized medicine.

MICROSPHERES AS HYDRODYNAMICALLY BALANCE SYSTEM

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About Authors:
Rohit Kumar Ahuja*1, Surendra Singh Saurabh1, Poonam Choudhary1, Aniket Singh Chouhan1, Kamal Singh Rathore2
1 Lachoo Memorial College of Science and Technology (Pharmacy Wing) Sector-A, Shastrinagar, Jodhpur (Raj.) 342003, IND.
2 BN Institute of Pharmaceutical Sciences, Udaipur (Raj.) 313002, India
rohitahuja1111@gmail.com

Abstract:
To build up an oral drug delivery system, it is essential to optimize both release rate of drug and residence time of system within gastrointestinal tract. In oral path difference in gastric physiology such as gastric pH and motility display variability on gastric residence time (GRT) and drug delivery actions. Several approaches are currently utilized in the prolongation of the GRT including hydrodynamic balance systems (HBS), swelling and expanding systems, polymeric bioadhesive systems, high-density systems, modified-shape systems and other delayed gastric emptying devices.One such approach is Floating Microspheres (Hollow Microspheres). Floating microspheres are gastro-retentive drug delivery systems based on non-effervescent approach. These microspheres are characteristically free flowing powders made of proteins or synthetic polymers, ideally having a size less than 200 micrometer. Gastro-retentive floating microspheres are low-density systems that have sufficient buoyancy to float over gastric contents and remain in stomach for prolonged period. The drug is released slowly at desired rate resulting in increased gastric retention with reduced fluctuations in plasma drug concentration. Floating microspheres improve patient compliance by decreasing dosing frequency and better therapeutic effect of short half-life drugs can be achieved. Floating microspheres are characterized by their micromeritic properties such as particle size, tapped density, compressibility index, true density and flow properties including angle of repose, scanning electron microscopy, in vitro floatability studies, in vitro drug release studies and stability studies etc.

FORMULATION AND EVALUATION OF PHYTOSOMES LOADED WITH GENISTIN-SOYBEAN PHOSPHOLIPID COMPLEX DEVELOPED FOR DRUG DELIVERY

About Authors:
Aniket Singh*, Poonam Sain, Rekha Singh Saurabh1, Surendra Singh, Kamal Singh Rathore1
*Department of Pharmaceutics, Lachoo Memorial College of Science and Technology (Pharmacy Wing), Shastri Nagar, Jodhpur, 342003 (Raj.), INDIA.
1B.N. Institute of Pharmaceutical Sciences, Udaipur-Raj.313002 INDIA
aniketsingh18@yahoo.com

Abstract
Phytosomes of soy-isoflavones (genistin/daidzin) was formulated to provide good bioavailability for treatment of cancer associated with skin and prostate etc. There are many dosage forms like tablet, capsules, liposomes etc. of isoflavones having anticancer activity available in market but still need for a new dosage form which acts effectively with better bioavailable dose. So the present investigation has been taken up to design, prepare and evaluate phytosomes to meet need of bioavailability and local action. Benefits of this phytosomes showed increase in bioavailability, reduction in gastric irritation by passing first pass metabolism and increase onset of action. Phytosomes were prepared using lecithin as phospholipid and ethanol, acetone etc as solvent system. All formulations were subjected to physic-chemical evaluation. Selected were subjected to stability studies, spectroscopic and biological evaluations.

EMULGELS: A NOVEL APPROACH FOR TOPICAL DRUG DELIVERY OF HYDROPHOBIC DRUGS

About Authors:
Arpana Kumari*, Saurabh SS, Poonam K, Rathore KS1
*Department of Pharmaceutics, Lachoo Memorial College of Science and Technology, Pharmacy Wing,
Jodhpur, 342001 (Raj) India.
1BN Institute of Pharmaceutical Sciences, Udaipur-313002 (Raj.)
111arpnasingh@gmail.com

Abstract:
A unique aspect of dermatological pharmacology is the direct accessibility of the skin as a target organ for diagnosis and treatment. When gel and emulsion are used in combined form they are referred as Emulgel. Among the various groups of semisolid preparations, the use of gels has expanded both in cosmetics and in pharmaceutical preparations. Despite of several advantages of gels there is a limitation in delivery of hydrophobic drug moiety. This limitation can be overcome by the use of novel topical drug delivery i.e. emulgel. The major objective behind emulgel is delivery of hydrophobic drugs via skin. Emulgels show dual release control system i.e. gel and emulsion. The presence of a gelling agent in the water phase converts a classical emulsion into an emulgel. These emulgel are having major advantages on novel vesicular system as well as on conventional systems in various aspects. Emulgels have several favourable properties for dermatological use such as being thixotropic, greaseless, easily spreadable, easily removable, emollient, nonstaining, long shelf life, bio-friendly, transparent and pleasing appearance. So emulgels can be used as better topical drug delivery systems over present systems. The use of emulgels can be expanded in analgesics, anti-inflammatory, anti-fungal, anti-acne drugs and various cosmetic formulations.

BUCCOADHESIVE DRUG DELIVERY SYSTEM: A REVIEW

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About Authors:
Poonam K*, Saurabh SS, Arpana Kumari, Rathore KS1
*Department of Pharmaceutics, Lachoo Memorial College of Science and Technology, Pharmacy Wing, Jodhpur, 342001 (Raj) India.
1BN Institute of Pharmaceutical Sciences, Udaipur-313002 (Raj.)
poonam28nov.pharm@gmail.com

Abstract:
The main aim for the oral delivery of most of the drugs as potential therapeutic agents is their extensive presystemic metabolism, instability in acidic environment resulting into inadequate and erratic oral absorption. Parenteral route of administration is the only established route that overcomes all these drawbacks associated with these orally inefficient drugs. But these formulations are costly, have least patient compliance, require repeated administration, in addition to the other hazardous effects associated with this route. Buccal cavity was found to be the most convenient and easily accessible site for the delivery of therapeutic agents for both local and systemic delivery as retentive dosage forms. Buccoadhesive drug delivery is relatively new drug delivery strategy; in this traditional polymers are replaced by novel bioadhesive polymers such as Thiomers and lectins etc. to overcome limitation of traditional polymer. Buccoadhesive characteristic are factor of both bioadhesive polymer and the medium in which the polymer reside. It is the objective of this article to review buccoadhesive drug delivery by discussing the structure, permeability of buccal mucosa, mechanism of buccoadhesion, novel bioadhesive polymers, buccoadhesive dosage form and their evaluation, recent advances in buccoadhesive drug delivery system.

THERAPEUTIC POTENTIAL OF VENOMOUS PEPTIDE IN VARIOUS DISEASES

ABOUT AUTHORS:
1*Anjali Choba, 2Shikha Attri
1M.Pharma in pharmacology from shoolini university solan, himachal pradesh
2M.Pharm in pharmaceutical chemistry from lachoo memorial college of science and technology, jodhpur
*anji5057@yahoo.in

ABSTRACT
Venomous creatures have a sophisticated mechanism for prey capture which includes a vast array of biologically-active compounds, such as enzymes, proteins, peptides and small molecular weight compounds. The venom peptides are directed against a wide variety of pharmacological targets, making them an invaluable source of ligands for studying the properties of these targets in different experimental paradigms. Much knowledge has been gained in terms of how poisons and venoms and their composite toxins give rise to the syndromes associated with envenoming and poisoning and in some isolated cases there have been a few such agents promoted for therapeutic use. A number of these peptides have been used for the treatment of pain, diabetes, multiple sclerosis and cardiovascular diseases.

THALIDOMIDE AND ITS ANALOGUES IN ANTICANCER THERAPY

ABOUT AUTHORS:
Shikha Attri, Arti Choudhary, Devendra Gupta
M.Pharm in Pharmaceutical Chemistry, Lachoo
Memorial College of Science and Technology,
Jodhpur University, Rajasthan University Of Health Sciences, Jaipur
*shikhu921@gmail.com

ABSTRACT
Thalidomide, removed from clinical use because of severe teratogenicity, is back. In a comeback that has proceeded with remarkable speed, the drug that adversely affected more than 10,000 infants just over four decades ago now seems to be a lifesaver for patients with advanced plasma cell malignancies. Thalidomide and its immunomodulatory (IMiDs) analogs (lenalidomide, CC-4047, ACTIMID) are a novel class of compounds with numerous effects on the body’s immune system, some of which are thought to mediate the anticancer and anti- inflammatory results observed in humans. Thalidomide is currently being used experimentally to treat various cancers and inflammatory diseases. Immunomodulatory activities along with anti-angiogenic, anti-proliferative,and pro-apoptotic properties are thought to mediate the IMiDs’antitumor responses observed in relapsed and refractory multiple myeloma and some solid tumor cancers. This has led to their use in various oncology clinical trials.
A review is presented of the history of thalidomide and its analogues properties with an emphasis on applications in malignant disease.


COMPARATIVE STUDY OF DRUG PRODUCT RECALL REGULATIONS IN USA, UK AND AUSTRALIA AND DRAFT GUIDELINES FOR INDIA

About Authors: 
Bane Singh Rajput*
Research Scholar of Lachoo Memorial College of Science & Technology
Pharmacy Wing, Jodhpur (Raj.)
*bnsingh29@gmail.com

Abstract
Drug product recall is an action taken to withdraw or remove a batch or an entire production run of a drug product from distribution or use and return them to the manufacturer. It is usually done due to the discovery of deficiencies in quality, efficacy or safety in the marketed drug products. Defective drug products related to quality includes adulterated or spurious drugs. Safety and efficacy related recalls include serious adverse reactions and death. Recalls also include drugs prohibited under the law and also those products for which product licenses are suspended/ cancelled. In USA, guidelines for drug product recall are described under 21 CFR Parts 7, 107 and 1270.  In Australia, guidelines for drug product recall are described under section 65F of the Trade Practices Act 1974. Sections 2(2), 4, 5 and 7 of the European Communities Act 1972 and Directive 2001/95/EC on general product safety are followed in UK for drug product recall. In India, references for drug product recalls, complaint and adverse reactions are mentioned in Para 27, 28 of Schedule M and conditions of license for defective product recall in Rule 74(j) and Rule 78(i) of the Drugs and Cosmetics Act, 1940 and Rules there under. But no effective and uniform recall procedure and guidelines are formulated yet in India. This paper presents a comparative study of drug product recall guidelines in USA, UK and Australia. Based on this comparative study suggestions are provided to develop regulatory guidelines for drug product recall in India.

BUSINESS ETHICS: MANAGEMENT AND PHARMACEUTICAL INDUSTRY PERSPECTIVE

About Authors:
PANKAJ MUSYUNI*, PROF. (Dr.) B.P. NAGORI1, Mr. AKASH MIDHA2
*M. Pharm. (Pharma Management & Regulatory Affairs)
1 Director, Lachoo Memorial College of Science & Technology
2. Lecturer, Lachoo Memorial College of Science & Technology
Lachoo Memorial College of Science & Technology
‘Pharmacy Wing’, Jodhpur, Rajasthan
INDIA

ABSTRACT
Ethics can be explained as branch of philosophy related with the implication of all aspects of human behavior and nature. The purpose of this paper is to present an overview and relevance of business ethics in management and pharmaceutical industry scenario. The rationale of business can not be only illustrated by profit maximization but also by the social concern of the organization. This paper demonstrates the concept of business ethics with various attributes, factors and impact on society and also emphasize on code of ethics and its importance. Present paper also discusses common ethical problems within a pharmaceutical organization. A practical approach as case studies related to pharmaceutical industries will identify the issues and implications for ethical development, advancement and globalization of business ethics. Concept of paper focuses attention on the development of an attitude which should be adopted to understand various terms of ethics and development for social and business concern.

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