Avisek Mukhopadhyay*, Subhasis Banerjee
Gupta College Of Technological Sciences
M.Pharm(Bit Mesra, Ranchi)
Urbanization, industrialization, changes in lifestyles, population growth and ageing all have contributed for epidemiological transition in the country. The absolute number of new cancer cases is increasing rapidly, due to growth in size of the population, and increase in the proportion of elderly persons as a result of improved life expectancy following control of communicable diseases. In India, the life expectancy at birth has steadily risen from 45 years in 1971 to 62 years in 1991, indicating a shift in demographic profile. It is estimated that life expectancy of Indian population will increase to 70 years by 2021–25. Such changes in the age structure would automatically alter the disease pattern associated with ageing and increase the burden of problems such as cancer, cardiovascular and other non-communicable diseases in the society.The latest global figures show that in 2004, there were 11.4 million cases of cancer diagnosed worldwide, and 75% of these were in Europe, the Americas and the Western Pacific Region. The Western Pacific Region includes China, Malaysia, Japan, Australia and New Zealand. The lowest numbers of cases were diagnosed in the Eastern Mediterranean region (includes Saudi Arabia, Egypt Iraq, Morocco, Tunisia) and Africa.
There were differences in the top three most common cancers in each region. The top three included lung cancer in all regions except Africa and included breast cancer in all except for the Western Pacific region. Cervical cancer was in the top three in Africa and South-East Asia only and bowel cancer in the top three for Europe only. Prostate cancer was in the top three in Africa and the Americas.Let us discuss one of the most promising targets of these days, which when overexpressed may cause cancer, i.e.;HISTONE DEACETYLASE.