Orissa

About Authors:
Manoj Kumar Jadia^1*, U.L.Narayan^2
1 Department of Pharmaceutical Chemistry, Indira Gandhi Institute of Pharmaceautical Sciences, I.R.C. Village, Bhubaneswar, Dist:Khurda, Odhisa -751015
² Principal, Department of Pharmaceutical Chemistry, Indira Gandhi Institute of Pharmaceautical Sciences, I.R.C. Village,
Bhubaneswar,
Dist:Khurda, Odhisa -751015

Abstract:
Two methods are described for the simultaneous determination of Paracetamol and Chlorzoxazone in binary mixture. The first method was based on UV-spectrophotometric determination of two drugs, using simultaneous equation method. It involves absorbance measurement at 282.5 nm (λmax of Chlorzoxazone) and 248.0 nm (λmax of Paracetamol) in methanol; linearity was obtained in the range of 5 – 25 μg.mL-1 for both the drugs. The second method was based on HPLC separation of the two drugs in reverse phase mode using Promosil C18 column. Linearity was obtained in the concentration range of 100-500 μg.mL-1 for Paracetamol and 50-250 for  the Chlorzoxazone. Both these methods have been successively applied to pharmaceutical formulation and were validated according to ICH guidelines.

The Central Council for Research in Ayurvedic Sciences (CCRAS) is an autonomous body under the Department of Ayurveda, Yoga & Naturopathy, Unani, Siddha & Homoeopathy (AYUSH), Ministry of Health & Family Welfare, Government of India. The Council is an apex body in India for formulation, development and promotion of research in Ayurvedic system of medicine. The Council carries out its activities and functions through its network of 31 Institutions located all over India.

The Ministry of Health & Family Welfare, Government of India is setting up these six Autonomous Institutions of National Importance. For Faculty Positions/ Senior Residency applications are invited from Indian Nationals and Persons of Indian Origin holding OCI Status. Regular, Deputation, contractual appointments are open.

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About Authors:
Debayan Dey*, G.D Pattnaik, Bijay kumar Sahoo
Dept.of Pharmaceutics
College of Pharmaceutical Sciences,
Puri, Orissa

INTRODUCTION
Oral administration is the most convenient and preferred means of any drug delivery to the systematic circulation. Oral controlled release drug delivery have recently been of increasing interest in pharmaceutical field to achieve improved therapeutic advantages, such as ease of dosing administration, patient compliance and flexibility in formulation. Drugs that are easily absorbed from gastrointestinal tract (GIT) and have short half-lives are eliminated quickly from the systemic circulation. Frequent dosing of these drugs is required to achieve suitable therapeutic activity.

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