Uttarakhand

Recruitmet for SR.OFFICER/EXECUTIVE/TECHNICIAN-Production, Quality Control, Engineering at Sun Pharma/ Walk In

Sun Pharma is the fifth largest speciality generic pharmaceutical company In the world. We provide high-quality, affordable medicines trusted by healthcare professionals and patients in over 150 countries. It is also India's largest, most trusted and most valuable pharmaceuticals company by market capitalisation. Our leadership is approachable, encourages transparency & strong work ethics to ensure that people get the best opportunities to learn & grow. We encourage our employees to challenge themselves for highest level of performance through greater bandwidth of work responsibilities and growth opportunities. To keep pace with our growth plans, we require for our Formulation manufacturing plants at MohaliI Paonta Sahib/ Sikkim.

Post:- SR.OFFICER/EXECUTIVE/TECHNICIAN

Opportunity in Drug testing laboratory & production at Indian Medicines Pharmaceutical Corporation Limited - Govt Job

The Company, a ‘MINI RATNA’, ISO 9001-2008 and GMP Certified Central PSU, requires bright and dynamic professionals for the various departments of the Company on the basis of purely temporary arrangement for one year

Career as Pharmacist/ Asst.Pharmacist, Pharmacy Assistant, Centre In Charge for AMRIT Pharmacy Outlet at AIIMS

HLL Lifecare Limited, a Mini Ratna Central Public Sector Enterprise under the Ministry of Health & Family Welfare, Govt. of India is a global provider of high quality healthcare products & services. With state-of-the-art manufacturing facilities spanning across India, HLL is diversifying into vaccine manufacturing, lifecare services, sanitary napkins besides engaging in procurement consultancy, healthcare infrastructure development and facility management.

Post: Pharmacist/ Asst.Pharmacist, Pharmacy Assistant, Centre In Charge

DEVELOPMENT AND IN-VITRO DRUG RELEASE PROFILE OF SUSTAINED RELEASE FLOATING GRANULES OF CINNARIZINE

{ DOWNLOAD AS PDF }

ABOUT AUTHOR
Aman Mittal
Smt. Tarawati Institute of Biomedical & Allied Science
Roorkee, Uttarakhand, India
amanmittal_27@yahoo.com

ABSTRACT
Floating drug delivery systems (FDDS) are the drug delivery systems having a bulk density lower than the gastric content and they remain buoyant in the stomach for a prolonged period of time, with the potential for continuous release of drug. Cinnarizine, a H1-receptor antagonist, used for the treatment for vestibular vertigo disorders and motion sickness was selected as the drug aspirant and Gelucire 43/01 was selected as a lipid carrier in different ratio (1:0.5, 1:1, 1:1.5) along with drug to be formulated as gastro retentive multiparticulate system. The formulation F1 to F9 were prepared and formulation F4 to F9 were evaluated for in-vitro drug release and formulation F5 was selected as optimized formulation that exhibited good floating ability and zero order drug release (93.56 %) at the end of 8 hrs. The in-vitro drug release study of the aged sample show phase conversion of Gelucire. The phase conversion also caused increase in drug release. In conclusion, hydrophobic lipid, Gelucire 43/01 can be considered as an effective carrier for design of a multiple unit floating drug delivery system of cinnarizine.

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