Uttar Pradesh

DEVELOPMENT OF GASTRORETENTIVE FORMULATION OF ALPRAZOLAM

About Authors:
Pavitra Solanki1, Satyaveer Singh Solanki2
1- Research Scholar, KIET school of Pharmacy, Ghaziabad.
2- Asstt. Professor, Nehru Mahavidhyalaya, Lalitpur, Uttar Pradesh
*pavitra.bpharma@gmail.com

Abstract
The goal in designing controlled floating delivery system to reduce the frequency of dosing and / or to increase effectiveness of drug by localization at the site of action, reducing the dose required or providing uniform drug delivery with high bioavailability of buoyant drugs and also reduce the severity and frequency of side effects by maintaining patient blood levels of the drug above the minimum effective level and below the minimum toxic level.
Oral route has been the commonly adopted and most convenient route for drug administration. Oral route of administration has been received more attention in the pharmaceutical field because of the more flexibility in the designing of dosage form than drug delivery, design for other routes.  For sustained drug delivery dosing interval can be extended either by manipulating the drug molecule to reduce the rate of elimination or by altering the release rate of a dosage form to retard the rate of absorption. Both these approaches decrease fluctuating in plasma level in case of multiple dosing extending the dosing interval without under or over dosing.

Wanted Professors / Associate Professors / Asstt. Professors at Shambhunath Institute of Pharmacy

Shambhunath Institute of Engineering and Technology was set up by the UTTHAN, a world renowned N.G.O. in 2004 with an objective of imparting quality education in Engineering and Technology. The  aim  of   the   College  has  been  to  maintain  a  liaison  with  the industries on one hand and the premier engineering institutions of the region like the IIIT Allahabad, MNNIT, Allahabad, IERT Allahabad, JK Institute of Applied Physics (University of Allahabad, Allahabad), etc.

Job in AKUMS Drugs & Pharma | Require Trainee / Assistant Officer / Officer - QC, Manager QA, Research Scientist-AR&D, Executive in DRA, IPR, packaging development

AKUMS DRUGS & PHARMACEUTICALS LTD is one of the most innovative, productive and research based pioneer organization of India having its registered office at Delhi and various plants in Haridwar, Uttrakhand giving employment to more than 2000

Galgotias University invites PROFESSORS, ASSOCIATE PROFESSORS, ASSISTANT PROFESSORS in School of Medical & Allied Sciences

Galgotias University is led by a distinguished faculty having unparallel reputation in their respective fields in education who have come from all over India and the world to this university to make the students excel and develop them into successful individuals.

AN OVERVIEW ON PRECLINICAL EVALUATION TECHNIQUES OF NOOTROPIC AGENTS

ABOUT AUTHORS:
Renu Singh*, Saumya Das, Sanjita Das
Institute of Pharmaceutical Technology, NIET,
Greater Noida, U.P., 201306.

*renusingh2910@gmail.com

ABSTRACT
Cognitive deficits have long been recognized as severe and consistent neurological disorders associated with numerous psychiatric and neurodegenerative states such as Alzheimer’s disease. Dementia is one of the age-related mental problems, and a characteristic symptom of Alzheimer’s disease. Alzheimer’s disease (AD) is a progressive neurodegerative disorder which affects older individuals and may progress to a totally vegetative state. Atrophy of cortical and sub-cortical areas is associated with deposition of β-amyloid protein in the form of senile plaques and formation of neurofibrillary tangles. There is marked cholinergic deficiency in the brain, though other neurotransmitter systems are also affected. Various measures to augement cholinergic transmitter in the brain have been tried. The relatively cerebroselective anti-ChEs have been approved for clinical use. Nootropic agents are clinically used in situations where there is organic disorder in learning abilities and for improving memory, mood and behavior, but the resulting side-effects associated with these agents have made their utility limited. Many experimental models are currently available for the evaluation of agents that affect learning and memory processes. In-vitro methods inhibition of acetylcholinesterase activity is measured by determining IC50 with the help of Log probit analysis. In ex-vivo cholinesterase inhibition method the dose response relationship determined for drugs such as physostigmine and tacrine Agents which are H3 receptor agonist are evaluated for [3H] Ach release activity in rat using rat brain slices. The binding affinity of potential nicotinic cholinergic agonist in brain using agonist ligand is determined by [3H]-N- methyl carbamylcholine binding nicotinic cholinergic receptors in rat frontal cortex. In In-vivo methods the inhibitory passive avoidance the test are carried on animals to test the learning and memory capacity of animal by suppressing a particular behavior. It includes step down, step through, two compartment test, up-hill avoidance, scopolamine induced test, and ischemia induced amnesia, memory impairments in basal forebrain. In active avoidance conditioned stimulus is given to the animal, which gives noxious stimulus as a result. It includes runway avoidance, shuttle box avoidance, jumping avoidance. In discrimination learning animals have no choice between the conditioned stimuli. Studies on aged monkeys provides additional advantage for neurobehavioral animal model of aging in that many of behavioral processes thought to be affected by aging.

Fresher M.Pharm, M.Sc, B.Pharm, B.Sc invited for Marketing Executives, Marketing Managers, Formulation Development in Olefia Biopharma - more than 100 vacancies

Olefia Biopharma Limited, We would like to introduce ourselves as one of the most rapidly emerging FMCG Company in various fields of Pharmaceutical, Cosmetics, Ayurvedics / herbals and biotech.
Olefia Biopharma Limited is utilising MHRA and WHO-GMP Approved manufacturing unit to manufacture various Tablets, Capsule, Syrups, Suspensions and other formulations for its various division viz. Pharmaceutical and Cosmetic i.e. FMCG and exporting to various countries across the Globe.

Mutiple vacancies in BBDU | Require Faculty - Professor, Associate Professor, Assistant Professor, Lecturer and Lab Staff

BBD University strive to educate students in a way that transforms them into leaders who can make a difference in the world. We aim to impart futuristic and high quality technical, management and medical education to the young and talented Indian and international students.

A SHORT REVIEW ON STOMACH SPECIFIC DRUG DELIVERY SYSTEM

About Authors:
Garima Gupta*, Amit Singh
Department of Pharmaceutics,
R.V. Northland Institute,
Greater Noida, G. B. Nagar, U.P.

*Garima189@gmail.com

Abstract:
Technological attempts have been made in the research and development of rate-controlled oral drug delivery systems to overcome physiological adversities, such as short gastric residence times (GRT) and unpredictable gastric emptying times (GET). Conventional oral dosage forms pose low bioavailability problems due to their rapid gastric transition from stomach, especially in case of drugs which are less soluble at alkaline pH of intestine. Similarly, drugs which produce their local action in stomach get rapidly emptied and do not get enough residence time in stomach. So, frequency of dose administration in such cases is increased. To avoid this problem, various efforts have been made to prolong the retention time of drug delivery system. In this review, we will discuss about the various approaches to produce gastro retention of drug delivery system, with current & recent developments of Stomach Specific floating drug delivery system.

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