A study by Graham Knott at EPFL has successfully used an innovative method, called 'cryofixation', to prevent brain shrinkage during the preparation for electron microscopy. To study the fine structure of the brain, including its connections between neurons, the synapses, scientists must use electron microscopes. However, the tissue must first be fixed to prepare it for this high magnification imaging method. This process causes the brain to shrink; as a result, microscope images can be distorted, e.g. showing neurons to be much closer than they actually are. Scientists have now solved the problem by using a technique that rapidly freezes the brain, preserving its true structure.