Solan

NUTRITIONAL VALUE OF DRY FRUITS AND THEIR VITAL SIGNIFICANCE - A REVIEW

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About Authors:
Pooja Dhiman, Kanika Soni, Sandeep Singh
Chitkara University,
Kalujhanda, Barotiwala,
Solan, Himachal Pradesh, INDIA
pooja.dhiman@chitkarauniversity.edu.in

ABSTRACT:
As a snack, dried fruit is drastically superior to junk foods, such as potato chips, pretzels, candy bars, and other unhealthy indulgences people reach for when they are hungry between meals. Dry fruits are small but are extremely rich sources of minerals and proteins. Every diet specialist always recommends a handful of dry fruits in our diet in order to keep us healthy and fit. There are just umpteen varieties in dry fruits such as raisins, cashew nuts, almonds, pistachios, walnuts, dates, plums and the list goes on.

MEDICINAL VALUE OF CAROM SEEDS – AN OVERVIEW

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The carom seeds botanical name Trachy spermumammi belong to the family of Apiaceae (Umbelliferae), of the genus; Trachyspermum. The Umbellifers are the members of carrot or parsley family, which includes many herbs and spices such as dill, fennel, anise seed, and caraway, is an annual herbal plant growing up to 3 feet in height.  Some of the common names for the seeds are Bishop’s Weed, Ajowan, carom, Caraway and thymol seeds.etc. Carom seeds are ovoid, light brown colour seeds. They have narrow green leaves and small delicate flowers. The fruits pods of these plants are often called seeds for their seed-like appearance. The Carom plants are believed to have originated from Egypt in Middle East. They are widely grown in India, Afghanistan and Iran. These plants can be grown easily from the seeds.Well drained loam soil with a pH between 6.5 and 8.2 is ideal for their cultivation. They grow well in cold temperatures ranging from 15 °C to 25 °C. The plants can grow both in direct and partial sunlight. Relative humidity between 65% and 70 % are required for their proper growth. The umbels are harvested after they are properly matured. Harvesting is done during the later parts of winter or earlier in spring. These seeds are used as a spice in cooking. The umbels of the plant mature and produce the seeds. Ajwain is renowned for their medicinal value. Ajwain seeds are strongly pungent and aromatic in its taste.

AN INSIGHT TO IN-SITU GEL FORMING STOMACH SPECIFIC DRUG DELIVERY SYSTEM

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ABOUT AUTHORS:
Deepak Kumar*, Palak Kapoor
Shoolini University,
Solan, Himachal Pradesh
deepakkaushik354@gmail.com

ABSTRACT:
The oral delivery of drugs having narrow absorption window in the gastro-intestinal tract is limited by poor bioavailability with conventional dosage forms due to incomplete drug release and short residence time at the time of absorption. To provide controlled delivery of drugs novel drug delivery systems have been developed. Different systems have been developed to increase the gastric residence time viz. floating system, mucoadhesive, high density, expandable. Among all oral dosage forms, liquid orals are more prone to low bioavailability due to fast transit time from stomach to duodenum. Sustained/Controlled delivery can be achieved by decrease in the transit time of the dosage form. This can be augmented by an approach of liquid in-situ gelling system. These in-situ formulations are the drug delivery systems that are in sol form before administration in the body, but when administered, undergo gelation, in-situ, to form a gel. Formation of gel depends on various factors viz. temperature modulation, pH change, presence of ions, ultra-violet irradiation, from which drug releases in a sustained and controlled fashion. Different polymers which can be used for formation of in-situ gel include gellan gum, alginic acid, xyloglucan, pectin, chitosan, poly-caprolactone, poly-lactic acid, poly-lactic-co-glycolide. This article presents a detailed review of introduction, approaches to achieve in situ gelling system, polymers used, evaluation parameters, advantages of in situ gelling system.

FORMULATION DEVELOPMENT AND IN-VITRO EVALUATION OF HYDROPHILLIC MATRIX BASED SALBUTAMOL SULPHATE TABLETS

ABOUT AUTHORS:
Pankaj Verma*, Tapaswi Rani Dash
M.Pharm, Pharmaceutical Technology
Asst. Prof., Pharmaceutics, School of Pharmacy and Emerging Sciences, Solan
*pankaj.pharma23@gmail.com

ABSTRACT
Salbutamol sulphate (SS), a directly acting sympathomimetic drug, is a good candidate for controlled release formulations due to its short half-life of 1.6-3 h but it is quite challenging because of its high water solubility. The purpose of this research work is to design oral controlled-release matrix tablets of Salbutamol Sulphate using hydrophilic polymers, and thus increase patient compliance by reducing its frequency of administration. Salbutamol Sulphate matrix tablets are to be designed by direct compression method using HPMC K4M CR, HPMC K100M CR and Xanthan gum as various release retarding agents. These release rate retardents are used to control the drug release up to 24 h for administration as once daily dose. The compatibility of the drug with the various excipients is to be studied using FT-IR and DSC. The effects of polymer concentration, polymer viscosity and binary mixtures of some polymers on the in-vitro drug release are to be studied. Salbutamol Sulphate matrix tablets are used for the treatment of respiratory disorders like choronic asthma,bronchitis, bronchiolitis, chronic obstructive pulmonary disease (COPD) etc. . It possibly stimulates β-2 reseptors in lungs resulting in relaxation of smooth muscles by its β-2 agonist action.

ALZHEIMER’S DISEASE Vs. DEMENTIA- A REVIEW

About Authors:
Ms. Kanika Soni, Ms. Pooja Dhiman*, Mr. Sandeep Singh
Chitkara University, Kalujhanda, Atal Shiksha Kunj,
Barotiwala, Solan [H.P], INDIA
*pooja.dhiman@chitkarauniversity.edu.in

Abstract-
Alzheimer's disease, the commonest cause of dementia in older people which causes immense distress to patients, their caregivers and families. The aetiology of Alzheimer's disease remains unknown, and no treatments reverse or stabilise the disease. Current management focuses on establishing an accurate clinical diagnosis, ensuring appropriate services are provided, supporting caregivers and treating associated non-cognitive problems because Alzheimer’s disease is the main cause of dementia. Dementia affects memory, thinking, language, judgment, behaviour, and a person’s ability to perform normal daily activities. Dementia is a word that describes symptoms of the gradual deterioration of mental functioning that cannot be explained by normal aging. Dementia occurs primarily in people who are over the age of 65, or in those with an injury or disease that affects brain function. While dementia is most commonly seen in the elderly, it is not a normal consequence of the aging process.

A REVIEW OF MEDICINAL PLANTS WITH HEPATOPROTECTIVE ACTIVITY

ABOUT AUTHORS:
Shristi Badhani*, Shivani Sharma, Amrita Kainth, Bharat Parashar
Department of Pharmacy,
Manav Bharti University, Solan, H.P.
*shristibadhani0104@gmail.com

ABSTRACT:
Hepatic diseases are a major worldwide health problem, with frequently found in developing countries. They are mainly caused by uses of high doses of chemicals and some drugs. There is no effective drug available that stimulates liver function, offer protection to the liver from damage or help to regenerate hepatic cells. Therefore there is urgent need, for effective drugs to replace/add those in current use. Medicinal herbs are significant source of pharmaceutical drugs. Latest trends have shown increasing demand of phytoconstituents from some medicinal herbs and those medicinal herbs have proven hepatotprotective potential.A number of herbal preparations are available in the market. The present review is aimed at compiling data on promising phytochemicals from medicinal plants that have been tested in hepatotoxicity models using modern scientific system. In this century clinicalresearch has confirmed the efficacy of  some herbs in the treatment of liver related disease. Hence, this review article contributes to the knowledge of reported indigenous plants, which are prevalent for prevention and treatment ofliver disorders.

Work as PROFESSIONAL SERVICE REPRESENTATIVES, AREA MANAGER in Karnataka Antibiotics & Pharmaceuticals Ltd.

Karnataka Antibiotics & Pharmaceuticals Ltd., (KAPL) Bangalore is a Government Enterprise.  From a modest beginning in 1984, KAPL has grown from strength to strength in the areas of manufacturing and marketing of various life saving and essential drugs. With an ISO accredition from KPMG, Netherlands, KAPL is recognised for its total commitment to quality and services in domestic and international markets. On profit from inception, KAPL facilities are approved by many international clients.

THERAPEUTIC POTENTIAL OF VENOMOUS PEPTIDE IN VARIOUS DISEASES

ABOUT AUTHORS:
1*Anjali Choba, 2Shikha Attri
1M.Pharma in pharmacology from shoolini university solan, himachal pradesh
2M.Pharm in pharmaceutical chemistry from lachoo memorial college of science and technology, jodhpur
*anji5057@yahoo.in

ABSTRACT
Venomous creatures have a sophisticated mechanism for prey capture which includes a vast array of biologically-active compounds, such as enzymes, proteins, peptides and small molecular weight compounds. The venom peptides are directed against a wide variety of pharmacological targets, making them an invaluable source of ligands for studying the properties of these targets in different experimental paradigms. Much knowledge has been gained in terms of how poisons and venoms and their composite toxins give rise to the syndromes associated with envenoming and poisoning and in some isolated cases there have been a few such agents promoted for therapeutic use. A number of these peptides have been used for the treatment of pain, diabetes, multiple sclerosis and cardiovascular diseases.

Wanted M.Pharm, M.Tech, M.Sc for the post of Research Scholars in JUIT

Applications are invited for the positions of Research Scholars in the Department of Biotechnology, Bioinformatics and Pharmaceutical Sciences. The research scholars will get an opportunity to work in the following areas under externally funded R&D projects worth Rs. 15.0 crores, including prestigious ones such as a DBT programme support under Centers of Excellence & Innovation in Biotechnology, DBT RGYI, DST-FIST, etc. in addition to DRDO, MoEF, ICMR funded.

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