ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY OF METHANOLIC EXTRACT OF WHOLE PLANT OF SIDA ACUTA (LINN.F.ND)
About Authors:
*Virendra Sharma, Pooja Sinoriya, Sunil Sharma
Lakshmi Narain Academy of Pharmacy, Gwalior
Kumud23@indiatimes.com
Abstract
To evaluate the anti-inflammatory and analgesic activity of methanolic extract of whole plant of Sida acuta in experimental animal models. Methanolic extract of whole plant of Sida acuta (MESA) (100, 200 and 400 mg/kg p.o.) was studied for its anti-inflammatory activity using Carrageenan induced rat paw edema animal model and analgesic activity at the same dose level using acetic acid induced writhing test and Hot plate analgesia in mice. The methanolic extract of whole plant of Sida acuta (MESA) (100, 200 and 400 mg/kg p.o.). The PI with indomethacin and Sida acuta in carrageenan induced paw edema at the dose level 400 mg/kg were 60% and 52.5% at the end of 5 hr. In the acetic acid induced writhing test, the extract at the dose level 400 mg/kg showed 83.78% inhibition of writhing. In radiant heat tail- flick method the extract at the dose 400 mg/kg showed reaction time 4.902 ± 0.545 (p<0.001). The methanolic extract possesses anti-inflammatory and analgesic activity.